SickKids receives $8.9M grant for autism research

A research team co-led by Dr. Stephen Scherer, Senior Scientist at The Hospital for Sick Children (SickKids) was awarded an $8.9 million grant today from the Global Leadership Round in Genomics & Life Sciences (GL(2)), which is part of the Ontario Research Fund (ORF) by the Ministry of Research and Innovation (MRI).

Scherer, Director of The Centre for Applied Genomics at SickKids and the McLaughlin Centre at the University of Toronto, along with co-principal investigator Dr. Peter Szatmari, Vice-Chair of Research and Professor at McMaster University, are studying the genomic basis of autism spectrum disorder (ASD). ASD is a neurological disorder resulting in developmental challenges connected to communication, social understanding and behaviour.

The project, called Autism Spectrum and Associated Neurodevelopmental Disorders: Genomes to Outcomes, is geared towards developing new tools to screen genomes and generating cutting-edge technologies to diagnose ASD and other neurological disorders. This work builds on previous research in which the scientists had identified gene copy number differences to be involved in ASD susceptibility. In what will be the largest study of its kind, they will now be using advanced technology to sequence genes from thousands of ASD patients in Ontario.

"Our goal is to bring our gene discoveries from the research labs to clinics, which we believe will facilitate the necessary early diagnosis critical for successful intervention in ASD," says Scherer.

Life Technologies Corporation, a global biotechnology tools company and continued partner of SickKids for its SOLiD technology, will also be a key collaborator for this research. Following today's government announcement, the company has committed to a $700,000 investment in the form of a next-generation DNA sequencing instrument. SickKids has previously purchased two SOLiD Systems for a variety of genomic projects.

"Life Technologies is pleased to partner with Dr. Scherer and his colleagues to support their research, which may lead to the development of new approaches for understanding complex human diseases like autism, and is proud to be collaborating with SickKids on sequencing technology that supports their research," says John L. Miller, President, Genetic Systems Division at Life Technologies. "The unique and superior accuracy of the SOLiD System is ideal for research targeted at elucidating the heterogeneous genetic variations implicated with ASD. We are confident that by working together with SickKids, progress will continue to be made towards understanding the underlying genetic factors in ASD."

Scherer notes that "this is a wonderful example of how collaboration with government and industry partners could help achieve the ultimate goal of easing the lifelong challenges faced by ASD families."

The government funding is part of Ontario's $114 million commitment to genomics and gene-related research through the ORF's GL(2) program.

Source: HOSPITAL FOR SICK CHILDREN