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Second-generation dendrimer disintegrates upon command

Dendrimers, highly branched, spherical polymers, have demonstrated their utility as drug and imaging agent delivery vehicles for use in detecting and treating cancer, with several dendrimer-based agents nearing human clinical trials.

29 Jan 2007

Design of gold nanoparticles for magnetic resonance imaging

Molecular complexes containing the element gadolinium are proven agents for increasing the diagnostic utility of magnetic resonance imaging (MRI), but their use in detecting small tumors is limited by the relatively weak signal these agents produce.

29 Jan 2007

Polymer nanoparticles for immunotherapy from encapsulated tumor-associated antigens and whole tumor cells

Using a biodegradable nanoparticle as a means of delivering tumor cell debris and proteins to the immune system, investigators at Yale University have developed a promising new method for creating therapeutic anticancer vaccines.

29 Jan 2007

Healthcare Research and Development Institute reaches settlement with two State Attorneys General over alleged anticompetitive practices

The Florida-based Healthcare Research and Development Institute, a consulting group owned by about three dozen hospital executives, has agreed to no longer accept fees from companies that sell medications, medical devices and financial services to not-for-profit hospitals nationwide, according to a settlement reached on Wednesday with the Connecticut and Florida attorneys general, the New York Times reports.

29 Jan 2007

New drug to treat kidney failure during septic shock

Research from Melbourne's Howard Florey Institute and the Austin Hospital has resulted in a drug to treat kidney failure during septic shock, which will be trialled at the Austin Hospital from mid-2007.

29 Jan 2007

China should own up to past HIV/AIDS mistakes

Although China in recent years "has made bold strides in its response to HIV/AIDS," the number of new HIV/AIDS cases will continue to increase unless the country "owns up to past mistakes, encourages and supports civil society involvement, and proactively deals with the serious challenges of stigma and misinformation".

29 Jan 2007

HIV/AIDS advocates call on Zimbabwe to address broad health care issues

Although some HIV/AIDS advocates in Zimbabwe are welcoming a recent pledge from the Zimbabwean government to provide increased access to antiretroviral drugs by the end of this year, they also are stressing the need to address a broader crisis in the country's health care system, VOA News reports.

29 Jan 2007

Greater Boston Interfaith Organization urges delay in penalties against uninsured

The Greater Boston Interfaith Organization on Wednesday asked state officials to delay for one year a provision of the Massachusetts health insurance law that will penalize residents who do not obtain insurance by July 1, the Boston Globe reports.

29 Jan 2007

Sequenom and Lenetix to develop Rhesus D prenatal diagnostic

Sequenom, Inc. and Lenetix Medical Screening Laboratory, Inc., a provider of rapid genetic screening and diagnostic testing for clinicians worldwide, today announced that they have entered into a collaboration and license agreement to develop and commercialize a proprietary non-invasive prenatal Rhesus D (RhD) incompatibility test based on Sequenom patent rights and RT PCR methodology.

29 Jan 2007

FoxOs shown to be potential new targets for cancer drugs

In an elegant, multiple-gene knockout experiment, a team of Boston scientists has discovered that a trio of molecules, called FoxOs, are fundamentally critical in preventing some cancers, maintaining blood vessel stability, and in keeping blood-forming stem cells healthy.

29 Jan 2007

Potential protection against failed back surgery syndrome

Texas researchers believe that they have discovered how to prevent many cases of the most common problem encountered by patients undergoing spine surgery: failed back surgery syndrome (FBSS).

29 Jan 2007

Nicotine addiction depends on a healthy insula

Smokers with a damaged insula - a region in the brain linked to emotion and feelings - quit smoking easily and immediately, according to a study in the Jan. 26 issue of the journal Science.

29 Jan 2007

Antibiotic doses could be reduced by up to 50 times using new approach

Steven Hagens, previously at the University of Vienna, told Chemistry & Industry, the magazine of the SCI, that certain bacteriophages, a type of virus that infects bacteria, can boost the effectiveness of antibiotics gentamicin, gramacidin or tetracycline.

29 Jan 2007

SH2B1 protein plays a key role in controlling body weight, response to insulin and leptin

A single protein in brain cells may act as a linchpin in the body's weight-regulating system, playing a key role in the flurry of signals that govern fat storage, sugar use, energy balance and weight, University of Michigan Medical School researchers report.

29 Jan 2007

Poverty, gender inequality contributing to spread of HIV in Caribbean

Poverty, gender inequality and discrimination are hampering efforts to curb the spread of HIV in the Caribbean, speakers at the Caribbean Summit on HIV/AIDS in St. Croix, U.S. Virgin Islands, said on Sunday, the Caribbean Net News reports.

28 Jan 2007

Guyanese Health Ministry to provide $450,000 for HIV/AIDS programs

The Guyanese Ministry of Health on Tuesday announced it will provide $450,000 to 16 nongovernmental organizations to conduct HIV/AIDS programs nationwide, the Stabroek News reports.

28 Jan 2007

Panel recommends FDA to not create specific effectiveness standard for oral contraceptive approvals

A panel of gynecologists, researchers and other medical experts on Wednesday at the end of a two-day meeting convened by FDA recommended the agency not set a specific standard of effectiveness for approval of oral contraceptives, the AP/Minneapolis Star Tribune reports.

28 Jan 2007

HIV prevention and education initiatives are not reaching girls in Africa

According to Bruce, young African girls often have low school attendance and few friends, making them hard to reach. Impoverished girls are more likely to engage in commercial sex work, which increases their risk of contracting HIV, Bruce said.

28 Jan 2007

Violence against women fueling spread of HIV worldwide

Violence against women worldwide is fueling the spread of HIV in the population, and unwillingness among some governments to acknowledge the issue will continue to undermine prevention and education efforts, advocates said this week at the World Social Forum in Nairobi, Kenya, Inter Press Service reports.

28 Jan 2007

Bush promotes health care proposals

Initiatives that encourage U.S. residents to purchase health insurance through the private insurance market are the best way to expand coverage and reduce health care costs, President Bush said Thursday while visiting a Missouri hospital to promote the health care proposals he outlined earlier this week in his State of the Union address, the Washington Post reports

28 Jan 2007