Infertility is a growing problem

Infertility will become more prevalent in generations to come, but interpreting these trends is complicated, say researchers in this week's BMJ.

Infertility is a common problem in affluent societies, write experts from Aarhus University Hospital Denmark and the University of California in an editorial. It affects around 15% of couples trying to conceive, although not all seek medical help.

In some countries, up to 6% of children are conceived through assisted reproductive techniques.

But examining changes in fecundity over time is difficult, say the authors, because fertility is determined by social, behavioural, and biological factors that cannot be reliably ascertained in studies based on retrospectively collected data.

These cultural and social norms may mask more subtle biological changes in the population.

More direct markers of fecundity are urgently needed, they say, and the time has probably come to include fecundity in ongoing representative health surveys.

They predict that fecundity is expected to decline over time, even if no environmental causes are identified. This is because, with the advent of assisted conception, subfertile couples may have as many children as fertile couples, so genetic factors linked to infertility will become more prevalent in the generations to come.

The best way to counteract infertility and help couples to have children naturally is to deal with the avoidable causes of subfecundity, say the authors, and there are good grounds for promoting further research and for trying to make up for the many years during which research into infertility has been neglected.

The endocrine disruption hypothesis – which states that environmental chemicals may cause adverse development of sexual organs by interference with hormonal regulation – is just one of many hypotheses that deserve attention from funding agencies, they conclude.

http://www.bmj.com