Researchers discover way to reduce plaque deposits on the brain that could slow the progression of Alzheimer's disease

May 26 2005

University of Florida researchers have discovered a way to reduce plaque deposits on the brain that could slow the progression of Alzheimer's disease. Their findings, which will be highlighted at the upcoming 2005 American Association of Pharmaceutical Scientists' (AAPS) National Biotechnology Conference in San Francisco, brings renewed hope to the 4.5 million Americans who have Alzheimer's disease.

"This is the first time this approach has been used to treat Alzheimer's disease," said Jeffrey Hughes, Ph.D., of the University of Florida College of Pharmacy. "After only one injection, the plaque on the brain has stopped forming."

For years scientists have recognized a connection between plaque deposits on the brain and the progression of Alzheimer's disease. Plaque deposits are formed when amyloid precursor protein (APP), found widely throughout the body, releases itself into fragments, called beta-amyloids, which in turn form plaque.

While other scientists have been researching ways to prevent plaque from depositing, the University of Florida team sought to reduce plaque by using a naturally occurring human-binding protein, gelsolin, to absorb the beta- amyloids. Preliminary data from the National Institute of Aging-sponsored research reveals that gelsolin has succeeded in reducing amyloid deposition by as much as two-thirds to three-quarters.

"We are excited by the preliminary results," Dr. Hughes said. "We look forward to further testing our approach to see if gelsolin continues to act as a sponge, absorbing and reducing plaque and ultimately affecting the progression of Alzheimer's disease."

The AAPS National Biotechnology Conference is an annual event incorporating all aspects of the pharmaceutical sciences and providing an open forum for discussion of hot industry topics. The conference will take place at the San Francisco Marriott, June 5 - 8. Dr. Hughes and Aaron Hirko will present the team's findings during a poster session held on Monday, June 6, 2005 11:30 am - 12:30 pm in Yerba Buena Salons 2 - 6.