APOLLO Raman Microspectrometer for Pharmaceutical Monitoring

Pharmaceutical monitoring is an integral part of the production, testing and manufacturing process.  To this end, CRAIC Technologies, a company specializing in high-quality UV-visible-NIR microanalysis solutions, has developed several Raman microspectroscopy solutions to perform these tests easily, rapidly and precisely.

Raman Microspectrometer

With the easy-to-use Raman microspectrometer, samples take little or no time to prepare for analysis and the data obtained can be used to monitor gels, solids or even liquids as they go through production. With this data, users can be assured of an optimal and consistent manufacturing process.

Experimental Framework

Figure 1. APOLLO Raman microspectrometer

This paper reports on solids that were inspected as tablets. The tablets were cut in half to allow analysis of only the internal active ingredients and not the exterior coating. This was the only preparation that was required.

The APOLLO Raman microspectrometer (Figure 1) is specifically designed to determine the Raman scattering from a small amount of sample with high spatial resolution. A range of integration times were utilized and a minimum of 9 scans were averaged. The source of excitation was a 785nm laser and the spectral range of the measurements was 80 to 2100cm-1. Samples were quantified by placing them under the objective and turning on the Raman microspectrometer.

Results

An acetaminophen tablet was the first pharmaceutical to be examined. The tablet was cut in half and the centre was analyzed as the exterior did not contain any active ingredients. The integration time was 5 seconds and 2 scans were averaged (Figure 2).

Figure 2. Ramanspectrum acetaminophen

Aspirin was the next sample to be analyzed. The integration time and scans averaged were same as the acetaminophen tablet (Figure 3).

Figure 3. Ramanspectrum aspirin

The next pharmaceutical to be examined was the paracetemol sample. The active pharmaceutical ingredients can be clearly seen in Figure 4.

 

Figure 4. Ramanspectrumofa paracetemol

Conclusion

CRAIC’s APOLLO Raman microspectrometer can detect pharmaceutical components rapidly and easily while requiring only minimal sample preparation. Solid tablets can be examined on a microscopic scale, owing to the excellent sensitivity and resolution of the instrument. The APOLLO Raman microspectrometer is a valuable tool for any pharmaceutical quality assurance laboratory.

Acknowledgement

Produced from articles authored by Dr. Paul Martin, CRAIC Technologies.

About CRAIC Technologies

Since its inception, CRAIC has specialized in optical tools for the ultraviolet, visible, and near-infrared regions. Products include microspectrophotometers (also known as microspectrometers or microscope spectrometers) that is able to take spectra of samples smaller than a micron. CRAIC has also designed and built UV-visible-NIR range microscopes. Full spectral range fluorescence, transmission, and reflectance spectra and images can be acquired from any microscopic sample non-destructively and without contact with these tools. CRAIC manufactures both scientific grade systems in addition to specialized systems for industries such as semiconductor inspection and pharmaceutical metrology. CRAIC also makes NIST Traceable Standards, the only ones in the world specifically designed for microspectrophotometers, and specialized software packages.

CRAIC specializes in the following micro-analytical techniques:

  • UV-Visible-NIR microspectroscopy
  • UV-visible-NIR microscopy
  • Color microspectroscopy
  • Transmission microspectroscopy & microscopy
  • Reflectance microspectroscopy & microscopy
  • Fluorescence microspectroscopy & microscopy
  • Polarization microspectroscopy & microscopy
  • Raman microspectroscopy
  • Film thickness measurements
  • Spectral modeling

CRAIC has more experience designing, developing, manufacturing and installing microspectrophotometers than anyone. CRAIC is committed to maintaining the highest level excellence for its' products and service.


Sponsored Content Policy: News-Medical.net publishes articles and related content that may be derived from sources where we have existing commercial relationships, provided such content adds value to the core editorial ethos of News-Medical.Net which is to educate and inform site visitors interested in medical research, science, medical devices and treatments.

Last updated: Jul 19, 2024 at 5:36 AM

Citations

Please use one of the following formats to cite this article in your essay, paper or report:

  • APA

    CRAIC Technologies, Inc.. (2024, July 19). APOLLO Raman Microspectrometer for Pharmaceutical Monitoring. News-Medical. Retrieved on November 21, 2024 from https://www.news-medical.net/whitepaper/20140403/APOLLO-Raman-Microspectrometer-for-Pharmaceutical-Monitoring.aspx.

  • MLA

    CRAIC Technologies, Inc.. "APOLLO Raman Microspectrometer for Pharmaceutical Monitoring". News-Medical. 21 November 2024. <https://www.news-medical.net/whitepaper/20140403/APOLLO-Raman-Microspectrometer-for-Pharmaceutical-Monitoring.aspx>.

  • Chicago

    CRAIC Technologies, Inc.. "APOLLO Raman Microspectrometer for Pharmaceutical Monitoring". News-Medical. https://www.news-medical.net/whitepaper/20140403/APOLLO-Raman-Microspectrometer-for-Pharmaceutical-Monitoring.aspx. (accessed November 21, 2024).

  • Harvard

    CRAIC Technologies, Inc.. 2024. APOLLO Raman Microspectrometer for Pharmaceutical Monitoring. News-Medical, viewed 21 November 2024, https://www.news-medical.net/whitepaper/20140403/APOLLO-Raman-Microspectrometer-for-Pharmaceutical-Monitoring.aspx.

Other White Papers by this Supplier

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.