Gene variant doubles risk for obsessive-compulsive disorder

Apr 11 2006

Scientists at the National Institute on Alcohol Abuse and Alcoholism (NIAAA) have identified a previously unknown gene variant that doubles an individual's risk for obsessive-compulsive disorder (OCD).

The new functional variant, or allele, is a component of the serotonin transporter gene (SERT), site of action for the selective serotonin reuptake inhibitors (SSRIs) that are today's mainstay medications for OCD, other anxiety disorders, and depression.

"Improved knowledge of SERT's role in OCD raises the possibility of improved screening, treatment, and medications development for that disorder," said Ting-Kai Li, M.D., Director, National Institute on Alcohol Abuse and Alcoholism. "It also provides an important clue to the neurobiologic basis of OCD and the compulsive behaviors often seen in other psychiatric diseases, including alcohol dependence."

Approximately 2 percent of U.S. adults (3.3 million people) have OCD, the fourth most prevalent mental health disorder in the United States. Individuals with OCD have intrusive, disturbing thoughts or images (obsessions) and perform rituals (compulsions) to prevent or banish those thoughts. Many other individuals demonstrate obsessive-compulsive behaviors that do not meet OCD diagnostic criteria but alter the individuals' lives.

Drs. David Goldman, Chief, and Xianzhang Hu, Research Scientist, in NIAAA's Laboratory of Neurogenetics discovered the linkage aided by new functional analyses of the SERT genetic variant. The researchers first compared the genotypes of 169 OCD patients to those of 253 controls in a large U.S. patient population and found that the OCD patients were twice as likely to have the variant. Then they studied transmission and non-transmission of the variant in a Canadian population of 175 OCD parent-child trios (two healthy parents and a child with OCD) and found that the risk variant was twice as likely to be transmitted from a parent to a child with OCD. Specifically, of 86 informative trios, 48 children carried the new risk variant and 26 did not.

"Whereas most genetic diseases are caused by variations that lead to reduced gene function, we found that a common SERT variant that increases SERT activity also increases risk for OCD," said Dr. Goldman. The same research team previously identified a rare gain-of-function variant at a different location in SERT. It, too, is linked to OCD but has been studied only in two families with a severe, treatment-resistant form of the disease. "That earlier study suggested that we should test the common gain-of-function variant for OCD linkage," Goldman said.

The new variant is located at a well-recognized site in the SERT gene. Also known as HTTLPR, the site is the most heavily studied polymorphic site (those that may display differing DNA sequences) in psychiatric genetics. For years, HTTLPR has been known to have two variants--S and L--that alter expression of the SERT gene and are common across all human populations. The loss-of-function S variant exerts a small effect on a person's risk for anxiety, depression, and suicidality, especially in response to environmental stressors. The S allele exerts a larger effect on the intermediate neurobiology of anxiety and depression, specifically, by disrupting the structure and functional coupling of key brain regions. The gain-of-function L allele, on the other hand, enhances SERT activity and functional coupling. The current study differentiates the L variant into two--LA and LG--and shows that LA exerts a greater influence on SERT expression.

"The gain-of-function L alleles appear to inhibit connections between emotion and repetitive behaviors and such executive brain functions as task-switching," Goldman said. "These neurobiology relationships should be further tested in combined genetic-neuroimaging studies."