Second- or third-degree relatives could influence a person's risk of developing colorectal cancer

Reviewed by Emily Henderson, B.Sc.Sep 13 2021

Having second- or third-degree relatives with colorectal cancer increases a person's risk of developing the disease, according to the findings of a study led by researchers from the University at Buffalo and the University of Utah.

Early colonoscopy screening is often recommended for first-degree relatives of someone diagnosed with early-onset -; meaning before age 50 -; colorectal cancer, cases of which have been increasing significantly over the past few decades. But the study suggests that early screening may be beneficial for second- and third-degree relatives as well.

The study found that first-degree relatives of someone diagnosed with early-onset colorectal cancer are 6 times more likely to be diagnosed with colorectal cancer before age 50, while second-degree relatives are 3 times likelier and third-degree relatives 1.56 times likelier.

First-degree relatives include parents, children and siblings. Second-degree relatives include aunts, uncles, grandparents, grandchildren, nieces and nephews. First cousins, great-grandparents and great-grandchildren are examples of third-degree relatives.

The findings were published last month in the journal Cancer Epidemiology. Researchers from the University at Buffalo and University of Utah led the study, which reviewed more than 1,500 early-onset colon cancer cases in the Utah Cancer Registry, part of the Utah Population Data Base.

"Unique Utah resources, including a decades old National Cancer Institute statewide cancer registry and computerized genealogy data for the majority of the population, made this important collaboration possible," says Lisa Cannon-Albright, PhD, professor and leader of the genetic epidemiology program in the Department of Internal Medicine at the University of Utah School of Medicine. She is also a Huntsman Cancer Institute investigator.

Our study provides new insight into the magnitude of risk for more distant relatives of colorectal cancer cases, and in particular, for relatives of cases who were diagnosed before age 50. This work is important given the rising rates of early-onset colorectal cancer."

Heather Ochs-Balcom, PhD, first author, associate professor of epidemiology and environmental health in UB's School of Public Health and Health Professions

The study also found that individuals are at a 2.6-fold higher risk of colorectal cancer at any age if they have a first-degree relative with early-onset colon cancer. The risk is 1.96 and 1.3 times greater for second- and third-degree relatives, respectively. In addition, the risk for all degrees of relatives for early-onset colon cancer is higher than the risk for colon cancer at any age.

The findings suggest that early colonoscopy screening may be beneficial for second-degree relatives and possibly third-degree relatives, in addition to first-degree relatives of individuals diagnosed with colorectal cancer before age 50.

The researchers also point out that relatives may benefit from being more aware of their extended family history and sharing this information with their physician when making cancer screening decisions.