Alendronate decreases BMD loss in prostate cancer

medwireNews: Weekly administration of oral biphosphonate alendronate could reduce loss of bone mineral density (BMD) in prostate cancer patients who start androgen-deprivation therapy (ADT), show study findings.

The 1-year trial, which was conducted across 30 urology sites in Canada, showed that the regimen not only prevented bone loss and increased bone mass, but it also decreased bone turnover.

Men initiating ADT are at risk for loss of BMD and osteoporotic fractures, yet the majority of men do not receive any treatment for this side effect, explain Laurence Klotz (Sunnybrook Health Sciences Centre, Toronto, Canada) and team. Calcium and vitamin D supplementation are recommended, although there is little support for this therapy in the setting of ADT.

The team conducted an intention-to-treat analysis of 167 patients initiating ADT therapy (leuprolide acetate 30 mg intramuscularly every 4 months), who were randomly allocated to receive either once-weekly oral alendronate 70 mg or placebo. All patients also took calcium 1 g and vitamin D 400 IU once daily.

As reported in European Urology, the mean spine BMD increased by 1.7% from baseline in the alendronate group, compared with a 1.9% decrease from baseline in the placebo group. Similarly, the mean total hip BMD increased by 0.7% in the alendronate group while it decreased by 1.6% in the placebo group.

The team also observed significantly greater improvements in markers for bone desorption as well as for bone formation and turnover.

The bone resorption marker, cross-linked N-telopeptide of type I collagen (Ntx), was decreased by a median of 3.5% in the alendronate group and increased by a median of 16.5% in the placebo group. Baseline urinary Ntx was also a significant predictor for loss of BMD.

Furthermore, bone-specific alkaline phosphatase, a marker of bone formation and turnover, was decreased by a median of 2.25% in the alendronate group and increased by a median of 3.12% in those who took placebo.

"Previous epidemiologic studies have suggested that high bone turnover is an independent risk factor for osteoporotic fractures," note Klotz and colleagues.

"Because loss of BMD in the ADT setting is associated with an increased fracture risk that is not mitigated by oral calcium and vitamin D supplementation, oral bisphosphonate therapy may have a role in men initiating androgen deprivation," concludes the team.

Licensed from medwireNews with permission from Springer Healthcare Ltd. ©Springer Healthcare Ltd. All rights reserved. Neither of these parties endorse or recommend any commercial products, services, or equipment.

Sally Robertson

Written by

Sally Robertson

Sally first developed an interest in medical communications when she took on the role of Journal Development Editor for BioMed Central (BMC), after having graduated with a degree in biomedical science from Greenwich University.

Citations

Please use one of the following formats to cite this article in your essay, paper or report:

  • APA

    Robertson, Sally. (2018, August 23). Alendronate decreases BMD loss in prostate cancer. News-Medical. Retrieved on December 25, 2024 from https://www.news-medical.net/news/20120919/Alendronate-decreases-BMD-loss-in-prostate-cancer.aspx.

  • MLA

    Robertson, Sally. "Alendronate decreases BMD loss in prostate cancer". News-Medical. 25 December 2024. <https://www.news-medical.net/news/20120919/Alendronate-decreases-BMD-loss-in-prostate-cancer.aspx>.

  • Chicago

    Robertson, Sally. "Alendronate decreases BMD loss in prostate cancer". News-Medical. https://www.news-medical.net/news/20120919/Alendronate-decreases-BMD-loss-in-prostate-cancer.aspx. (accessed December 25, 2024).

  • Harvard

    Robertson, Sally. 2018. Alendronate decreases BMD loss in prostate cancer. News-Medical, viewed 25 December 2024, https://www.news-medical.net/news/20120919/Alendronate-decreases-BMD-loss-in-prostate-cancer.aspx.

Comments

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
Post a new comment
Post

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.

You might also like...
Scientists create blood test to enhance cancer treatment effectiveness