Boehringer Ingelheim's selection of development candidate triggers € 6.5 million milestone payment to Orexo

“The medical need in the area of pain and inflammation is considerable and this collaboration has the potential to address the patients' and physicians' need for a new treatment regarding safety and efficacy.”

Orexo AB (STO: ORX) and Boehringer Ingelheim announced today that Boehringer Ingelheim has selected a development candidate resulting from the worldwide exclusive research, development and commercialisation agreement which Boehringer Ingelheim had signed in November 2005 with Biolipox, a Swedish research-based pharmaceutical company acquired by Orexo in October 2007. The aim of the collaboration is to develop a new class of medication with a novel mechanism of action for the treatment of pain and inflammatory diseases. The selection of a development candidate has triggered a milestone payment of € 6.5 million (59 mSEK) to Orexo.

The terms of the agreement foresee further potential milestone and royalty payments. Boehringer Ingelheim is responsible for all further compound development and marketing. In the Nordic and Baltic countries Orexo has the option to co-promote the products arising from this collaboration. The co-promotion option would enable Orexo to build up its own commercialisation capabilities within the field of inflammatory pain.

The collaboration is focused on Orexo's initial research on prostaglandin (PGE2). PGE2 is an endogenous substance of the human body that is central to various inflammatory processes. The project is aiming at the development of a medication which specifically targets PGE2 synthesis inhibition. Such selective inhibition could lead to a compound with the potential for fewer side effects than existing pain and inflammation medications, such as the NSAIDs.

"We are delighted to report this significant progress in our collaboration with Boehringer Ingelheim, a global player with expertise in the inflammatory pain area and an excellent partner for Orexo. By combining our skills and resources, we are convinced that new and better drugs will sooner be available, for millions of patients," says Dr Torbjörn Bjerke, President and Chief Executive Officer of Orexo."

"We remain impressed by the quality of Orexo's expertise in the area of arachidonic acid pathways", says Prof. Wolfgang Rettig, Corporate Senior Vice President Research at Boehringer Ingelheim. "The medical need in the area of pain and inflammation is considerable and this collaboration has the potential to address the patients' and physicians' need for a new treatment regarding safety and efficacy."