Promoting innate detoxification mechanisms could be efficient strategy to reduce cellular oxidative stress

Jun 21 2017

Promoting innate detoxification mechanisms in the body and discovering which supplements increase the efficacy of those biochemical pathways could be an efficient strategy to reduce the cellular oxidative stress and protect our health, according to an article published in the journal Food Chemistry, by the researchers Rafael Franco, from the Institute of Biomedicine of the University of Barcelona, and Eva Martínez Pinilla, from the Institute of Neurosciences of Asturias (INEUROPA) and the University of Oviedo.

According to the new study, which analyses scientific information on the metabolism and health under the perspective of chemical laws, antioxidant properties in the molecules of in vitro testings do not seem to be a good indicator of their in vivo activity. According to Professsor Rafael Franco, member of the Biomedical Research Networking Center on Neurodegenerative Diseases (CIBERNED), "living beings that live in an environment rich in Earth's atmosphere oxygen survive thanks to chemical reactions -mostly reduction-oxidation or REDOX reactions- which are not significantly affected by "antioxidant" molecules".

Oxidative stress and free radicals have been related to the origins of some chronic diseases and aging processes. "The main factor that contributes to increase the oxidative stress in cells unspecifically is age", says Rafael Franco. "Age affects negatively the efficiency of some detoxification mechanisms, and this would be the same mechanism that occurs in some diseases in which the production of the necessary compounds to maintain the rhythm of detoxification cycles is involved. The oxidative stress is caused by a deficiency in detoxification mechanisms and the simple consume of "antioxidants" cannot reverse this fact".

How to improve natural detoxification mechanisms?

The article, published in the journal Food Chemistry, analyses the main mechanisms to palliate the effects of cellular oxidative stress, developed by mammals over evolution. Out of these detoxification mechanisms, the most known one is the one of blood cells, based on glutathione -a tripeptide that would act as a powerful natural antioxidant- and the action of glucose-6-phosphate dehydrogenase (G6PDH), which creates another important antioxidant, NADPH, a basic co-enzyme in the cellular metabolism.

According to the experts, "living beings can properly manage oxidative stress thanks to selected mechanisms during evolution". Therefore, it would be necessary to better understand the detoxification mechanisms in the bodies, known as blood cells, instead of the brain: "Knowing this system better, we could act in two different ways: consuming precursors of compounds of innate detoxification systems, and also, making the detoxification mechanism more efficient. Regarding the blood cells, eating oxidant food such as beans -the opposite of consuming antioxidants- seems to be essential to improve the efficiency of innate detoxification mechanisms and increase the level of glutathione and glucose-6-phosphate dehydrogenase. Although it looks paradoxical, this is the pathway evolution took".

The healthy effects of the Mediterranean diet, with a nutrition pattern rich in antioxidant elements, could be explained due its huge capacity to strengthen the body's innate detoxification mechanisms, according to the authors. "Basically, the idea is that antioxidants are not necessary in an environment which is, and should be, highly oxidant: we should know detoxification mechanisms better and see which supplements can increase its efficiency".