High exposure to the sun halves risk of prostate cancer

Jun 16 2005

Cancer researchers in the U.S. say that high exposure to the sun halved the risk of prostate cancer in men participating in a U.S. trial.

They say this is likely because of their body’s higher vitamin D stores.

The researchers led by Esther John of the Northern California Cancer Center, say that if future studies continue to show that sunlight lowers prostate cancer risk, men may be advised to increase their vitamin D intake from diet and supplements as a safer option to sunbathing.

They say that in men with certain gene variants, high sun exposure reduced prostate cancer risk by as much as 65 per cent.

Previous research had also shown that the prostate uses vitamin D to promote the normal growth of prostate cells and to inhibit the invasiveness and spread of prostate cancer cells to other parts of the body.

Co-author Gary Schwartz of Wake Forest University, says the genes involved are those that determine the type of vitamin D receptors a person has, and the receptors, which function with vitamin D like a lock and key, vary in their ability to bind vitamin D and thus to influence cell behaviour.

The researchers say that although the body manufactures the active form of vitamin D from exposure to sunlight, men should not try to reduce their risk of prostate cancer by sunbathing because that increases the risk of sun-induced skin cancer, especially melanoma.

In future, increasing vitamin D intake from diet and supplements may be the safest solution to achieve adequate levels of vitamin D.

In the trial, 450 non-Hispanic white patients in the San Francisco Bay, area who had advanced prostate cancer were compared with a matched control group of 455 men who did not have prostate cancer.

The scientists measured sun exposure by comparing pigmentation of underarm skin, which is usually not exposed to sunlight, with forehead pigmentation, which is, using a portable reflectometer.

Because it is hard for the sun to reach the underarm area, there was no difference in the underarm measurement between the prostate cancer cases and the control group, but when the forehead colour was compared to the underarm colour, the control group had significantly darker pigmentation than the cancer patients.

The team say increasing darkness was associated with a trend of decreasing risk of prostate cancer.

The scientists also obtained a sun exposure history from each participant so they could track outdoor activity and they found that a reduced risk of advanced prostate cancer was associated with high sun exposure determined by 'reflectometry and high occupational outdoor activity'.

They say further studies in large populations, including non-whites, are needed to confirm their findings.

According to the International Agency for Research on Cancer (IARC), the disease is the second most common cancer in men after lung cancer.

It was the most common form of cancer diagnosed among men in the European Union during 2004, representing 15 per cent of male cancers and 238,000 new cases, according to the IARC.

The study is published in the current issue of Cancer Research.