3M Drug Delivery System collaborates on vaccine adjuvants

May 1 2008

3M Drug Delivery Systems announces the signing of a non-exclusive license agreement with the Infectious Disease Research Institute (IDRI) in support of vaccine research for humanitarian efforts in developing countries. Under the agreement, 3M will donate its patented toll-like receptor (TLR) immune response modifier compounds.

3M's patented TLR immune response modifier compounds, which may be useful as vaccine adjuvants, will be used by IDRI to research new vaccines. Vaccine adjuvants are known to help boost the effectiveness of a vaccine.

"IDRI's vaccine platform has the potential to prevent and treat a number of important diseases in the developing world. By providing our vaccine adjuvant compounds to their vaccines, we are providing a cost-effective way for IDRI to conduct vaccine research," said Dr. Mark Tomai, PhD, Vaccine Business Development, 3M Drug Delivery Systems. "This will help them and us learn more about the potential effectiveness of our vaccine adjuvants. We anticipate this collaboration with IDRI to be the first in many deals around our TLR vaccine adjuvant portfolio."

3M's TLR compounds, also called TLR7 and TLR8 agonists, are small organically synthesized molecules that offer flexibility in formulating and route of delivery, and ease in manufacturing, unlike most other TLR agonists, which are much larger and not as easy to manufacture.

"IDRI's access to a 3M compound provides us with a very important tool for our efforts to develop adjuvants to be used in vaccines for diseases of global impact," says Steve Reed, IDRI's Founder and Head of Research. "We are very pleased that 3M has demonstrated this confidence in our organization-and are confident that IDRI's access to the 3M technology will improve our vaccine research and development."

"Our toll-like receptor agonist platform is a major part of our vaccine offering that also includes our Microstructured Transdermal System(a) for needle-free delivery of vaccines. We are at the start of a positive relationship that pairs our unique technology with a critical global need. We look forward to working with IDRI on its vaccine research," said Dr. Steven Wick, Technical Director, 3M Drug Delivery Systems.