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SERPINE2 identified as novel candidate gene for COPD susceptibility

Using a combination of genetic linkage, microarray gene expression and genetic association studies, a group of Brigham and Women’s Hospital/ Harvard Medical School researchers have identified a serine protease inhibitor clade E, member 2, or SERPINE2, “as a novel candidate susceptibility gene for COPD,” according to Sorachai Srisuma

3 Apr 2005

Moderate aerobic exercise improves cardiovascular and nervous system function in HIV+ subjects

Researchers from Teachers College, Columbia University, and Coler Goldwater Specialty Hospital and Nursing Facility report that moderate aerobic exercise for 10 weeks, three times a week for 45 minutes each session significantly improved function of the nervous system and circulation in those with HIV disease.

3 Apr 2005

Study of Anoxia could yield better anesthetics, stroke/heart attack recovery

For a human, mere minutes without oxygen (called anoxia) resulting from cardiac arrest, cerebral stroke or being trapped under water can lead to profound tissue damage and even death. However a Western painted turtle can survive anoxia for months without apparent tissue damage. Why, and how?

3 Apr 2005

Could NAADP/cholecystokinin-combo attack fat from inside and out?

One traditional approach to pharmaceutical design uses so-called “first messengers” – hormones, other natural facilitators or synthetic products – to initiate various cellular cascades for the desired physiological effect. To date, despite concerted efforts at all levels of research, this approach has failed to develop a truly successful obesity drug to address this major global health problem.

3 Apr 2005

Statins, other cholesterol-depleting agents, may disrupt hypertension from developing

Cholesterol-lowering agents, such as the widely-prescribed statin drugs, and cholesterol-blocking agents may prove to be “novel therapeutic agents to modify cellular calcium that contributes to the development of pulmonary hypertension,” according Hemal H. Patel who lead a multidisciplinary team of researchers at the University of California, San Diego (UCSD).

3 Apr 2005

Cranberry juice may help protect against heart disease

Protection against a wide variety of diseases is among the many benefits of a diet high in whole fruits and vegetables. Cranberries over the years have been identified with preventing or ameliorating urinary tract infections and playing a positive role gum disease, ulcers and even cancer.

3 Apr 2005

Children with autism have a severely abnormal metabolic profile

Chronic biochemical imbalance is often a primary factor in the development of many complex diseases but a possible metabolic basis for autism has not been well explored. Now Arkansas Children's Hospital Research Institute researchers report for the first time that children with autism have a severely abnormal metabolic profile indicating increased vulnerability to oxidative stress.

3 Apr 2005

Asthma patients' immune systems respond differently with allergies

Researchers from the University of Chihuahua in Mexico report that immune systems of patients with asthma responded differently to a common laboratory challenge, depending on whether their white blood cells had been obtained during a time when they were suffering from common season allergic rhinitis or when they were free of such allergic symptoms.

3 Apr 2005

Simvastatin linked to protection against endothelial dysfunction in diabetic rats

Almost two years ago, the diabetes arm of the Heart Protection Study, the largest-ever study using a cholesterol-lowering medication, found that diabetics who took a daily dose of the statin drug simvastatin over five years reduced the risk of a first nonlethal heart attack by 37 percent and risk of a first nonfatal or fatal stroke by 24 percent, regardless of their cholesterol or glucose levels.

3 Apr 2005

Garlic protects against severe chronic pulmonary hypertension

Small daily doses of allicin, the active metabolic in garlic, proved effective in preventing a severe form of pulmonary hypertension in rats

3 Apr 2005

Community MRSA is re-emergence of 1950's pandemic

This "re-equipping and re-emergence" of a clone that caused a pandemic 40-50 years ago could mean that community acquired MRSA will spread faster and be more widespread than previously expected, warns an international team of researchers who have been studying the bacteria.

3 Apr 2005

Sea floor may yield disease cures

On Monday, the Harbor Branch drug discovery group will begin a 2-week expedition to explore the Straits of Florida in search of organisms that produce chemicals with the potential to cure diseases such as cancer and Alzheimer's.

3 Apr 2005

Political point-scoring over policies to control MRSA confuses real issue

Political point-scoring over policies to control MRSA (meticillin-resistant Staphlococcus aureus) confuses cleanliness with the real failure in UK hospitals - poor hand hygiene and inadequate use of gloves, states an editorial in this week’s issue of The Lancet.

3 Apr 2005

Novel protein marker for early diagnosis of kidney failure

Researchers have found a novel protein marker that can give a rapid and early diagnosis of kidney failure in children undergoing heart surgery, reporting their results in this week’s issue of The Lancet.

3 Apr 2005

Directly observed therapy effective against drug resistant tuberculosis

Directly observed therapy (DOTS) - the main strategy for tuberculosis control - can rapidly reduce the transmission and incidence of the drug resistant form of the disease, concludes a study published in this week’s issue of The Lancet.

3 Apr 2005

Sexual behaviour alone doesn’t explain the differences in STIs among ethnic groups

Patterns of sexual lifestyles and sexually transmitted infections (STI) vary among ethnic groups in Great Britain, concludes a study in this week’s issue of The Lancet.

3 Apr 2005

Wolfowitz is the wrong choice for the World Bank

The nomination of Paul Wolfowitz to head the World Bank is the wrong choice and should be rejected, says an editorial in this week's BMJ.

3 Apr 2005

Not enough evidence that multivitamins prevent infections in the elderly

Role of multivitamins and mineral supplements in preventing infections in elderly people: systematic review and meta-analysis of randomised controlled trials BMJ Online First.

3 Apr 2005

British hospitals need clinical ethicists

"We need to introduce clinical ethicists in hospitals in the United Kingdom," says a researcher in medical ethics in this week's BMJ.

3 Apr 2005

The facts on prenatal care

The nine months of pregnancy come complete with a rich folklore, from guessing at a baby’s sex by the expectant mother’s shape to home remedies for morning sickness. Along with these ageless stories and advice, women also face a variety of recommendations from the modern world of medicine on how best to take care of themselves during pregnancy.

3 Apr 2005