Online patient support program for ADHD patients taking Vyvanse Capsules CII medication

Shire plc (LSE: SHP, Nasdaq: SHPGY), the global specialty biopharmaceutical company, today announced the re-launch of FOCUS (http://www.vyvanseFOCUS.com), a free, online patient support program for adults taking once-daily Vyvanse® (lisdexamfetamine dimesylate) Capsules CII for the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD), and the only online, branded personalized patient support program providing tips and tools for adults diagnosed with ADHD taking a prescription medication.

FOCUS is designed for the individual needs of adults with ADHD who are taking Vyvanse by letting them choose the tips and tools in the areas that most impact their life. These tips suggest organizational strategies designed to help adults during their busy day. Each adult patient taking Vyvanse has the option to enroll in FOCUS at http://www.vyvanseFOCUS.com and receive:

• Customized practical tips relevant to their needs
• Reminders to help plan their days, including remembering upcoming appointments and Vyvanse prescriptions
• A timer to help allocate blocks of time to finish large projects at work
• A white noise player to help drown out distractions

"In today's fast-paced environment, each day can bring new responsibilities and challenges both in the workplace and at home. For an adult with ADHD, these responsibilities can quickly become overwhelming," said Michael Yasick, Senior Vice President of the Shire ADHD Business Unit. "FOCUS was born out of the understanding that each patient manages his or her day differently. FOCUS provides customized support for patients taking Vyvanse, so that in addition to working with their doctor on a comprehensive treatment plan, patients also have a resource for helpful tips that they can use throughout their day both at work and at home."

Vyvanse is indicated for the treatment of ADHD in children aged 6 to 12 and in adults with ADHD. The most common side effects reported in studies of Vyvanse in adults were decreased appetite, difficulty falling asleep and dry mouth. The symptoms of ADHD in adults, such as inattention, hyperactivity, and impulsivity, may result in having trouble focusing, avoiding tasks that require sustained mental efforts, or frequently losing things.