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Life-threatening genetic immunodeficiency reversed by a rare DNA change

Researchers have revealed how a rare DNA change rebalanced the immune system of patients with a life-threatening genetic immunodeficiency.

1 Feb 2021

Study reveals effective therapeutic strategy to prevent colorectal cancer progression

Nagoya University researchers and colleagues have revealed that colorectal cancer tissues contain at least two types of fibroblasts (a type of cells found in connective tissue), namely, cancer-promoting fibroblasts and cancer-restraining fibroblasts, and that the balance between them is largely involved in the progression of colorectal cancer.

30 Jan 2021

COVID-19 decreased access to school meals, exacerbated food insecurity among children

School closures during COVID-19 have decreased access to school meals, which is likely to increase the risk for food insecurity among children in Maryland, according to a new report issued by researchers at the University of Maryland School of Medicine (UMSOM).

30 Jan 2021

Study finds locations of early prion protein accumulation in the eye

The earliest eye damage from prion disease takes place in the cone photoreceptor cells, specifically in the cilia and the ribbon synapses, according to a new study of prion protein accumulation in the eye by National Institutes of Health scientists.

29 Jan 2021

Study finds surprising defensive functions of the immune system against new viral attacks

Scientists are opening new windows into understanding more about the constantly shifting evolutionary arms race between viruses and the hosts they seek to infect.

29 Jan 2021

New machine learning model predicts COVID-19 severity

COVID-19 vaccine distribution has begun across the globe, while many countries are still struggling with the rampant rise of infections.

28 Jan 2021

NEI scientists develop and test a promising gene therapy strategy for rare eye disease

Scientists at the National Eye Institute have developed a promising gene therapy strategy for a rare disease that causes severe vision loss in childhood.

28 Jan 2021

Researchers develop a simple and efficient way to generate hemogenic endothelial cells

Pioneering research into how our bodies manufacture the cells that make blood has moved us closer to regrowing tissues and organs. The findings also may let doctors grow the cells for transplantation into people to battle cancer, blood disorders and autoimmune diseases.

28 Jan 2021

Genetic changes in tumors can help predict the efficacy of immunotherapy drugs

Researchers at the Francis Crick Institute, the UCL Cancer Institute, and the Cancer Research UK Lung Cancer Centre of Excellence have identified genetic changes in tumors which could be used to predict if immunotherapy drugs would be effective in individual patients.

28 Jan 2021

SMART protocol improves cognitive function, psychological well-being in laboratory participants

Many people believe that they can't change their brains, or that their brain health will inevitably decline as they age.

28 Jan 2021

Genetically engineered cartilage delivers anti-inflammatory drug in response to knee activity

Working to develop new treatments for osteoarthritis, researchers at Washington University School of Medicine in St. Louis have genetically engineered cartilage to deliver an anti-inflammatory drug in response to activity similar to the bending of a knee or other motions that put stress on joints.

27 Jan 2021

New trial to look at reducing transmission of Covid-19 in care homes

A new trial, led by experts from the University of Nottingham, will look at reducing the transmission of Covid-19 and its severity in care homes, thanks to funding from the National Institute for Health Research.

27 Jan 2021

Salk scientists receive $1.2 million from Larry L. Hillblom Foundation to study aging mechanisms

A collaborative team of Salk scientists led by Professor John Reynolds will receive $1.2 million over four years as part of a Network Grant from the Larry L. Hillblom Foundation to examine aging across the life span, including age-related neurodegenerative diseases such as Alzheimer's disease.

27 Jan 2021

Remdesivir, given to half of hospitalized covid patients in U.S., is big win for Gilead — boosted by taxpayers

It was the end of April — just as the U.S. confirmed its millionth covid-19 case and 50,000 deaths — when White House adviser Dr. Anthony Fauci announced "highly significant" news about a drug called remdesivir.

27 Jan 2021

New compound may slow aging and age-related diseases

A compound that extends lifespan in a tiny nematode worm slows bone loss in aging mice. That surprising result comes from a longitudinal and functional study of 700 aging mice at the Buck Institute, a project that provides a treasure trove of data for researchers aiming to develop therapeutics to slow aging and age-related diseases.

27 Jan 2021

Two-drug combination approach could be effective against bone cancer

An innovative approach to treating bone tumors - starving cancer cells of the energy they need to grow - could one day provide an alternative to a commonly used chemotherapy drug without the risk of severe side effects, suggests a new study from Washington University School of Medicine in St. Louis.

27 Jan 2021

Cell phone data can reveal behavioral changes in people diagnosed with flu-like illness

Cell phone data that is routinely collected by telecommunications providers can reveal changes of behavior in people who are diagnosed with a flu-like illness, while also protecting their anonymity, a new study finds.

26 Jan 2021

Novel platform uses modified virus to combat pancreatic cancer

Researchers from Queen Mary University of London and Zhengzhou University have developed a powerful therapeutic platform that uses a modified virus for the treatment of pancreatic cancer.

26 Jan 2021

Genetic interactions may shed light on NGLY1 deficiency

In 2012, four-year-old Bertrand Might became the first-ever patient diagnosed with a rare genetic disorder called N-glycanase (NGLY1) deficiency. The discovery of this condition and Bertrand's diagnosis allowed doctors to look for other children with the same genetic defect. Since then, more than 60 additional patients have been found.

26 Jan 2021

£1.6 million grant awarded to advance development of MND drug candidate

Researchers from the University of Sheffield's Institute for Translational Neuroscience have been awarded a £1.6 million grant from the Medical Research Council.

26 Jan 2021

Medical Research News and Research

Life-threatening genetic immunodeficiency reversed by a rare DNA change

Study reveals effective therapeutic strategy to prevent colorectal cancer progression

COVID-19 decreased access to school meals, exacerbated food insecurity among children

Study finds locations of early prion protein accumulation in the eye

Study finds surprising defensive functions of the immune system against new viral attacks

New machine learning model predicts COVID-19 severity

NEI scientists develop and test a promising gene therapy strategy for rare eye disease

Researchers develop a simple and efficient way to generate hemogenic endothelial cells

Genetic changes in tumors can help predict the efficacy of immunotherapy drugs

SMART protocol improves cognitive function, psychological well-being in laboratory participants

Genetically engineered cartilage delivers anti-inflammatory drug in response to knee activity

New trial to look at reducing transmission of Covid-19 in care homes

Salk scientists receive $1.2 million from Larry L. Hillblom Foundation to study aging mechanisms

Remdesivir, given to half of hospitalized covid patients in U.S., is big win for Gilead — boosted by taxpayers

New compound may slow aging and age-related diseases

Two-drug combination approach could be effective against bone cancer

Cell phone data can reveal behavioral changes in people diagnosed with flu-like illness

Novel platform uses modified virus to combat pancreatic cancer

Genetic interactions may shed light on NGLY1 deficiency

£1.6 million grant awarded to advance development of MND drug candidate

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