Disease Modeling News and Research

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Research on iPS cells can imply potential cell therapy for X-linked disorders

Female induced pluripotent stem (iPS) cells, reprogrammed from human skin cells into cells that have the embryonic-like potential to become any cell in the body, retain an inactive X chromosome, stem cell researchers at UCLA have found.

4 Sep 2010

Research on motor neuron subtype may provide useful therapy for neuron diseases

Scientists have devised a method for coaxing mouse embryonic stem cells into forming a highly specific motor neuron subtype. The research, published by Cell Press in the September 3rd issue of the journal Cell Stem Cell, provides new insight into motor neuron differentiation and may prove useful for devising and testing future therapies for motor neuron diseases.

3 Sep 2010

Researchers use zebrafish as model to analyze function of every known mutation in BBS

A research team led by scientists from the Duke University Medical Center has developed a way to simultaneously look at the effects of 125 mutations occurring on 14 different genes. They used zebrafish as a model to analyze the function of every known mutation in an inherited syndrome called BBS, Bardet-Biedl Syndrome.

25 May 2010

Electronic primary care records can help identify untreated patients at high risk of cardiovascular disease

Using routine data from electronic patient records to select individuals at high risk of developing heart disease, rather than screening all adults aged between 40 and 74 years of age, is just as effective at saving lives but will be cheaper to run, according to research published on bmj.com today.

26 Apr 2010

StemCells granted UK patent covering true rat stem cells and genetically engineered rats

StemCells, Inc. announced today that the United Kingdom (UK) Intellectual Property Office has granted patent number GB2451523 with broad claims covering true (germline competent) rat stem cells and genetically engineered rats derived from these cells. The patented technology is expected to have significant utility to academic and pharmaceutical industry researchers by enabling them to create novel rat models for the study of human diseases. Both mice and rats are used by scientists to model various human diseases.

18 Mar 2010

Scientists create Pandemic Influenza Planning Tool to model the spread of pandemic influenza

As communities brace for rising wintertime influenza cases, scientists are developing a mathematical and visual analytic toolkit to help health officials quickly analyze pandemics and craft better response strategies.

15 Dec 2009

Touch of MIDAS to prepare the world for contagious outbreaks

To help the nation-and the world-understand and prepare for contagious outbreaks, the National Institutes of Health's Models of Infectious Disease Agent Study (MIDAS) adds new research expertise to increase its capacity to simulate disease spread, evaluate different intervention strategies and help inform public health officials and policymakers.

4 Sep 2009

Intervention strategies to curb spread of pandemic flu

Mathematicians, biostaticians and public health officials from Canada, Mexico and the United States will gather at Arizona State University this week to focus on understanding, possibly mitigating the spread of the H1N1 flu virus. They are planning to take up the challenge of proposing science-based strategies that can slow the spread of pandemic flu.

24 Jun 2009

Phylonix granted broad U.S. patent for assessing cardiac functions in Zebrafish

Phylonix Pharmaceuticals announced, at the Society of Toxicology Annual Meeting in Baltimore, that the U.S. Patent and Trademark Office has issued the company a broad patent for assessing the toxicity of pharmaceutical test agents on cardiovascular functions in zebrafish.

15 Mar 2009

Motor neurons derived from human embryonic stem cells provide insight into ALS

Two new research studies use motor neurons derived from human embryonic stem (hES) cells to demonstrate that multiple toxic pathways contribute to the devastating degeneration associated with Amyotrophic Lateral Sclerosis (ALS) and that protective therapeutics will need to oppose the disease on multiple fronts.

3 Dec 2008

A simulated pandemic influenza outbreak in Chicago

By using computer simulations and modeling, an international group of researchers including scientists from the Virginia Bioinformatics Institute (VBI) at Virginia Tech's Network Dynamics and Simulation Science Laboratory (NDSSL) have determined how a pandemic influenza outbreak might travel through a city similar in size to Chicago, Ill.

11 Mar 2008

Pandemic influenza could be mitigated if measures were implemented quickly

An outbreak of pandemic influenza in the U.S. could be mitigated with prompt implementation of social-distancing measures combined with antiviral treatment and prophylaxis until a vaccine is available, according to new findings published in the online Early Edition of PNAS.

10 Mar 2008

FDA and Pharsight continue to collaborate under CRADA

Pharsight Corporation has provided an update on its Cooperative Research and Development Agreement (CRADA) with the Food and Drug Administration's (FDA) Center for Drug Evaluation and Research (CDER).

12 Dec 2007

Limited human-to-human spread of Avian-flu virus in Indonesia in 2006 confirmed

In the first systematic, statistical analysis of its kind, infectious-disease-modeling experts at Fred Hutchinson Cancer Research Center confirm that the avian influenza A (H5N1) virus in 2006 spread between a small number of people within a family in Indonesia.

28 Aug 2007

NIAID program aims to model immune responses and key infectious diseases

A new program at the National Institute of Allergy and Infectious Diseases (NIAID) aims to better understand the complex biochemical networks that regulate the interactions between infectious organisms and the human or animal cells they infect.

12 Jul 2006