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DNA, or deoxyribonucleic acid, is the hereditary material in humans and almost all other organisms. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).

Breakthrough in lupus research

A major breakthrough in lupus research - one that may fundamentally change thinking on how the disease affects behavior and cognition - was reported in the January 17, 2006 Proceedings of the National Academy of Sciences (PNAS).

25 Jan 2006

Researchers use yogurt to fight AIDS

Researchers have come up with a novel delivery system for anti-AIDS drugs: milk-curdling bacteria used to make yogurt and cheese.

25 Jan 2006

Faster method for detecting disease-causing mutations developed by Pitt researchers

University of Pittsburgh researcher Alexander Star and colleagues at a California-based company, Nanomix, Inc., have developed devices made of carbon nanotubes that can find mutations in genes causing hereditary diseases, they report in the Jan. 16 issue of the journal Proceedings of the National Academy of Science.

24 Jan 2006

Human body has a unique immune system response to foreign DNA

The human body has a unique immune system response to foreign DNA, suggesting that DNA viruses and RNA viruses are detected by different mechanisms, Yale School of Medicine researchers report this week in Immunity.

23 Jan 2006

FDA fast track status for Alfimeprase

Nuvelo Inc. today announced that it has been granted fast track designation by the U.S. Food and Drug Administration (FDA) for its lead product candidate, alfimeprase, for the treatment of acute peripheral arterial occlusion (PAO), or "leg attack."

23 Jan 2006

New real-time test for Chlamydia and Gonorrhea

Abbott today announced that a highly sensitive new test for the simultaneous detection of the sexually transmitted pathogens Chlamydia trachomatis (CT) and Neissera gonorrhoeae (NG) has received CE Mark certification, allowing it to be marketed in the European Union.

23 Jan 2006

Morphotek issued patent covering the use of chemical inhibitors of mismatch repair

Morphotek Inc. announced today the issuance of United States Patent 6,982,169 covering the use of chemical inhibitors to enhance evolution of target host cell genomes by reversibly regulating mismatch repair (MMR) in vivo.

23 Jan 2006

Protein amplifies DNA injury signals - cues genetic repair mechanism to prevent tumors

A Mayo Clinic-led research collaboration has discovered that the protein MDC1 amplifies weak DNA injury signals so genetic repair can begin.

23 Jan 2006

Ataxia gene identified

Researchers at the University of Minnesota Medical School have discovered the gene responsible for a type of ataxia, an incurable degenerative brain disease affecting movement and coordination.

23 Jan 2006

TCF21 gene shown to be a tumor suppressor

Researchers have identified a new and unusual tumor suppressor gene that may be important in cancers of the lung and head and neck. The study shows that restoring the inactivated gene can slow the growth of tumor cells.

18 Jan 2006

Retinal degeneration - researchers advance understanding

Researchers have labored for decades to understand blindness-inducing neurodegenerative diseases such as age-related macular degeneration (AMD) and retinitis pigmentosa (RP).

18 Jan 2006

Cost-effectiveness analysis of HPV testing

A new study has found that using human papillomavirus (HPV) DNA testing to determine who should receive a cervical examination called colposcopy is a cost-effective management strategy for women with equivocal Pap test results known as ASCUS (atypical squamous cells of undetermined significance).

18 Jan 2006

Variation in IGF1 gene may play a role in prostate cancer risk

Two variations in the gene for insulin-like growth factor I (IGF-1) are linked to an increased risk of prostate cancer, according to research performed by scientists from the Keck School of Medicine of the University of Southern California, the Broad Institute of Harvard and MIT, and the University of Hawaii.

18 Jan 2006

Missing protein C/EBPb may be cause of infertility

The absence of a key protein may lead to infertility. Researchers at the University of Illinois at Urbana-Champaign report that experiments involving mice -- to be detailed in the Proceedings of the National Academy of Sciences -- indicate that the transcription factor protein C/EBPb must be present in the uterus for pregnancy to occur.

18 Jan 2006

Genetic cause of autism

The researchers at the U School of Medicine made the finding by tracing variations in the DNA of an extended Utah family that has a high occurrence of the disorder and whose members are descended from one couple.

18 Jan 2006

Tissue-specific RNAi reveals that WT1 expression in nurse cells controls germ cell survival and spermatogenesis

Researchers at The University of Texas M. D. Anderson Cancer Center say they have jumped a significant hurdle in the use of RNA interference (RNAi), believed by many to be the ultimate tool to both decode the function of individual genes in the human genome and to treat disease.

16 Jan 2006

Genome-wide prediction of mammalian enhancers for control of gene expression

Molecular biologists, developmental biologists and computer scientists at the Universtity of Helsinki, Finland, came together to advance towards cracking the code for how gene expression is controlled. The results of this work are published in Cell, in January 2006.

16 Jan 2006

Physiogenomic resources for rat models of heart, lung and blood disorders

Every year, heart disease claims an estimated 7 million lives, according to the World Health Organization. Scientists have struggled to pinpoint the precise genes behind this complex disease. Now, however, they have a new research ally: the designer rat.

16 Jan 2006

Genetic fingerprint unmasks microbial vandals

For the first time DNA analysis can identify paper-degrading microorganisms.

16 Jan 2006

Diabetes gene found in 40% of population

Researchers in Iceland say they have identified a single genetic change which could predispose close to 40 percent of the population to type-2 diabetes.

16 Jan 2006