Pall Corporation (NYSE: PLL), a global leader in filtration, separation
and purification, has introduced the PallSep Biotech system for the
gentle separation of target molecules from complex biotechnology process
fluids. The new system utilizes vibrating membrane filtration (VMF)
technology and encapsulated hydrophilic polyethersulfone membrane filter
modules. This unique combination reduces the accumulation of retained
species on the membrane surface which allows for increased transmission
of the target molecule.
“The new PallSep Biotech system expands processing options by allowing
users to combine different process steps such as harvest and
clarification within the same system, thus simplifying the process
design”
The VMF principle is based on the rapid oscillation of porous membrane
plates within a process feed stream to create shear at the membrane
surface. The generated shear forces are limited to a narrow portion of
the flow channel, reducing the amount of process fluid exposed to the
shear. The cross flow requirements are much lower with the PallSep
Biotech system than with other tangential flow filtration (TFF)
technologies. This creates gentle processing and good product
transmission.
The PallSep Biotech system supports the production of high value
products like therapeutic vaccines and antigen extracts. It permits the
concentration, clarification and purification of feed streams with high
levels of biomass particulates and viscosity, along with
difficult-to-filter solutions such as fermentation broths and lysates.
“The new PallSep Biotech system expands processing options by allowing
users to combine different process steps such as harvest and
clarification within the same system, thus simplifying the process
design,” said Nathalie Pathier, TFF product manager, Pall Life Sciences.
“The stable permeate flow and improved protein transmission we can
achieve with this technology contribute to better process economics.”
The encapsulated 0.2 µm polyethersulfone membrane filter modules,
available in filter areas of 0.2, 1 and 5 m2, offer
flexibility for scale up and scale down of processes. Typical batch
sizes range from a few liters to 500 liters, depending on the process
application.
Custom designed for specific requirements, the PallSep Biotech system
can be operated manually or within an automated process. It includes all
valves, pumps, sensors, vessel and piping elements in a process system.
GMP requirements for biopharmaceutical processes are met without
compromising ease of use, flexibility, cleanability, safety or operating
costs.
SOURCE Pall Corporation