Drug Discovery News and Research

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The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

Authors review current progress in developing transgenic pig models for human diseases

Genetically engineered pigs, minipigs, and microminipigs are valuable tools for biomedical research, as their lifespan, anatomy, physiology, genetic make-up, and disease mechanisms are more similar to humans than the rodent models typically used in drug discovery research.

24 Nov 2014

Five USF faculty members named AAAS Fellow

Five faculty members from the University of South Florida in Tampa have been named Fellows of the American Association for the Advancement of Science. Election as an AAAS Fellow is an honor bestowed upon AAAS members by their peers.

24 Nov 2014

New E-capper from Porvair Sciences

The new E-capper from Porvair Sciences produces top quality seals and minimises the risk of repetitive strain injuries (RSI) in operators tasked with sealing deep well microplates or storage tube racks with re-useable cap mats.

From Porvair Sciences Limited 19 Nov 2014

New study shows that brain’s ability to manage stress depends on brain protein

The brain's ability to effectively deal with stress or to lack that ability and be more susceptible to depression, depends on a single protein type in each person's brain, according to a study conducted at the Icahn School of Medicine at Mount Sinai and published November 12 in the journal Nature.

14 Nov 2014

Isis Pharmaceuticals, AstraZeneca partner to develop new delivery methods for antisense oligonucleotides

AstraZeneca and Isis Pharmaceuticals Inc. today announced a strategic alliance to discover and develop novel delivery methods for antisense oligonucleotides.

14 Nov 2014

MicroMatrices, Advanced Cell Diagnostics sign preferred partnership agreement

MicroMatrices, a service provider specialised in high resolution cell type-specific analysis to characterise toxicological responses in different cell types in tissue, today announced a preferred partnership agreement with Advanced Cell Diagnostics, Inc., a leader in the field of molecular pathology and developer of cell and tissue-based analysis tools.

From Advanced Cell Diagnostics 11 Nov 2014

U of T, Chematria and IBM partner to find new treatments for Ebola virus

The University of Toronto, Chematria and IBM are combining forces in a quest to find new treatments for the Ebola virus.

11 Nov 2014

Researchers develop new test to identify drugs that could work against Lyme disease

Researchers from the Johns Hopkins Bloomberg School of Public Health have developed a test they say will allow them to test thousands of FDA-approved drugs to see if they will work against the bacteria that causes tick-borne Lyme disease.

4 Nov 2014

Inventiva’s IVA337 receives EMA COMP positive opinion on orphan drug designation for SSc treatment

Inventiva, a drug discovery company that focuses on therapeutic approaches involving transcription factors and epigenetic targets, today announces that the Committee for Orphan Medicinal Products (COMP) at the European Medicines Agency (EMA) has given a positive opinion on the designation of IVA337 as an orphan medicinal product.

4 Nov 2014

Astellas, Dana-Farber to develop K-Ras inhibitors for treatment of lung, pancreatic cancers

Dana-Farber Cancer Institute (Dana-Farber) and Astellas Pharma Inc. today announced a three-year collaboration to research and develop small molecule inhibitors of oncogenic K-Ras for the treatment of cancer, including lung cancer.

4 Nov 2014

CytRx provides overview of clinical development programs, reports 2014 Q3 financial results

CytRx Corporation (CYTR), a biopharmaceutical research and development company specializing in oncology, today reported financial results for the three months ended September 30, 2014, and also provided an overview of recent accomplishments by and upcoming milestones for its clinical development programs.

4 Nov 2014

Advanced Cell Diagnostics names Aquila-Histoplex as the first accredited RNAscope® Certified Service Provider in Europe

Aquila-Histoplex, a contract research organisation specialised in histological and multiplex staining technologies, was today announced as the first accredited RNAscope® Certified Service Provider in Europe by Advanced Cell Diagnostics, Inc. (ACD), a technology and market leader in the field of molecular pathology and developer of cell and tissue-based analysis tools.

From Advanced Cell Diagnostics 4 Nov 2014

Epicure project: an interview with Frédéric Cren

Epicure is a project led by Inventiva and Institut Curie that aims to deliver pre-clinical candidates on two novel epigenetic targets that have been selected due to their potential to activate immune responses against cancer cells. In addition one of these two targets has potential in respiratory indications such as asthma or COPD.

3 Nov 2014

Insilico Medicine, CCARL and Plantbiosis partner to advance research on aging

Through this unique partnership, the Baltimore-based Insilico Medicine and Lethbridge-based CCARL will provide expertise in aging research and build on the personalized medicine and drug discovery platforms OncoFinder and GeroScope to develop new systems for age-related diseases.

31 Oct 2014

New international consortium to advance GPCR research for drug development

The generation of high-resolution pictures of hundreds of medically important proteins known as G-protein coupled receptors (GPCRs) will be the goal of an ambitious new international partnership. Called the GPCR Consortium, this non-profit initiative brings together major pharmaceutical companies and leading research institutes from three continents to advance GPCR research for drug development.

29 Oct 2014

GE Healthcare launches startup campus Health Innovation Village to help entrepreneurs speed up health tech solutions

Today GE Healthcare officially opens Health Innovation Village, its first health tech startup campus, at its Finnish headquarters with the Minister of Economic Affairs in Finland, Jan Vapaavuori and the Mayor of Helsinki, Jussi Pajunen.

29 Oct 2014

BioTek awarded US Patent for automated ultrasonic blockage detection and cleaning in microplate washers

BioTek has been awarded U.S. Patent 8,858,718, covering the use of ultrasonic devices to check for clogged manifold tubes and to clean the manifold tubes of a microplate washer automatically. The two features are known as Verify™ and Ultrasonic Advantage™ and are available in BioTek’s 405 family of microplate washers.

28 Oct 2014

Pulmocide uses INTEGRA's VIAFLO Assist pipetting assistant to improve screening of novel compounds

INTEGRA reports on how respiratory drug discovery and development specialists - Pulmocide Ltd. (London, UK) are using a VIAFLO Assist pipetting assistant to enhance the productivity and reproducibility of their screening of novel compounds in a range of biological assays.

From INTEGRA Biosciences 28 Oct 2014

Calchan, Galapagos partner to discover and develop novel target for osteoarthritic pain

Calchan Holdings Limited, a UK company focused on the development of novel medicines based on calcium ion channel modulators, and Galapagos NV, a clinical stage biotech company focused on developing novel mode of action medicines, today announce that they have entered into a research collaboration in the area of osteoarthritis pain.

27 Oct 2014

Researchers identify compounds that could lead to discovery of new drugs for African sleeping sickness

In early drug discovery, you need a starting point, says Northeastern University associate professor of chemistry and chemical biology Michael Pollastri.

27 Oct 2014

Drug Discovery News and Research

Further Reading

Authors review current progress in developing transgenic pig models for human diseases

Five USF faculty members named AAAS Fellow

New E-capper from Porvair Sciences

New study shows that brain’s ability to manage stress depends on brain protein

Isis Pharmaceuticals, AstraZeneca partner to develop new delivery methods for antisense oligonucleotides

MicroMatrices, Advanced Cell Diagnostics sign preferred partnership agreement

U of T, Chematria and IBM partner to find new treatments for Ebola virus

Researchers develop new test to identify drugs that could work against Lyme disease

Inventiva’s IVA337 receives EMA COMP positive opinion on orphan drug designation for SSc treatment

Astellas, Dana-Farber to develop K-Ras inhibitors for treatment of lung, pancreatic cancers

CytRx provides overview of clinical development programs, reports 2014 Q3 financial results

Advanced Cell Diagnostics names Aquila-Histoplex as the first accredited RNAscope® Certified Service Provider in Europe

Epicure project: an interview with Frédéric Cren

Insilico Medicine, CCARL and Plantbiosis partner to advance research on aging

New international consortium to advance GPCR research for drug development

GE Healthcare launches startup campus Health Innovation Village to help entrepreneurs speed up health tech solutions

BioTek awarded US Patent for automated ultrasonic blockage detection and cleaning in microplate washers

Pulmocide uses INTEGRA's VIAFLO Assist pipetting assistant to improve screening of novel compounds

Calchan, Galapagos partner to discover and develop novel target for osteoarthritic pain

Researchers identify compounds that could lead to discovery of new drugs for African sleeping sickness

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