New insights into the role of cancer-associated fibroblasts in promoting lymphatic metastasis

Chinese Academy of SciencesAug 8 2024

Lymph node metastasis is a crucial factor in cancer progression, significantly affecting patient prognosis and treatment outcomes. The tumor microenvironment, particularly cancer-associated fibroblasts (CAFs), plays a vital role in this process. CAFs influence the metastatic landscape through interactions with other cells and secretion of signaling molecules. Based on these challenges, it is essential to conduct in-depth research to uncover the molecular mechanisms involving CAFs and develop targeted therapies that can inhibit lymphatic metastasis and improve cancer treatment strategies.

Researchers from Sun Yat-sen Memorial Hospital, publishing a study (DOI: 10.20892/j.issn.2095-3941.2024.0138) in Cancer Biology & Medicine on May 22, 2024, have reviewed the heterogeneity of CAFs and their roles in promoting lymphatic metastasis. This study provides a comprehensive analysis of how different CAF subsets interact with the tumor microenvironment, offering new strategies for targeted cancer therapies.

This study highlights the crucial role of CAFs in shaping the lymphatic metastatic landscape. Researchers reviewed various CAF subsets that interact with other stromal cells, secrete cytokines, and produce exosomes, all of which contribute to lymphatic invasion and metastasis. One significant finding is the role of PDGFRα⁺ITGA11⁺ CAFs in bladder cancer, which directly interact with lymphatic endothelial cells, enhancing lymphovascular invasion and metastasis. The study also explores the therapeutic potential of targeting specific CAF subsets, showing promising results in preclinical models. By inhibiting the interactions between CAFs and other cells, particularly through targeted antibodies, researchers demonstrated a reduction in lymphatic metastasis. These findings offer valuable insights into the complex mechanisms of CAF-mediated metastasis and suggest new avenues for developing targeted cancer therapies.

Our findings underscore the complexity and significance of CAF heterogeneity in cancer progression. By targeting specific CAF subsets, we can develop more effective therapeutic strategies to inhibit lymphatic metastasis and improve patient outcomes."

Dr. Changhao Chen, lead researcher

The insights from this study pave the way for developing novel cancer therapies that specifically target CAFs. By understanding the diverse roles of CAFs in tumor metastasis, researchers can design targeted treatments that potentially reduce the spread of cancer and enhance the efficacy of existing therapies. This approach could lead to improved prognoses and quality of life for cancer patients.