Positive microplasmin Phase II trial results published in journal Retina

- Paper Highlights the Potential of Microplasmin for Nonsurgical Treatment of Vitreomacular Adhesion

ThromboGenics NV (Euronext Brussels: THR), a biopharmaceutical company focused on the discovery and development of innovative treatments for eye disease, vascular disease and cancer, announces today that positive microplasmin Phase II trial results, evaluating the product for the nonsurgical treatment of vitreomacular adhesion, have been published in the July/August issue of the journal Retina.

The paper is entitled "Intravitreal Injection of Microplasmin for Treatment of Vitreomacular Adhesion - Results of a Prospective, Randomized, Sham-Controlled Phase II Trial (The MIVI-IIT Trial)." The results show that microplasmin was generally well tolerated, and support its potential for nonsurgical resolution of vitreomacular adhesion. For a full discussion of the results from this Phase II trial, please refer to the Retina article.

Based on these positive results, along with the positive results of the MIVI III trial (previously published in the journal Ophthalmology), the Phase III program MIVI-TRUST was performed. The MIVI-TRUST program included two trials, the TG-MV-006 and TG-MV-007 studies. Positive data from the first Phase III trial of microplasmin (TG-MV-006) were previously disclosed at the World Ophthalmology Congress in June. Details of these results can be found in the press release dated 7 June 2010, available at http://www.thrombogenics.com.

Results from the second Phase III trial (TG-MV-007) for the non-surgical treatment of vitreomacular adhesion (VMA) are to be presented at the Annual Meeting of the American Society of Retina Specialists (ASRS) and the European Society of Retina Specialists (EURETINA Congress).

The schedule of presentations for both upcoming conferences is as follows: ASRS (28 August - 1 September in Vancouver, BC, Canada). - TG-MV-007 results presented by Dr. J. Michael Jumper of West Coast Retina and U.C. San Francisco (California, USA) on August 31. - TG-MV-006 data presented by Dr. Kirk Packo of Rush University Medical Center, Chicago, Illinois, USA on August 31. EURETINA (2-5 September in Paris, France). - TG-MV-007 results presented at the main session of the Congress by Professor Peter Stalmans of University Hospitals Leuven, Belgium, lead investigator of the TG-MV-007 trial on September 4. - TG-MV-006 data presented by Dr. Victor Gonzalez of Valley Retina Institute, Texas, USA on September 3.

Professor Peter Stalmans, lead investigator of the MIVI IIT study and lead author of the Retina publication, commented, "I am very pleased that these highly interesting Phase II results with microplasmin have been published in such an important journal as Retina. The excitement that microplasmin generated at the time of the Phase II results has continued, with the positive data reported in the first study of the Phase III trial program. I very much look forward to presenting the upcoming results of the second Phase III trial at EURETINA in September, a study which I hope will again show microplasmin's potential to offer an effective, convenient, non-surgical treatment option for a range of retinal diseases."