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Study reveals the role of lncRNAs in immune dysfunction during severe COVID-19

Scientific studies rarely focus on long non-coding RNA molecules (lncRNAs), even though they potentially regulate several diseases. The role of several lncRNAs in anti-viral inflammatory response regulation has recently been reported.

28 Apr 2021

Why do we lose our sense smell/taste with COVID?

The angiotensin-converting enzyme 2 (ACE2) enzyme attached to the membranes of cells is the entry point for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). They are abundantly found all over the body and most prominently in the lungs and nose.

28 Apr 2021

Researchers design "nanotraps" to capture and destroy SARS-CoV-2 viruses

Researchers at the Pritzker School of Molecular Engineering at the University of Chicago have designed a completely novel potential treatment for COVID-19: nanoparticles that capture SARS-CoV-2 viruses within the body and then use the body's own immune system to destroy it.

27 Apr 2021

New treatment reduces the severity of ARDS in influenza-infected mice

A new treatment is among the first known to reduce the severity of acute respiratory distress syndrome caused by the flu in animals, according to a new study.

27 Apr 2021

CU Cancer Center researchers receive PRCRP grant to investigate metastasis

Two members of the University of Colorado Cancer Center have received prestigious Idea Awards from the U.S. Department of Defense's Peer Reviewed Cancer Research Program.

27 Apr 2021

Some heart medications may facilitate SARS-CoV-2 infection through increasing ACE2 receptor levels

An interesting poster, just presented at the annual meeting of the American Society for Pharmacology and Experimental Therapeutics 2021, reports an association between the use of certain heart medications and the risk of COVID-19.

27 Apr 2021

Nucleocapsid-based vaccines may prevent SARS-CoV-2 dissemination to distal organs

A team of scientists recently investigated and compared the efficacy of spike-based and nucleocapsid-based COVID-19 vaccines in mice infected with SARS-CoV-2. Their findings reveal that nucleocapsid-based vaccines are effective in preventing SARS-CoV-2 infection in distal organs, such as the brain.

27 Apr 2021

Doctoral students recommend changing the protocols around use of tear gas on crowds

A new study by five doctoral students in neuroscience at the University of Minnesota Medical School calls attention to a lack of regulation and unknown long-term health effects of tear gas. Based on their research, the group recommends changing the protocols around the use of tear gas as a crowd control measure at both the local and national level.

27 Apr 2021

Study offers insight into how damage to airways of the lung develops into pre-cancer lesions

Lung carcinomas are the leading cause of cancer-related deaths in the United States and worldwide. Lung squamous cell carcinomas (non-small cell lung cancers that arise in the bronchi of the lungs and make up approximately 30 percent of all lung cancers) are poorly understood, particularly with respect to the cell type and signals that contribute to disease onset.

26 Apr 2021

Researchers identify natural molecule that blocks the binding of human antibodies to SARS-CoV-2

Researchers have found that a natural molecule can effectively block the binding of a subset of human antibodies to SARS-CoV-2. The discovery may help explain why some COVID-19 patients can become severely ill despite having high levels of antibodies against the virus.

23 Apr 2021

New potential target for treating metastasized oral malignant melanoma in dogs

Scientists have shown that the biological molecule PD-L1 is a potential target for the treatment of metastasized oral malignant melanoma in dogs.

23 Apr 2021

DNA vaccine candidate induces potent immunity, offers protective efficacy in non-human primate models

A synthetic DNA vaccine candidate for Middle East respiratory syndrome coronavirus (MERS-CoV) developed at The Wistar Institute induced potent immune responses and afforded protective efficacy in non-human primate (NHP) models when given intradermally in abbreviated, low-dose immunization regimen.

23 Apr 2021

COVID-19 survivors have increased risk of death for at least six months

As the COVID-19 pandemic has progressed, it has become clear that many survivors -; even those who had mild cases -; continue to manage a variety of health problems long after the initial infection should have resolved.

23 Apr 2021

FDA approves immunotherapy for treating patients with dMMR endometrial cancer

Today, the U.S. Food and Drug Administration granted accelerated approval to Jemperli (dostarlimab) for treating patients with recurrent or advanced endometrial cancer that has progressed on or following prior treatment with a platinum-containing chemotherapy and whose cancers have a specific genetic feature known as dMMR (which contain abnormalities that affect the proper repair of DNA inside the cell), as determined by an FDA-approved test.

22 Apr 2021

New Phase 3 trial of therapeutics begins enrolling severely ill hospitalized COVID-19 patients

A new Phase 3 trial to test the safety and efficacy of therapeutics for COVID-19 has begun enrolling patients hospitalized with life-threatening cases of COVID-19, including those with acute respiratory failure.

22 Apr 2021

Doctors scramble to understand long Covid, but causes and prognosis are elusive

One night in March 2020, Joy Wu felt like her heart was going to explode. She tried to get up and fell down. She didn't recognize friends' names in her list of phone contacts. Remembering how to dial 9-1-1 took "quite a bit of time," she recalled recently.

22 Apr 2021

Study casts doubt on promotion of 'Heat not Burn' products as less harmful alternative to cigarettes

The impact on lung cells of Heat not Burn products--a hybrid between traditional cigarettes and electronic vaping devices--may be no less harmful than that of conventional cigarettes, suggest the findings of a small comparative study, published online in the journal Thorax.

22 Apr 2021

Metabolic testing of COVID-19 patients through skin imprints

There is, therefore, a great need to understand how the illness can be diagnosed using more convenient and inexpensive methods. A new study posted to the medRxiv preprint server reveals the potential role of skin imprints to test for biomarkers that indicate a diagnosis of COVID-19 in a non-invasive way.

22 Apr 2021

Algorithm accurately identifies pulmonary arterial hypertension in patients with scleroderma

Screening for a sometimes fatal condition among patients with a rare autoimmune disease could soon - thanks to a computer algorithm - become even more accurate.

21 Apr 2021

Interfering RNA nanoparticles could be a potential COVID-19 therapy

Study shows lipid nanoparticle-based siRNA is potent in suppressing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the causative agent of coronavirus disease 2019 (COVID-19) – in cells as well as in mice models.

21 Apr 2021

Lungs News and Research

Study reveals the role of lncRNAs in immune dysfunction during severe COVID-19

Why do we lose our sense smell/taste with COVID?

Researchers design "nanotraps" to capture and destroy SARS-CoV-2 viruses

New treatment reduces the severity of ARDS in influenza-infected mice

CU Cancer Center researchers receive PRCRP grant to investigate metastasis

Some heart medications may facilitate SARS-CoV-2 infection through increasing ACE2 receptor levels

Nucleocapsid-based vaccines may prevent SARS-CoV-2 dissemination to distal organs

Doctoral students recommend changing the protocols around use of tear gas on crowds

Study offers insight into how damage to airways of the lung develops into pre-cancer lesions

Researchers identify natural molecule that blocks the binding of human antibodies to SARS-CoV-2

New potential target for treating metastasized oral malignant melanoma in dogs

DNA vaccine candidate induces potent immunity, offers protective efficacy in non-human primate models

COVID-19 survivors have increased risk of death for at least six months

FDA approves immunotherapy for treating patients with dMMR endometrial cancer

New Phase 3 trial of therapeutics begins enrolling severely ill hospitalized COVID-19 patients

Doctors scramble to understand long Covid, but causes and prognosis are elusive

Study casts doubt on promotion of 'Heat not Burn' products as less harmful alternative to cigarettes

Metabolic testing of COVID-19 patients through skin imprints

Algorithm accurately identifies pulmonary arterial hypertension in patients with scleroderma

Interfering RNA nanoparticles could be a potential COVID-19 therapy

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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