Phase II clinical trial of TAK-700 for treating advanced prostate cancer commences

Sep 11 2009

Takeda Pharmaceutical Company Limited (TSE:4502) and its wholly-owned subsidiary Millennium: The Takeda Oncology Company today announced the initiation of the Phase II portion of a Phase I/II clinical trial of TAK-700 in patients with advanced prostate cancer. TAK-700 is a non-steroidal androgen synthesis inhibitor that in preclinical studies has been shown to selectively bind to and inhibit the enzyme 17, 20 lyase¹ in both the testes and adrenal glands, suppressing the production of androgen.

The open-label, multiple-dose study will examine the safety and effectiveness of TAK-700 in patients with chemotherapy-naïve metastatic castration-resistant prostate cancer. Primary endpoints of the study are safety and tolerability with secondary measures to include efficacy, pharmacokinetic and pharmacodynamic endpoints.

“Our efforts in the development of drugs for prostate cancer represent a high-priority for Millennium,” said Nancy Simonian, M.D., Chief Medical Officer, Millennium. “TAK-700 is the first drug candidate in our prostate program to advance to Phase II clinical trials. We are pleased to see the progress of this compound, and we are striving to develop drugs that will fulfill the unmet medical need for prostate cancer.”