Study addresses possible associations between chronic stress, mild cognitive impairment and Alzheimer's

Reviewed by Danielle Ellis, B.Sc.Oct 3 2023

Researchers from Karolinska Institutet have published a study in Alzheimer's Research & Therapy that addresses possible associations between chronic stress, mild cognitive impairment and Alzheimer's disease. The study shows how people aged between 18 and 65 with a previous diagnosis of chronic stress and depression were more likely than other people to be diagnosed with mild cognitive impairment or Alzheimer's disease.

Some 160,000 people have some form of dementia in Sweden, Alzheimer's disease being the most common, a figure that is rising with our life expectancy. At the same time, many new diagnostic methods and early-intervention therapies have been developed in recent years, which foregrounds the need to identify more risk factors for the disease.

Previous studies have demonstrated a possible association between chronic stress, depression and dementia. This present study now shows that people who have been diagnosed with chronic stress or depression are more likely to be diagnosed with Alzheimer's disease.

The study shows that the risk of Alzheimer's disease was more than twice as high in patients with chronic stress and in patients with depression as it was in patients without either condition; in patients with both chronic stress and depression it was up to four times as high.

The risk of developing cognitive impairment was elevated about as much. A patient is deemed to be suffering chronic stress when he or she has been under stress with no opportunity for recuperation for at least six months.

The risk is still very small and the causality is unknown. That said, the finding is important in that it enables us to improve preventative efforts and understand links with the other risk factors for dementia."

Axel C. Carlsson, study's last author, docent at the Department of Neurobiology, Care Sciences and Society, Karolinska Institutet

The study was conducted using Region Stockholm's administrative healthcare database, which contains all healthcare contacts compensated by the region. The researchers focused on patients between the ages of 18 and 65 and between 2012 and 2013. They identified 44,447 people with a diagnosis of chronic stress and/or depression and followed them for eight years to see how many of them were later diagnosed with mild cognitive impairment or Alzheimer's disease.

A comparison with all other 1,362,548 individuals in the age bracket showed that more people with chronic stress or depression had also been diagnosed with mild cognitive impairment or Alzheimer's disease.

"It's very uncommon for people in this age group to develop dementia, so we need to identify all possible risk factors for the disease," says Dr Carlsson. "We show here that the diagnosis is more common in people who have suffered chronic stress or depression, but more studies will be required if we're to demonstrate any causality there."

The researchers will now be continuing their work and developing questionnaires and cognitive tests to aid the early identification of people at risk of dementia.

The study was financed by Region Stockholm and conducted with the Academic Primary Care Centre (APC).