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Discovery of gender difference in cartilage cells may help spinal disc repair

When biologist Barbara Boyan discovered science’s first proof of biochemical differences between male and female cartilage cells, she began to question the approaches she and other researchers were taking to study cells. Was their thinking biologically relevant?

30 Mar 2004

FDA has approved Zyprexa, injectable anti-psychotic drug

Physicians have a new fast-acting option for controlling the potentially crippling effects of acute agitation in patients suffering with schizophrenia and bipolar mania. The U.S. Food and Drug Administration (FDA) has approved Zyprexa® IntraMuscular (olanzapine for injection), an injectable form of Lilly's top-selling medication.

30 Mar 2004

Faster new cloning technique - transcript-based cloning

A single strand of plant or animal DNA may contain tens of thousands of genes, each programmed to produce a specific protein essential for the growth or survival of the organism. The challenge for geneticists is to isolate individual genes and determine their function – a painstaking process often requiring years of laboratory trial and error.

30 Mar 2004

Lack of iodine prompts new Australian study

A fear that Australians could be suffering serious ill effects from lack of iodine in their diets has prompted a new study of New South Wales, Riverina residents by Charles Sturt University’s (CSU) School of Biomedical Sciences.

30 Mar 2004

Embryonic stem cells attached to a gel matrix instead of suspended in solution

30 Mar 2004

Natural compound in snake venom for treatment of malignant tumours

Researchers at the University of South Australia have made a major discovery using a natural compound in snake venom that shows very promising anti-cancer effects. The compound works by activating the destruction of cells which make up the blood vessels that supply nutrients to tumours, according to Associate Professor Tony Woods from UniSA’s School of Pharmaceutical, Molecular and Biomedical Sciences.

30 Mar 2004

New research suggest that steroid treatment for osteoarthritis knee suffers may not progress disease as previously thought

Steroid treatment for osteoarthritis knee suffers was thought to progress the disease, but that belief has been overturned following a review of the literature by researchers at The University of Auckland. Associate-Professor Bruce Arroll, from the School of Population Health at the University, says that osteoarthritic knee pain is one of the leading causes of disability amongst older people.

30 Mar 2004

Removal of thyroid glands may be unnecessary for most patients

An unpleasant postoperative procedure for thyroid cancer patients who have had their thyroid glands surgically removed may be unnecessary for most patients, according to Washington University researchers at Siteman Cancer Center and Barnes-Jewish Hospital in St. Louis.

30 Mar 2004

Aspirin surgery on neck arteries can prevent complications

Popping an aspirin the night before you are due to have surgery on neck arteries could help prevent a dangerous complication, a team of researchers at the University of Leicester has discovered.

30 Mar 2004

Scientists find parallels between human speech and bird song which gives clues to human speech disorders.

The research by a team led by Stephanie White, UCLA assistant professor of physiological science, supports the theory that two genes shared by humans and songbirds, FoxP1 and FoxP2, may play a critical role in human speech, and speech disorders. The study is published March 31 in the Journal of Neuroscience.

30 Mar 2004

Zebrafish show effects of ionizing and UV radiation differ during embryo development

Adam Dicker, M.D., Ph.D., associate professor of radiation oncology at Jefferson Medical College of Thomas Jefferson University and Jefferson’s Kimmel Cancer Center in Philadelphia, Mary Frances McAleer, M.D., Ph.D., a resident in the Department of Radiation Oncology at Jefferson Medical College and their co-workers compared the effects on zebrafish embryos of two types of radiation – ionizing radiation, which is the kind given to patients for cancer treatment, and ultraviolet (UV) radiation, which comes naturally from the sun.

30 Mar 2004

Discovery of novel gene profile that may identify colon stem cells

Researchers at Jefferson Medical College have uncovered a novel pattern of gene expression in the stem cell-rich bottom of tiny “crypts” in the tissue lining the colon. By identifying these patterns, the scientists hope to be able to identify mechanisms through which stem cells contribute to the development of colon cancer.

30 Mar 2004

£1.6m for research into a possible cure for muscular dystrophy

A consortium which includes Oxford researchers has won £1.6m in government funding for ground-breaking research into a possible cure for muscular dystrophy.

30 Mar 2004

First Canadian therapeutic HIV vaccine trial

Clinicians from the McGill University Health Centre and the Centre hospitalier de l'Université de Montréal (CHUM) are participating in the first Canadian therapeutic HIV vaccine trial. Funded by a number of public and private institutions, including the Canadian Network for Vaccines and Immunotherapeutics (CANVAC) and the Canadian Institutes of Health Research, this project will begin in April.

30 Mar 2004

Newly diagnosed non-Hodgkin’s lymphoma linked to monkey virus DNA

Examination of tumors in patients with newly diagnosed non-Hodgkin’s lymphoma found that half of them show evidence of a monkey virus DNA that may have originated from contaminated polio vaccines.

30 Mar 2004

Human Genome Sciences can begin cardiovascular disease research

Human Genome Sciences, Inc.announced today that it has received a clinical development milestone payment from its partner, GlaxoSmithKline, related to the initiation of Phase 1 clinical trials of 677116 for the treatment of cardiovascular disease. 677116 is a small-molecule inhibitor of lipoprotein-associated phospholipase A2 (Lp-PLA2), an enzyme associated with the formation of atherosclerotic plaques.

30 Mar 2004

Extraction of RNA from Archived Formalin-Fixed, Paraffin-Embedded Tissue

For the first time, Fox Chase Cancer Center researchers have demonstrated the ability to extract RNA from formalin-fixed, paraffin-embedded tissue samples archived for up to five years. What's more, the technology used retrieves high-quality samples, allowing researchers to identify cancer-related genetic changes. Accepted as a "late-breaking" abstract, the research was presented today at the 95th Annual Meeting of the American Association for Cancer Research by Renata Coudry, M.D., a research pathologist at Fox Chase Cancer Center.

30 Mar 2004

Novel uses for bacterial cellulose, artificial blood vessels, bioengineered wound dressing

New and unique products created from bacterial cellulose — from electronic paper to treatment for wounds — will highlight a one-day symposium at the 227th national meeting of the American Chemical Society, the world's largest scientific society.

30 Mar 2004

Biocompatible adhesives for use with vascular tissue that will speed the process of mending tissue

Surgeons battle time and the body's defenses as they stitch together veins and arteries, whether after an injury or in the course of such treatments as transplants or bypasses. Loss of blood before a site is closed and too much clotting soon after challenge medical care.

30 Mar 2004

New storage method amplifies cells available for science

Like many other kinds of cells used in biomedical research, human embryonic stem cells are stored and transported in a cryopreserved state, frozen to -320 degrees Fahrenheit, the temperature of their liquid nitrogen storage bath. But when scientists thaw the cells for use in the lab, less than 1 percent awake from their frigid slumber and assume their undifferentiated state. This 'blank slate' form is characteristic of stem cells and essential for the basic science required before the promising cells are ready for the clinic.

30 Mar 2004