UC San Diego receives grant to study hypoxia susceptibility

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University of California -- San DiegoSep 24 2010

Gabriel G. Haddad, MD, chair of the Department of Pediatrics at the University of California, San Diego School of Medicine and Physician-in-Chief at Rady Children's Hospital-San Diego has received a $10 million grant from the National Institute of Health's Heart, Lung and Blood Institute.

A world renowned physician-scientist in pediatric pulmonary medicine, Haddad will lead a collaborative team of investigators from UC San Diego and the Sanford-Burnham Medical Research Institute to study the impact of low oxygen levels on cells and tissue in the heart, lung, and brain.

"Understanding the molecular, cellular, and genetic mechanisms that contribute to low oxygen tolerance or susceptibility will have a major impact on our treatments of central nervous system and cardio-respiratory diseases such as stroke, myocardial ischemia/infarction, obstructive sleep apnea and pulmonary hypertension," said Haddad.

The overall aims of this project are:

To study the adaptive mechanisms to hypoxia in cardiovascular and respiratory systems at both cellular and molecular levels
To study the fundamental genetic mechanisms of tolerance in a Drosophila (fruit fly) model
To modulate or manipulate molecular mechanisms in mammalian cells/tissues/animals to render them hypoxia-tolerant after learning from a tolerant organism, e.g., the fly
To identify molecular signatures of hypoxia tolerance and susceptibility that may be predictive clinically

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University of California -- San Diego

Posted in: Medical Research News | Medical Condition News

Tags: Blood, Brain, Cardiology, Central Nervous System, Children, Fruit, Genetic, Heart, Hospital, Hypertension (High Blood Pressure), Hypoxia, Lungs, Mammalian Cells, Medical Research, Medicine, Nervous System, Obstructive Sleep Apnea, Oxygen, Pediatrics, Pulmonary Arterial Hypertension, Pulmonary Hypertension, Research, Respiratory, Sleep, Sleep Apnea, Stroke

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asleep at the wheel

chris says:

September 29, 2012 at 6:20 PM

I recently was informed that upon birth I was suffocated, due to the quickness of my mother's delivery and her size. I suffered throughout my life with issues that fits the description of hypoxia at birth.Later on in life, I had developmental problems and didn't walk till I was 22 months. I had speech problems and had difficulties in reading and communication. I had coordination problems and simple cognitive issues.
Early in my life,that is in my preteen years, I showed much aptitude for mathematics and writing. I failed to apply myself,but attended college struggling,eventually received a bachelor of science degree from the University of California. Mathematics had me feeling like a mathophobic, but I found the answers without working the problems. I never figured it out exactly, but feel that I was able to overcome many of these obstacles. I work in science, have done many kinds of things.I have strong passions, and I consider myself a master of nothing(which isn't really true) and a jack of all trades. I would be interested to participate in any analyses of my type/condition.
I travel to San Diego two or three times a year. I am 64 years old and to the best of my knowledge, and in good health. I can be reached through this site. I look forward to hearing from you in regards to a discussion or interview regarding this lifelong struggle.

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