DTI helps identify distorted nerve fiber bundles around brain tumors in thalamic JPA children

Dec 5 2009

A new study published this week in the Journal of Neurosurgery: Pediatrics finds that operative plans for removing Juvenile Pilocytic Astrocytoma, or JPA, tumors in the thalamus of the brain can be augmented with Diffusion Tensor Imaging, or DTI. The sensitivity of DTI imaging allows for the visualization of nerve fiber bundles in the brain. This information can maximize the potential of completely removing the tumor while avoiding damage to the fiber bundles that are directly related to motor functions of the patient.

"This study of six children with thalamic JPA showed that using advanced MRI technology can help identify distorted nerve fiber bundles around brain tumors," said Jeffrey H. Wisoff, MD, director of the Division of Pediatric Neurosurgery at NYU Langone Medical Center. "This allows an otherwise inoperable tumor to be completely removed which can hopefully lead to a cure."

Operating on patients with deep-seated tumors such as JPA, a benign tumor most frequently observed in children and young adults in the thalamus, remains a neurosurgical challenge. Conventional imaging techniques, such as structural MRI, has been revolutionary in helping to reveal major anatomical features of the brain, primary gray matter which is made up of nerve cell bodies. Diffusion Tensor Imaging, a variation of MRI, can help identify white matter, or nerve fiber bundles, using specific radio-frequency and magnetic field pulses to track the movement of water molecules of the brain. In most brain tissue, water molecules diffuse in all different directions. But they tend to diffuse along the length of axons, whose coating of white, fatty myelin holds them in. Scientists can create pictures of axons by analyzing the direction of water diffusion.

Source NYU Langone Medical Center