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New microchip manipulates DNA and protein molecules

A Johns Hopkins undergraduate has constructed a new type of microchip that can move and isolate DNA and protein molecules. He believes that by linking the chip with analysis equipment, a user could identify medical ailments, monitor a patient's health or detect viruses and other biohazards before they spread.

22 Mar 2004

Government, industry, and academia focus on obesity

Amid shifting scientific data on nutrition and obesity, experts from government, industry, and academia converged on Harvard Medical School last week to discuss obesity's causes and how to craft a coherent public nutritional message.

22 Mar 2004

New optical glucose sensor could mean help for diabetics

Researchers at the University of California, Santa Cruz, have developed a novel optical glucose sensor that could be used to provide continuous monitoring of glucose levels in diabetics and hospitalized patients. Recently published studies showed that the sensor detects glucose under physiological conditions, giving a reversible fluorescent signal that changes intensity in response to changes in the concentration of glucose.

22 Mar 2004

New therapies that may treat cancers

Scientists at the Johns Hopkins Kimmel Cancer Center and Howard Hughes Medical Institute have found mutations in a gene linked to the progression of colon and other cancers. The research findings, may lead to new therapies and diagnostic tests that target this gene.

22 Mar 2004

Bacteria Live in the Esophagus!

The esophagus isn't merely a tube for food traveling from the mouth to the stomach, it also provides an environment for bacteria to live, according to a new study by NYU School of Medicine scientists that overturns the general belief that the esophagus is free of bacteria.

22 Mar 2004

Largest marketing campaign for a single drug to date

The cardiovascular market, one of the most hotly contested therapeutic areas of the pharmaceutical industry, continues to expand. Together, drugs that lower blood pressure and cholesterol treat 303 million potential patients worldwide. Nevertheless, companies that develop fourth or fifth to market drugs will struggle to compete, according to research by business intelligence firm Cutting Edge Information.

22 Mar 2004

Researchers find link that could aid in treatment of kidney cyst diseases

Researchers at UT Southwestern Medical Center at Dallas have uncovered a link between two cyst-forming diseases that affect the kidneys, a finding that could lead to treatments for both a rare form of diabetes and a common kidney disease.

22 Mar 2004

Treatment for ovarian cancer by gene targeting

Targeting and inactivating a key gene could be a subtle and effective treatment for certain types of ovarian cancer, Scottish researchers suggest in a study published in Clinical Cancer Research.

22 Mar 2004

New treatment for heart attacks

A team led by scientists at The Scripps Research Institute has developed a potential new treatment for heart attacks. The therapy inhibits fluid leakage from cardiac blood vessels following a heart attack and thereby significantly prevents long-term heart damage and improves survival.

22 Mar 2004

Tablet of Modafinil may improve a schizophrenics memory

Researchers from the Department of Psychiatry at the University of Cambridge recently identified a method of improving cognitive functioning in patients with schizophrenia, without the side-effects traditionally found with cognitive enhancers. Ms. Danielle Turner, together with colleagues from the University of Cambridge under the supervision of Prof. Barbara Sahakian, undertook research to explore the potential for a memory drug to improve cognition in patients with schizophrenia. The project received funding from the Wellcome Trust and the Medical Research Council. The work was published online on March 10 2004 at The American College of Neuropsychopharmacology website and is now in press in the journal Neuropsychopharmacology.

22 Mar 2004

£76 million research centre to make the UK a global centre of excellence for clinical imaging

GlaxoSmithKline (GSK) and Imperial College London today announce a unique research collaboration in medical imaging. GSK will contribute funding of £28m for the construction of a new Clinical Imaging Centre, next to Hammersmith Hospital in West London, UK. Research will focus on cancer, stroke, neurological diseases such as Parkinson's and multiple sclerosis and psychiatric diseases. In association with the Clinical Imaging Centre, GSK and Imperial have entered into a 10-year research agreement for medical imaging.

22 Mar 2004

Scientists identify blood development gene which may aid the fight against cancer and leukemia

Researchers at Harvard-affiliated Dana-Farber Cancer Institute have pinpointed a crucial gene on which the normal development of the body's entire blood system depends. If the gene is absent, even the most basic blood stem cells cannot be generated. In a mutated form, this gene can cause a rare and devastating form of leukemia.

22 Mar 2004

New Computer-Aided Approach Helps Doctors Tailor The Dosage of Abciximab

A computer-aided approach -- based on software-that-learns, promises to provide a new tool that helps doctors tailor the dosage of abciximab, a medicine frequently used before angioplasty to lessen the chance of heart attack.

22 Mar 2004

New Theory About Alzheimer's Disease

A group of scientists at The Scripps Research Institute has proposed a new theory about the cause of Alzheimer's disease, the progressive neurodegenerative disorder that currently afflicts some 4.5 million Americans. According to the hypothesis, the disease arises as a consequence of inflammation, which creates abnormal metabolites out of normal brain molecules.

22 Mar 2004

Drug Based on Brain Chemical Could End Narcolepsy and Insomnia

Researchers at UT Southwestern Medical Center at Dallas have discovered a potentially new avenue for treating human narcolepsy, and the work may also lead to more effective ways for insomniacs to boost their wakefulness during the daytime.

22 Mar 2004

Obesity Drug Inhibits Prostate Tumor Growth

The Burnham Institute's Jeffrey Smith, Ph.D. has discovered that orlistat, commonly prescribed as an anti-obesity drug, has a positive side-effect: it inhibits cancer growth. Dr. Smith made this discovery using an activity-based proteomics screening technique developed in his laboratory that makes it possible to identify active targets and simultaneously screen for their inhibitors.

22 Mar 2004

Cigarette Smoking May Lower Rates of Neurodegenerative Diseases like Parkinson's and Alzheimer's

While the health risks of tobacco are well known, several studies have shown that people with a history of cigarette smoking have lower rates of neurodegenerative diseases like Parkinson's and Alzheimer's disease. However, the explanations for nicotine's neuroprotective effects continue to be debated.

22 Mar 2004

Gene Responsible for The Most Common Form of Diabetes

International research teams studying two distinct populations have found variants in a gene that may predispose people to type 2 diabetes, the most common form of the disease. The researchers, who collaborated extensively in their work, report their findings in companion articles in the April issue of Diabetes.

22 Mar 2004

Stem cells and female reproduction: lessons from an unexpected source

Baltimore, MD. The recent findings reported in Nature (March 11, 2004) by Jonathon Tilly’s group at Harvard Medical School, show that female mice produce stem cells that give rise to eggs. This result overturns previous notions about mammalian reproduction, which held that females are born with all the eggs that they will ever have and that the decline in egg quality that occurs after a certain age is due to an extended aging process. What mammalian research has not been able to address at this point, however, is how these stem cells operate, what prompts them to develop into eggs, and why they are eventually lost. To answer these questions we must turn to our cousin the fruitfly.

22 Mar 2004

Molecules That Trigger a Heartbeat

Two biomedical engineering students at Johns Hopkins are mapping the interaction of molecules within a cardiac cell, describing microscopic movements that could be critical for maintaining a healthy heartbeat. The students, seniors Bhuvan Srinivasan and Carol Xiaoying Koh, have presented their findings at two prestigious computational biology conferences and are now collaborating with their faculty supervisor on a paper for a scientific journal.

22 Mar 2004