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Review of six large-scale clinical trials of aliskiren

Hypertension is a serious condition affecting millions.Currently there are seven classes of drugs used to reduce blood pressure. Aliskiren (Tekturna , Rasilez) is the first of a new class of orally active antihypertensive drugs that works by inhibiting renin.

10 May 2007

Researchers watch repair proteins arrive around DNA breaks

Investigators at St. Jude Children's Research Hospital had a molecule's eye view of the human cell's DNA repair kit as it assembled on a double-strand break to link together the broken ends.

10 May 2007

Discovery of cellular processes which regulate heart's energy supply

The heart needs a steady supply of energy to function properly. MUHC researcher Dr. Vincent Gigure's and his colleagues recently identified several genetic programs which work together to ensure this energy is available.

10 May 2007

Heart failure patients should be thoroughly evaluated for the presence of diabetes

New research from UAB (University of Alabama at Birmingham) shows that the effect of diabetes on the severity of illness and risk of death for patients with heart failure is much worse in women than men.

10 May 2007

Cornell University establishes Center for Reproductive Genomics

Cornell University has established the Center for Reproductive Genomics, which will combine basic research in reproductive sciences on Cornell's Ithaca campus with one of the country's leading fertility clinics at Weill Cornell Medical College (WCMC) in New York City.

10 May 2007

Patients around the world face stark inequalities in access to cancer treatment

The report's authors urge decision makers in every country to take action and ensure that everyone has equal access to new cancer drugs when they are needed, wherever they live.

10 May 2007

Coarse particulate matter in outdoor air raises bad cholesterol

Breathing air containing coarse particulate matter such as road or construction dust may cause heart problems for asthma sufferers and other vulnerable populations, according to a new study led by the University of North Carolina at Chapel Hill School of Public Health.

10 May 2007

When is food "done" enough to prevent food poisoning?

Food scientists have found that relying only on internal color to check if food is cooked properly isn't adequate. A beef patty may be brown throughout before it reaches 160 degrees Fahrenheit, the recommended minimum safe temperature. And a safely cooked hamburger may still appear pink on the inside.

10 May 2007

Structural variation in the human genome

A major new effort to uncover the medium- and large-scale genetic differences between humans may soon reveal DNA sequences that contribute to a wide range of diseases, according to a paper by Howard Hughes Medical Institute investigator Evan Eichler and 17 colleagues published in the May 10, 2007, Nature.

10 May 2007

Bristol-Myers Squibb collaborates with Isis Pharmaceuticals

Bristol-Myers Squibb Company and Isis Pharmaceuticals have announced a collaboration to discover, develop and commercialize novel antisense drugs targeting proprotein convertase subtilisin kexin 9 (PCSK9) for the prevention and treatment of cardiovascular disease.

10 May 2007

Caring for the sick now a public health priority for developing countries

Palliative care is commonly used in developed countries to improve the quality of life of patients with life-threatening illnesses, through strategies aimed mainly at pain relief.

10 May 2007

Recent developments for drug-eluting stents

Drug-eluting stents -- small metal tubes used to prop open clogged arteries -- have been garnering headlines.

10 May 2007

America's Health Insurance Plans statement on health care

At a roundtable of key business, labor, government, community, and health care leaders from across the nation sponsored by the Department of Health and Human Services (HHS), Karen Ignagni, President and CEO of America's Health Insurance Plans (AHIP), issued the following statement on progress in providing the highest value health care to patients:

10 May 2007

Project unites U.S., Singapore and Indonesia in the fight against bird flu

Indonesia the nation worst hit by bird flu is clearly struggling to cope with the deadly virus but has now joined with close neighbour Singapore to control the spread of the H5N1 virus.

9 May 2007

Experts explain China's mystery pig disease

According to media reports a mysterious disease has killed thousands of pigs in China's southern Guangdong province.

9 May 2007

Bipolar all too often misdiagnosed

According to researchers from the National Institute of Mental Health (NIMH) there are twice as many Americans with bipolar disorder as previously thought, and many are untreated.

9 May 2007

Bipolar disorder - the clue may be in the genes

The first scan of the entire human genetic code has revealed that developing bipolar disorder may to some extent depend on the combined effects of variations in many different genes in the brain, none of which is powerful enough to cause the disease by itself.

9 May 2007