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Study looks at denosumab in preventing bone loss caused by aromatase inhibitors

Denosumab is a new drug being studied to prevent fractures in breast cancer patients receiving hormonal therapy.

17 Dec 2007

Controlling lupus - new drug targets found

Investigators at Hospital for Special Surgery have identified two new targets for drugs aimed at controlling lupus.

17 Dec 2007

Dynamic connectivity rewires neuronal circuits on the fly to sharpen senses

Researchers from the Center for the Neural Basis of Cognition (CNBC), a joint project of Carnegie Mellon University and the University of Pittsburgh, have for the first time described a mechanism called "dynamic connectivity," in which neuronal circuits are rewired “on the fly” allowing stimuli to be more keenly sensed.

17 Dec 2007

Deference or respect? status management practices among prison inmates

In community settings, there's always at least one person or perhaps a group of individuals who are most highly respected. Prison systems are no different; one's social status results from interpersonal dynamics.

17 Dec 2007

Men unaware of their cancer risk when female relatives test positive for BRCA mutation

Men whose mothers, sisters or daughters test positive for a cancer-causing gene mutation also have an increased risk of developing the disease but are unaware of that risk.

17 Dec 2007

Rituximab used to treat skin disorders

A new review article from the journal Dermatologic Therapy reveals that rituximab, a drug used to treat lymphoma, is now becoming used by dermatologists to treat various dangerous skin diseases.

17 Dec 2007

Genetic cause of Kawasaki disease

Researchers from Japan's RIKEN SNP Research Center, collaborating with a team at the University of California, San Diego (UCSD), have discovered a new genetic variation that affects a child's risk of getting Kawasaki disease (KD), an illness characterized by acute inflammation of the arteries throughout the body.

17 Dec 2007

Complex path to cell death shown by identification of new genes

Can a tiny winged insect's salivary glands really tell us about processes relevant to human disease? Yes, according to a new study by researchers at the University of Massachusetts Medical School (UMMS), who gained new insights into autophagy - a cellular degradation process associated with a form of programmed cell death - by studying the salivary gland cells of the fruit fly.

17 Dec 2007

How molecular muscles help cells divide

Time-lapse videos and computer simulations provide the first concrete molecular explanation of how a cell flexes tiny muscle-like structures to pinch itself into two daughter cells at the end of each cell division, according to a report in Science Express.

17 Dec 2007

Highly promising Alzheimer's and Parkinson's research

The TI Pharma project is a large-scale study into the brain material of Alzheimer's and Parkinson's patients, who gave permission to the Netherlands Brain Bank for their tissue to be used for scientific research.

17 Dec 2007

Herceptin helps women with multiple chromosomes containing HER2 gene

The targeted therapy Herceptin helps women with HER2+ type of breast cancer independent of whether patients have extra copies of chromosome 17, home to the HER2 gene which produces the HER2 protein that fuels cancer growth.

17 Dec 2007

Exposure to traffic pollution can lead to chronic effects in the respiratory health of children with asthma

Exposure to traffic pollution may increase respiratory problems and reduce lung volumes in children with asthma, according to researchers who studied the effects of road and traffic density on children's lung function and respiratory symptoms in the border town of Ciudad Juarez in Mexico.

17 Dec 2007

Children require more health care when their mothers are victims of domestic violence

Children whose mothers have a history of abuse by intimate partners have higher health care needs than children whose mothers have no history of abuse, according to a study conducted at Group Health, a Seattle-based health plan.

17 Dec 2007

For babies with specific complex heart defects, death risk is far lower at most experienced hospitals

Each year, thousands of babies are born with severe heart defects that must be operated on within days or weeks of their birth.

17 Dec 2007

Evolution with a restricted number of genes

The development of higher forms of life would appear to have been influenced by RNA polymerase II.

17 Dec 2007

Tumors less than 1 centimeter in size can be aggressive and may require maximum therapy

Breast tumors that are 1 centimeter in size or smaller - no more than 0.4 inch in length - can still be very aggressive and may require more intensive therapy than is routinely offered today, say researchers at Mayo Clinic in Jacksonville, Fla.

17 Dec 2007

Avastin shows promise for brain cancer

A clinical study conducted at Henry Ford Hospital on the use of a drug to extend the survival of patients with the most common and aggressive type of brain cancer, has yielded results that were significantly better than expected.

17 Dec 2007

Targeted therapy and chemotherapy shrinks breast cancer metastases in brain

A combination of a "targeted" therapy and chemotherapy shrank metastatic brain tumors by at least 50 percent in one-fifth of patients with aggressive HER2-positive breast cancer, according to data presented by Dana-Farber Cancer Institute investigators at the San Antonio Breast Cancer Symposium.

17 Dec 2007

Cholesterol affects your hearing

Levels of cholesterol in the membranes of hair cells in the inner ear can affect your hearing, said a consortium of researchers from Baylor College of Medicine, Rice University and Purdue University in a report in the print edition of The Journal of Biological Chemistry.

17 Dec 2007