TransPharma's Phase 2A trial of ViaDerm-hPTH(1-34) for treating severe osteoporosis is successful

Sep 1 2009

TransPharma Medical Ltd., a specialty pharmaceutical company focused on the development and commercialization of drug products utilizing a proprietary active transdermal drug delivery technology, announced today the successful completion of the Phase 2A trial of ViaDerm-hPTH(1-34) which is being developed for the treatment of severe osteoporosis.

In June 2008, Eli Lilly and Company and TransPharma entered a licensing and development agreement relating to TransPharma’s ViaDerm-hPTH(1-34) product for the treatment of severe osteoporosis. As part of this project, TransPharma has completed a three-month Phase 2A trial for transdermal PTH(1-34). The primary and secondary endpoints for efficacy and safety were met. The safety endpoints included a skin safety endpoint for repeated dosing with the ViaDerm system. More details of the phase 2A study results are expected to be shared during 2010 in one of the leading Osteoporosis conferences. Initiation of a dose-ranging Phase 2B study to be jointly conducted by Eli Lilly and TransPharma is planned for later this year.

"We are very pleased with the results of this trial, which demonstrate remarkable progress in the use of the ViaDerm system in clinical trials," said Dr. Daphna Heffetz, CEO of TransPharma Medical. "We have met the primary and secondary endpoints of the phase 2A trial. We are looking forward to the Phase 2B trial, and hope that, in the future, we will be able to improve therapy for people suffering from osteoporosis by offering an alternative to daily injection of PTH.”

About ViaDerm Drug Delivery System

TransPharma’s ViaDerm drug delivery system incorporates a handheld electronic device, which creates microscopic passageways through the outer layer of the skin allowing for transdermal delivery of a wide variety of drugs from a patch. The system provides a cost-effective, easy-to-use, self-administered solution that enables the safe, reproducible and accurate delivery of a broad range of product candidates, including hydrophilic small molecules peptides and proteins.