Immune System News and Research

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Lower risk of MIS-C during Omicron wave

Researchers estimate the risk of multisystem inflammatory syndrome in children (MIS-C) in Denmark.

9 Aug 2022

Research projects the future mortality burden due to hot nights

Excessively hot nights caused by climate change are predicted to increase the mortality rate around the world by up to 60% by the end of the century, according to a new international study that features research from the UNC Gillings School of Global Public Health.

9 Aug 2022

Researchers synthesize a small molecule that can be used to treat a range of cancers

Researchers at Tel Aviv University and the University of Lisbon have jointly identified and synthesized a small molecule that could be a more accessible and effective alternative to an antibody that is successfully used to treat a range of cancers.

8 Aug 2022

Powerful injectable gel provides hope for preventing glioblastoma relapse

Like the hardiest weed, glioblastoma almost always springs back -; usually within months after a patient's initial brain tumor is surgically removed.

8 Aug 2022

Researchers create a physical wiring diagram of the human immune system

In a new study, researchers systematically mapped the surface proteins on human leukocytes to examine interactions between their cell-surface proteomes and develop a physical wiring diagram encapsulating the diversity of surface protein architectures found across all major subsets of leukocytes.

8 Aug 2022

Implantable mechanotherapeutic drug delivery platform helps overcome host immune response

Implantable devices that release insulin into the body hold promise as an alternative way to treat diabetes without insulin injections or cannula insertions. However, one obstacle that has prevented their use so far is that the immune system attacks them after implantation, forming a thick layer of scar tissue that blocks insulin release.

8 Aug 2022

Terminally exhausted T cells may remain competent for transcription, researchers say

During a battle with cancer, T cells can become exhausted and are no longer able to function properly. The early phase of exhaustion can sometimes be reversed with immunotherapy drugs, but once T cells become too exhausted, it had been thought that this state was irreversible. However, new insights from University of Pittsburgh and UPMC researchers suggest that even the most fatigued T cells can be revived.

8 Aug 2022

BCG vaccine produces a "trained immunity response" which lasts more than a year

The immune boosting benefits of a tuberculosis vaccine can be seen in infants more than one year after vaccination, according to a new study.

8 Aug 2022

Higher suPAR levels linked with increased risk of blood clot formation

Blood clots are thought to occur in as many as a third of patients hospitalized with COVID-19. In many cases these clots can be deadly, such as pulmonary embolisms-;blood clots that travel to the lungs. In fact, in nearly one third of patients with COVID-19, these clots led to death.

4 Aug 2022

Mice study reveals hepatic consequences of exposure to endocrine disrupting chemical mixtures

We are increasingly being exposed to endocrine-disrupting chemicals (EDCs) that interfere with the normal functioning of our hormones. Bisphenol A (BPA) and phthalates, which are widely used in consumer products including plastics, aluminum cans, pharmaceuticals, and cosmetics, are well-known EDCs.

4 Aug 2022

Queen’s researchers receive grant from Breast Cancer Now to search for new treatments

Researchers at Queen's University Belfast have received funding from Breast Cancer Now to search for new treatments inspired by COVID-19 vaccine innovation.

3 Aug 2022

Genetic signatures may help predict immunotherapy response in patients with bladder cancer

Investigators from Cedars-Sinai Cancer have identified genetic signatures that could predict whether tumors in patients with bladder and other cancers will respond to immunotherapy.

3 Aug 2022

UVA researchers receive $15 million from LeDucq Foundation to advance understanding of atherosclerosis

The Boston-based LeDucq Foundation has awarded $15 million to researchers at UVA Health and their collaborators to advance our understanding of atherosclerosis, or hardening of the arteries, and find better ways to treat it.

3 Aug 2022

Turning to Organ-on-a-Chip Studies for the Future of Drug Discovery

In this interview, we speak to Tom Kostrzewski, VP of Science and Technology at CN Bio, about their organ-on-a-chip product and the future of drug discovery.

From CN-Bio 3 Aug 2022

Research describes how the thymus teaches T cells to recognize friendly proteins

T cells are a special class of white blood cells that patrol the body and attack infected or foreign tissue. They learn to distinguish friendly proteins from dangerous ones in an organ called the thymus.

2 Aug 2022

ADAR1 mutation sets off biochemical pathways that produce an organ-damaging autoimmune response

A new study shows how mutation of the ADAR1 gene sets off biochemical pathways that produce an autoimmune response that harms the developing brain and other areas of the body.

2 Aug 2022

Shear-thinning biomaterial-based minimally invasive strategy for delivery of targeted immunotherapy

Researchers at the Terasaki Institute for Biomedical Innovation (TIBI) have developed and optimized a minimally invasive method for more targeted, efficient, and sustained delivery of immunotherapeutic treatments for cancer.

2 Aug 2022

LJI acquires Carterra LSA instrument to enhance antibody screening and characterization efforts

Carterra, Inc., the world leader in innovative technologies enabling high-throughput biology, and La Jolla Institute for Immunology, a globally recognized non-profit research organization dedicated to understanding the power of the immune system to promote human health, announced today that LJI has acquired a Carterra LSA instrument to enhance its antibody screening and characterization work.

2 Aug 2022

Study aims to ascertain how COVID-19 and vitamin D misinformation was presented on YouTube

JMIR Publications recently published "COVID-19 and Vitamin D Misinformation on YouTube: Content Analysis" in JMIR Infodemiology, which reported that although social media platforms, such as YouTube, can be an inexpensive and effective method of sharing accurate health information, inaccurate and misleading information shared on YouTube can be dangerous for viewers.

2 Aug 2022

Pediatric adjuvant formulation offers protection against RSV in newborns

Respiratory syncytial virus (RSV) is the leading global cause of death in children under age 5 and lacks an effective vaccine. In a study from the Precision Vaccines Program at Boston Children's Hospital, a new vaccine formulation protected newborn mice against infection and evoked strong responses in immune cells from human newborns in the laboratory. Results were reported August 2 in Nature Communications.

2 Aug 2022

Immune System News and Research

Lower risk of MIS-C during Omicron wave

Research projects the future mortality burden due to hot nights

Researchers synthesize a small molecule that can be used to treat a range of cancers

Powerful injectable gel provides hope for preventing glioblastoma relapse

Researchers create a physical wiring diagram of the human immune system

Implantable mechanotherapeutic drug delivery platform helps overcome host immune response

Terminally exhausted T cells may remain competent for transcription, researchers say

BCG vaccine produces a "trained immunity response" which lasts more than a year

Higher suPAR levels linked with increased risk of blood clot formation

Mice study reveals hepatic consequences of exposure to endocrine disrupting chemical mixtures

Queen’s researchers receive grant from Breast Cancer Now to search for new treatments

Genetic signatures may help predict immunotherapy response in patients with bladder cancer

UVA researchers receive $15 million from LeDucq Foundation to advance understanding of atherosclerosis

Turning to Organ-on-a-Chip Studies for the Future of Drug Discovery

Research describes how the thymus teaches T cells to recognize friendly proteins

ADAR1 mutation sets off biochemical pathways that produce an organ-damaging autoimmune response

Shear-thinning biomaterial-based minimally invasive strategy for delivery of targeted immunotherapy

LJI acquires Carterra LSA instrument to enhance antibody screening and characterization efforts

Study aims to ascertain how COVID-19 and vitamin D misinformation was presented on YouTube

Pediatric adjuvant formulation offers protection against RSV in newborns

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