Viruses do not lead to new antibiotic resistance, can be our allies in defeating pathogenic bacteria

Reviewed by Emily Henderson, B.Sc.Dec 10 2021

Viruses may sometimes be our enemies, but they can also be our allies. When our medicines are no longer effective, viruses can be valuable partners in defeating pathogenic bacteria. But more importantly, viruses do not lead to new antibiotic resistance in bacteria. Such was the conclusion of an INRAE study, published on 25 October 2021 in the journal ISME Communications.

It is a fact that more and more bacteria are showing antibiotic resistance. Information campaigns have raised awareness among the general public that the main cause of antibiotic resistance is the high 'selection pressure' on bacteria due to massive and inappropriate use of antibiotics in both humans and animals.

But this is not the only explanation. A set of mechanisms in bacteria, known as horizontal gene transfers, are also involved. Bacteria are able to exchange DNA material with each other. Some of the DNA material that is exchanged does not contribute anything specific, while some could confer antibiotic resistance. Understanding the mechanisms by which the material carrying resistance genes is transferred could help scientists identify a new way to fight resistant bacteria.

Bacteriophages: a vector of resistance?

Over the last decade, a question has divided the scientific community: are bacteriophages, especially those used in phage therapy, capable of transferring antibiotic resistance genes to bacteria? Although a 2013 scientific article published in Nature found that bacteriophages could indeed do so, this answer has not put the matter to rest.

The controversy caught the attention of a team of INRAE researchers specialised in bacteriophages. The scientists conducted metagenomic research (analysis of the whole genome) on bacteriophages from pig fecal samples of 14 farms. Using in-depth computer analyses, the researchers finely characterised the DNA of all these bacteriophages and came to a clear conclusion: the bacteriophages studied do not possess a single antibiotic resistance gene. They cannot therefore supply resistance genes to bacteria.

This research sheds light on the issue of antibiotic resistance, a key public health concern. Bacteriophages continue to be used as allies in the fight against antibiotic-resistant bacteria through phage therapy. This practice, which is not yet widespread, uses bacteriophages on patients infected with bacteria that are resistant to all antibiotics. Bacteriophages attack and destroy the resistant bacteria, without the possibility of passing on resistance genes to other bacteria. The therapy offers hope in the fight against the growing phenomenon of antibiotic resistance.