Researchers develop a gentler and safer hair dye based on synthetic melanin

With the coronavirus pandemic temporarily shuttering hair salons, many clients are appreciating, and missing, the ability of hair dye to cover up grays or touch up roots.

However, frequent coloring, whether done at a salon or at home, can damage hair and might pose health risks from potentially cancer-causing dye components.

Now, researchers reporting in ACS Central Science have developed a process to dye hair with synthetic melanin under milder conditions than traditional hair dyes.

Melanin is a group of natural pigments that give hair and skin their varied colors. With aging, melanin disappears from hair fibers, leading to color loss and graying.

Most permanent hair dyes use ammonia, hydrogen peroxide, small-molecule dyes and other ingredients to penetrate the cuticle of the hair and deposit coloring. Along with being damaging to hair, these harsh substances could cause allergic reactions or other health problems in colorists and their clients.

Recently, scientists have explored using synthetic melanin to color human hair, but the process required relatively high concentrations of potentially toxic heavy metals, such as copper and iron, and strong oxidants.

Claudia Battistella, Nathan Gianneschi and colleagues at Northwestern University wanted to find a gentler, safer way to get long-lasting, natural-looking hair color with synthetic melanin.

The researchers tested different dyeing conditions for depositing synthetic melanin on hair, finding that they could substitute mild heat and a small amount of ammonium hydroxide for the heavy metals and strong oxidants used in prior methods.

They could produce darker hues by increasing the concentration of ammonium hydroxide, or red and gold shades by adding a small amount of hydrogen peroxide. Overall, the conditions were similar to or milder than those used for commercially available hair dyes.

And the natural-looking colors deposited on the hair surface, rather than penetrating the cuticle, which is less likely to cause damage. The colored layer persisted for at least 18 washes.