Positive airway pressure reduces depressive symptoms in patients with OSA

Jun 12 2012

Patients seen at the Cleveland Clinic Sleep Disorders Center who used positive airway pressure (PAP) to treat their obstructive sleep apnea (OSA) had improvements in their depressive symptoms, even if they followed the prescribed PAP regimen only partly, a new study reports.

The study looked at 779 patients with OSA and asked them to fill out a standardized PHQ-9 form to assess depressive symptoms, which patients with OSA often have, researchers said. They were assessed again with the PHQ-9 following PAP treatment, and all showed improvement in PHQ-9 scores; however, patients using their PAP devices more than four hours per night had greater score improvements than those who were less adherent. Other factors that affected the improvements in PHQ-9 scores were whether the patient was sleepy and marital status.

"The score improvements remained significant even after taking into account whether a patient had a prior diagnosis of depression or was taking an anti-depressant," said Charles Bae, MD, principal investigator in the study. "The improvements were greatest in sleepy, adherent patients but even non-adherent patients had better PHQ-9 scores. Another interesting finding was that among patients treated with PAP, married patients had a greater decrease in PHQ-9 scores compared to single or divorced patients."

Source: American Academy of Sleep Medicine