Positive top-line results from POZEN's PA32540 Phase 1 study against cardiovascular disease

POZEN Inc. (NASDAQ: POZN), a pharmaceutical company committed to transforming medicine that transforms lives, announced today positive top-line results of a Phase 1 study of PA32540, a novel coordinated-delivery tablet of enteric-coated (EC) aspirin (325 mg) and immediate-release (IR) omeprazole (40 mg). The data from the Co-Rx Study (pronounced "Co-Rex") suggest that PA32540 given in conjunction with clopidogrel, dosed at least 10 hours apart, resulted in significantly better inhibition of ADP-induced platelet aggregation (anti-clotting) when compared to a current standard of care (81 mg of EC aspirin, EC omeprazole 40 mg and clopidogrel). Additional data from this study are expected to be presented at an upcoming scientific meeting.

"The findings suggest that the dual antiplatelet regimen of clopidogrel plus PA32540, that contains IR omeprazole, results in an approximate 20% improvement in the anti-clotting effects compared to a current clinical standard of care dual antiplatelet regimen," said John G. Fort, M.D., Chief Medical Officer of POZEN and co-investigator for the study. "Although the clinical significance of these results is presently unknown, we continue to believe that PA32540 offers a promising potential option for the secondary prevention of heart attacks and strokes in cardiovascular patients who require aspirin therapy, but are at risk for gastric ulcers."

PA32540, an investigational coordinated-delivery tablet of immediate-release omeprazole, a proton pump inhibitor (PPI), layered around pH-sensitive aspirin, is being investigated for the secondary prevention of cardiovascular disease in patients at risk for aspirin-associated gastric ulcers. This investigational product is part of POZEN's pipeline of integrated aspirin therapies, called the PA product portfolio.

Source: POZEN Inc