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Wrapping version of Gleevec fights drug-resistant cancer

A new study highlighted on the cover of this week's issue of Cancer Research finds that the anti-cancer drug Gleevec? is far more effective against a drug-resistant strain of cancer when the drug wraps the target with a molecular bandage that seals out water from a critical area.

2 May 2007

U.S. Supreme Court decision boosts stem cell patent challenge

A U.S. Supreme Court decision in favor of KSR International Corp. on Monday strengthens challenges against overreaching human embryonic stem cell patents held by an affiliate of the University of Wisconsin, the Foundation for Taxpayer and Consumer Rights (FTCR) and the Public Patent Foundation (PUBPAT) said.

2 May 2007

New compounds show potential for cognitive disorders

UC Irvine researchers have identified a new class of compounds that could be used for drugs to treat cognitive disorders that accompany schizophrenia, Alzheimer's disease and ADHD, according to an article published today in the online version of the Proceedings of the National Academy of Sciences.

2 May 2007

Testosterone cream does not increase sexual drive in female cancer survivors

Increasing the testosterone levels of female cancer survivors using testosterone cream did not improve their libido more than a placebo, according to a randomized controlled clinical trial in the May 2 Journal of the National Cancer Institute.

2 May 2007

Levosimendan compared to dobutamine for decompensated heart failure

The drug levosimendan did not improve survival for patients with decompensated heart failure when compared with a more widely-used treatment for this condition, dobutamine, according to a study in the May 2 issue of JAMA.

2 May 2007

Unstable leukemia stem cells may predispose patients to drug resistance

The BCR-ABL gene in chronic myeloid leukemia stem cells has a tendency to quickly mutate, and this may help explain why patients are predisposed to resistance to drugs like imatinib that target that gene, according to a study in the May 2 Journal of the National Cancer Institute.

2 May 2007

Web-based disease management program improves outcomes for low-income black students

Low-income African-American high school students with asthma who participated in a specially-designed, web-based disease management program reported fewer days and nights with symptoms, fewer school days missed, fewer days of restricted activity, and less hospitalization for asthma during a 12-month follow-up period, as compared to non-participating asthmatic students.

2 May 2007

Why do some people get fat even when they eat relatively little?

What creates that irresistible urge for a bag of potato chips or a hunk of chocolate cake, as opposed to a nice crisp apple? Can food urges be irresistible?

2 May 2007

Doctors ill equipped to confront parent smoking

With the growing concerns of children's exposure to secondhand smoke, it has become more critical than ever to involve health care providers such as pediatricians in educating parents about the potential hazardous health consequences.

2 May 2007

Childhood-onset bipolar disorder is more common than believed

In bipolar disorder, also called manic-depressive disorder, a person experiences mood changes that fluctuate between periods of abnormally high energy and extreme depression.

2 May 2007

Culture can alter the brain's perceptive mechanisms

Researchers in Illinois and Singapore have found that the aging brain reflects cultural differences in the way that it processes visual information.

2 May 2007

Losing money may be intrinsically linked with fear and pain in the brain

In a Wellcome Trust study published in the Journal of Neuroscience, researchers have shown that during a gambling task, losing money activated an area of the brain involved in responding to fear and pain.

2 May 2007

Combination treatment cures mice of a very aggressive human breast tumor

A combination of three different drugs that block the HER-2 receptor, a critical cellular growth signal for some breast cancers, eradicated aggressive breast tumors in mice and could point the way toward developing better treatments inpatients, said researchers from the Breast Center at Baylor College of Medicine in a report that appears today in the Journal of the National Cancer Institute.

2 May 2007

CleveMed receives approval to market motor assessment system

Cleveland Medical Devices has received Food and Drug Administration (FDA) clearance to market Kinesia, a quantitative motor assessment system.

2 May 2007

New class of nontoxic cancer treatments

A new class of compounds developed by two University of Kentucky researchers shows promise as a nontoxic treatment of some cancers previously treated with toxic chemotherapy, the researchers report today.

2 May 2007

Top 10 diseases by cost

Bladder, prostate and other urinary tract diseases cost Americans nearly $11 billion a year, according to a new report from the National Institutes of Health.

2 May 2007

Chronic fatigue syndrome impairs sleep and homeostatic response

Chronic fatigue syndrome (CFS) has been associated with altered amounts of slow wave sleep, which could reflect reduced electroencephalograph (EEG) activity and impaired sleep regulation.

2 May 2007

A mobile medical care approach targeting underserved populations in post-hurricane Katrina Mississippi

They packed what they needed for a disaster - equipment for trauma treatment and IV fluids - and headed south to Mississippi.

2 May 2007

Gulf War veterans with health symptoms show differences in brain structures

Veterans of the first Gulf War who returned with multiple health symptom complaints show significant differences in brain structures from their fellow returnees without high numbers of health symptoms, according to research that will be presented at the American Academy of Neurology's 59th Annual Meeting in Boston, April 28 ,May 5, 2007.

2 May 2007

Allocation of deceased donor organs

While the field of transplantation is quite young, substantial advancements and success have led to the current imbalance between the supply of organs and the demand for them.

2 May 2007