Oct 21 2013
EntreMed, Inc. (NASDAQ: ENMD), a clinical-stage pharmaceutical company developing therapeutics for the treatment of a variety of cancers, announced today the presentation of preclinical data from a study to assess the role of p53 family tumor suppressors in mediating response to ENMD-2076 in triple-negative breast cancer (TNBC). The study was led by Dr. Jennifer R. Diamond of University of Colorado and the results were presented at the AACR-NCI-EORTC International Conference being held this week in Boston, Massachusetts.
Dr. Diamond commented, "The purpose of this study is to utilize TNBC cell line gene knockdown models to investigate further the role of p53 and p73 in mediating sensitivity to ENMD-2076. Data from the study demonstrate that ENMD-2076 exhibited robust anticancer activity in both p53 mutated and p53 wild type (WT) cell lines. The data also illustrate that both p53 and p73 mediate sensitivity to ENMD-2076 in p53 WT TNBC, while p73 is essential for induction of senescence following exposure to ENMD-2076, providing support on the development of predictive biomarkers of response to ENMD-2076 in p53 mutated TNBC currently underway."
Ken K. Ren, Ph.D, EntreMed's Chief Executive Officer, commented, "ENMD-2076 is currently in Phase 2 clinical trials in patients with TNBC and advanced/metastatic soft tissue sarcoma, and we expect to begin enrolling in a multi-center Phase 2 trial in ovarian clear cell carcinomas. We have also been conducting additional preclinical studies on the drug candidate primarily to support our clinical trials with better understanding of its mechanism of actions, predictive biomarkers, and scientific rationale for new clinical applications. Taken together, we believe they will shed additional light on more advanced clinical trials and enhance the value of ENMD-2076."
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