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New insights that advance the current model of protein motility and muscle contraction

Scientists from the Burnham Institute for Medical Research and the University of Vermont have captured the first 3-dimensional (3D) atomic-resolution images of the motor protein myosin V as it "walks" along other proteins, revealing new structural insights that advance the current model of protein motility and muscle contraction.

3 Oct 2005

Sharper picture than previously available of major depressive disorder

Findings from the largest survey ever mounted on the co-occurrence of psychiatric disorders among U.S. adults afford a sharper picture than previously available of major depressive disorder (MDD) in specific population subgroups and of MDD's relationship to alcohol use disorders (AUDs) and other mental health conditions.

3 Oct 2005

Scientists measure with unprecedented accuracy the strengths of hydrogen bonds in a protein

The scientists were then able to predict the function of different versions of the protein based on structural information, a novel outcome that was published recently in the Proceedings of the National Academy of Sciences.

3 Oct 2005

First direct clues about how the brain alters the state of consciousness during sleep

In the human brain, cells talk to one another through the routine exchange of electrical signals. But when people fall into a deep sleep, the higher regions of the brain - regions that during waking hours are a bustling grid of neural dialogue - apparently lose their ability to communicate effectively, causing consciousness to fade.

3 Oct 2005

Discovery of mechanism in the body that could lead to autoimmune diseases

Researchers at National Jewish Medical and Research Center have discovered a mechanism in the body that could lead to autoimmune diseases, such as lupus, rheumatoid arthritis, or diabetes.

3 Oct 2005

Lab-made version of a human protein opens a new research avenue to better understand rheumatoid arthritis

A lab-made version of a human protein alleviates symptoms of both acute and chronic arthritis in mice and could be the basis for a new arthritis drug for people, report scientists from the National Institute of Allergy and Infectious Disease (NIAID), part of the National Institutes of Health (NIH).

3 Oct 2005

Steroids significantly reduce heart damage in children with Kawasaki's disease

When added to standard treatment, steroids significantly reduce the odds of developing heart damage in children with Kawasaki's disease, according to a study in the October issue of Pediatrics. These findings address a gap in knowledge.

3 Oct 2005

Plant-derived compounds appear to block the activity of an enzyme that triggers inflammation in joints

The findings came to light while the researchers were studying the wildly different ways in which cells in human blood vessels and joints respond to pressure gradients generated from liquid moving along their surface, a force called shear stress.

3 Oct 2005

New genes tied to lifespan extension

Drastically reducing calorie intake, or caloric restriction, is known to extend the lifespan of species including yeast, worms and rodents. Previous research linked a gene called Sir2 with lifespan extension due to caloric restriction, but worms and yeast that lack Sir2 also live longer when put on a tough diet, showing that some other genes must be at work.

3 Oct 2005

Organosilicon compounds help improve lithium battery technology

With the help of new silicon-based compounds, scientists -- and patients -- are getting a significant new charge out of the tiny lithium batteries used in implantable devices to help treat nervous system and other disorders.

3 Oct 2005

First identification of the genetic basis of disease in a patient with a complex I assembly defect

Mitochondrial complex I deficiency is one of the most common defects in patients with mitochondrial disease. The deficiency results from a failure to assemble the enzyme properly, but the nature of the molecular chaperones that are necessary for this process in mammals have remained obscure.

3 Oct 2005

Microarray technology may help tailor breast cancer therapy

Microarray technology could be used to tailor therapy according to the individual, and prevent breast cancer patients from having to undergo painful unsuccessful therapies.

3 Oct 2005

Research may help create drugs to target the molecule-binding pathway, beneficial for treating arthritis and reducing inflammation

The first close-up look at a pro-inflammatory signaling molecule involved in immune response in mammals suggests that researchers "should rethink what they are doing" in creating drugs based on a fruit-fly model, scientists say.

3 Oct 2005

Concerta, a once-daily form of the drug methylphenidate, successfully controlled ADHD symptoms

A new study has found that an all-day, extended-release stimulant for treating attention-deficit hyperactivity disorder (ADHD) remains effective for up to two years without significant side effects.

3 Oct 2005

Development of aggressive forms of prostate cancer may be influenced by environmental effects that occur early in life

How heavy a man is at the time he is diagnosed with prostate cancer, as well as his history of weight gain, appear to play significant roles in how aggressive his cancer may become, say researchers at the University of Texas M. D. Anderson Cancer Center.

3 Oct 2005

Clinical trials of daily oral antiretroviral dosing as pre-exposure prophylaxis

Writing in the journal Science, an international team of researchers, clinicians and others explains that a promising, relatively new approach is for people not infected but at high risk to take drugs that might prevent them from contracting HIV. But debate over the particulars of the strategy has slowed progress.

3 Oct 2005

Research News and Research

New insights that advance the current model of protein motility and muscle contraction

Sharper picture than previously available of major depressive disorder

Scientists measure with unprecedented accuracy the strengths of hydrogen bonds in a protein

First direct clues about how the brain alters the state of consciousness during sleep

Discovery of mechanism in the body that could lead to autoimmune diseases

Lab-made version of a human protein opens a new research avenue to better understand rheumatoid arthritis

Steroids significantly reduce heart damage in children with Kawasaki's disease

Plant-derived compounds appear to block the activity of an enzyme that triggers inflammation in joints

New genes tied to lifespan extension

Organosilicon compounds help improve lithium battery technology

First identification of the genetic basis of disease in a patient with a complex I assembly defect

Microarray technology may help tailor breast cancer therapy

Research may help create drugs to target the molecule-binding pathway, beneficial for treating arthritis and reducing inflammation

Concerta, a once-daily form of the drug methylphenidate, successfully controlled ADHD symptoms

Development of aggressive forms of prostate cancer may be influenced by environmental effects that occur early in life

Clinical trials of daily oral antiretroviral dosing as pre-exposure prophylaxis

MRI may better enable physicians to plan care for infants with heart defects

Attitudes of a peer group are more influential than a group that is not as closely allied

What works in preventing and reducing juvenile delinquency?

Grant for private, secure, electronic medical records search system

eBook: Advancing neurodegenerative research with iPSC-derived microglia models eBook

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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