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Transplant drug rapamycin may reduce nerve damage, neuropathic pain after spinal cord injury

New research in mice indicates that a drug commonly used to suppress the immune system in recipients of organ transplants may also reduce tissue damage and neuropathic pain after spinal cord injury. The findings are published in the Journal of Orthopaedic Research.

8 Jul 2016

HHV-6A human herpesvirus infects uterus lining of women with unexplained infertility

A new study has found that the little-known member of the human herpesvirus family called HHV-6A infects the lining of the uterus in 43% of women with unexplained infertility but cannot be found in uterine lining of fertile women. The study was conducted by investigators at the University of Ferrara, Italy.

7 Jul 2016

Diabetes drug metformin could help reduce toxic acid levels linked to MSUD

Maple Syrup Urine Disease (MSUD) is a rare inherited metabolic disorder involving the dysfunction of an enzyme which breaks down three essential amino acids: leucine, isoleucine and valine.

6 Jul 2016

Emergency physicians encourage safe fireworks practices

Fireworks sales will be blazing across the country from now through the Fourth of July. As retailers begin their promotions, the Pennsylvania Academy of Ophthalmology, the Pennsylvania College of Emergency Physicians, and the Pennsylvania Medical Society join the American Academy of Ophthalmology in shining light on the explosive fact: fireworks injuries cause approximately 10,000 visits to the emergency room each year, according to the data from the U.S. Consumer Product Safety Commission.

4 Jul 2016

New strategy treats fatal autoimmune disease without outward off-target effects

In a study with potentially major implications for the future treatment of autoimmunity and related conditions, scientists from the Perelman School of Medicine at the University of Pennsylvania have found a way to remove the subset of antibody-making cells that cause an autoimmune disease, without harming the rest of the immune system.

4 Jul 2016

Surgeons outline complete face transplant procedure in facial burn patients

Last year, the most extensive clinical face transplant to date was successfully carried out at NYU Langone Medical Center.

30 Jun 2016

Study highlights role of CMV in patients with leukemia after bone marrow transplantation

Recent studies on a small number of patients with leukemia treated with bone marrow transplantation have suggested that the presence of the common cytomegalovirus (CMV) in patients or their donors may protect against relapse or even death after the transplant.

29 Jun 2016

LIF-treated muscle stem cells show promise in treatment of muscular dystrophy

Satellite cells are stem cells found in skeletal muscles. While transplantation of such muscle stem cells can be a potent therapy for degenerative muscle diseases such as Duchenne muscular dystrophy, these cells tend to lose their transplantation efficiency when cultured in vitro.

28 Jun 2016

Elevated troponin I should not rule out donor hearts

Donor cardiac troponin I level is not associated with intermediate-term mortality, cardiac allograft vasculopathy or primary graft failure in patients receiving heart transplants, US researchers report.

28 Jun 2016

Virtual tissue technology helps identify new drug target to combat polycystic kidney disease

Using virtual tissue technology, researchers at Indiana University have identified a potential new drug target in the fight against polycystic kidney disease, an illness with no effective FDA-approved treatment that affects 200,000 people per year in the United States.

28 Jun 2016

Researchers receive grant to improve quality of donor limb, tissue for transplant

A Case Western Reserve University School of Medicine faculty member has received $998,500 from the U.S. Department of Defense to develop a new approach to improve the quality and quantity of limbs and tissues obtained from brain dead organ donors.

27 Jun 2016

Eye donations: what stops people? An interview with Rory Passmore

Despite a shortage of corneas for transplant purposes, our new research reveals that eyes are the one body part we are least likely to donate.

27 Jun 2016

Hyde Park artist draws daily creative inspiration from chronic health experience

A kidney transplantation means much more than good health to Jason E. Jones. The 53 year-old Hyde Park artist and Loyola Medicine patient draws daily creative inspiration from his chronic health experience.

25 Jun 2016

New study shows microRNAs play important role in inducing asthma

A new study shows that microRNAs, which are small, noncoding RNA molecules that can silence genes, have an important role in inducing asthma.

24 Jun 2016

Researchers identify new potential target for pancreatic cancer treatment

Using an innovative approach to identify a cancer's genetic vulnerabilities by more swiftly analyzing human tumors transplanted into mice, researchers have identified a new potential target for pancreatic cancer treatment, published online in Cell Reports.

24 Jun 2016

Novel adaptive mechanisms in hibernating animals may provide clues to mitigate cardiac injury

Novel adaptations discovered in hibernating animals may reveal ways to mitigate injuries associated with strokes, heart attacks and organ transplants, according to researchers at the University of Alaska Fairbanks and Duke University.

23 Jun 2016

Salvage inotuzumab ozogamicin improves ALL outcomes

Compared with standard chemotherapy, treatment with inotuzumab ozogamicin increases the rate of complete remission and allows a higher proportion of patients with relapsed or refractory acute lymphoblastic leukaemia to subsequently receive stem-cell transplantation, research suggests.

22 Jun 2016

Composition of microbiota plays significant role in body's ability to accept transplanted tissue

Researchers from the University of Chicago have shown that microbiota—the bacteria, viruses and other microbes living on the skin and in the digestive system—play an important role in the body's ability to accept transplanted skin and other organs.

22 Jun 2016

Food allergies linked to diet and gut microbiome

The development of food allergies in mice can be linked to what their gut bacteria are being fed, reports a study published June 21 in Cell Reports. Rodents that received a diet with average calories, sugar, and fiber content from birth were shown to have more severe peanut allergies than those that received a high-fiber diet.

21 Jun 2016

Highly efficient bacterial agent could improve treatment of Wilson disease

In the 'Journal of Clinical Investigation', scientists at the Helmholtz Zentrum München describe a small peptide that very efficiently binds excess copper from liver cells. This molecule comes from a bacterium's bag of tricks and could be suitable for treating Wilson disease.

21 Jun 2016

Transplant News and Research

Transplant drug rapamycin may reduce nerve damage, neuropathic pain after spinal cord injury

HHV-6A human herpesvirus infects uterus lining of women with unexplained infertility

Diabetes drug metformin could help reduce toxic acid levels linked to MSUD

Emergency physicians encourage safe fireworks practices

New strategy treats fatal autoimmune disease without outward off-target effects

Surgeons outline complete face transplant procedure in facial burn patients

Study highlights role of CMV in patients with leukemia after bone marrow transplantation

LIF-treated muscle stem cells show promise in treatment of muscular dystrophy

Elevated troponin I should not rule out donor hearts

Virtual tissue technology helps identify new drug target to combat polycystic kidney disease

Researchers receive grant to improve quality of donor limb, tissue for transplant

Eye donations: what stops people? An interview with Rory Passmore

Hyde Park artist draws daily creative inspiration from chronic health experience

New study shows microRNAs play important role in inducing asthma

Researchers identify new potential target for pancreatic cancer treatment

Novel adaptive mechanisms in hibernating animals may provide clues to mitigate cardiac injury

Salvage inotuzumab ozogamicin improves ALL outcomes

Composition of microbiota plays significant role in body's ability to accept transplanted tissue

Food allergies linked to diet and gut microbiome

Highly efficient bacterial agent could improve treatment of Wilson disease

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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