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Researchers uncover possible targeted therapy for new, high-risk subtype of ALL

An international research team led by St. Jude Children's Research Hospital investigators has uncovered details of a new, high-risk subtype of acute lymphoblastic leukemia (ALL) as well as a possible targeted therapy.

8 Nov 2016

High-altitude dwellers prone to chronic mountain sickness produce huge amounts of red blood cells

To better understand why some people adapt well to life at high altitude while others don't, researchers at University of California San Diego School of Medicine studied red blood cells derived from representatives of both groups living in the Andes Mountains.

7 Nov 2016

Proteins in the blood of children can predict risk for incipient type 1 diabetes

Certain proteins in the blood of children can predict incipient type 1 diabetes, even before the first symptoms appear. A team of scientists at the Helmholtz Zentrum München, partners in the German Center for Diabetes Research, reported these findings in the 'Diabetologia' journal.

7 Nov 2016

Study sheds new insights on immune cells involved in fighting dengue virus infection

India suffers from the highest number of dengue infections in the world, but there are few studies, if any, to understand the immune cells involved in fighting the virus.

21 Oct 2016

Genome engineering-based methods pave way for new treatment of patients with sickle cell disease

A team of physicians and laboratory scientists has taken a key step toward a cure for sickle cell disease, using CRISPR-Cas9 gene editing to fix the mutated gene responsible for the disease in stem cells from the blood of affected patients.

12 Oct 2016

Study suggests targeting UNG enzyme may help treat non-Hodgkin's lymphoma

Researchers have discovered that an enzyme called uracil-DNA glycosylase (UNG) protects the ends of B cell chromosomes to facilitate the proliferation of these antibody-producing cells in response to infection.

3 Oct 2016

Novel bifunctional dimers show promise in preventing Parkinson's disease

A team of researchers from the University of Saskatchewan has developed two caffeine-based chemical compounds that show promise in preventing the ravages of Parkinson's disease.

30 Sep 2016

T-Bear brings hope to kids diagnosed with cancer at Seattle Children's Hospital

He may not be able to fly, or be as fast as the speed of light, but for children who have been diagnosed with cancer at Seattle Children's, the cuddly teddy bear who wears a mask and purple cape is still a super hero to them - he gives them strength.

28 Sep 2016

Improving muscle health could enhance response to insulin in Type 1 diabetes patients

Loss of physical strength due to muscle deterioration is a complication for people living with Type 1 diabetes that's often overlooked. New research from McMaster University shows it shouldn't be.

20 Sep 2016

TSRI, IAVI scientists reveal new reductionist vaccine strategy to fight against HIV

A series of new studies led by scientists at The Scripps Research Institute and the International AIDS Vaccine Initiative describe a potential vaccination strategy to jump-start the selection and evolution of broadly effective antibodies to prevent HIV infection.

13 Sep 2016

TUM researchers use luminous jellyfish proteins to investigate cardiac rhythm dysfunctions

Cell models from stem cells serve an ever-increasing role in research of cardiac dysfunction. Researchers at the Technical University of Munich have succeeded in producing cells which offer new insights into properties of the heart.

6 Sep 2016

Researchers discover protein that plays role in onset of type 1 diabetes

A new study reveals a counterintuitive cellular strategy that may protect insulin-producing cells from destruction during type 1 diabetes.

31 Aug 2016

Researchers discover new role of cellular signaling molecule involved in release of hunger hormone

Researchers at UT Southwestern Medical Center have identified a previously unknown role of a cellular signaling molecule involved in release of the "hunger hormone" ghrelin, a finding that could have implications for optimal treatment of children taking beta blockers.

23 Aug 2016

ICR researchers identify how genetic variant linked to leukaemia helps cancer cells survive

Scientists at The Institute of Cancer Research, London, have identified how an inherited genetic variant, associated with an increased risk of developing the most common type of leukaemia, helps cancer cells survive. The findings could lead to new ways to target the disease.

12 Aug 2016

Scientists find new functions of ANG protein that plays key role in regulation of blood cell formation

Tufts Medical Center and Tufts University scientists have found exciting, new functions of the protein angiogenin that play a significant role in the regulation of blood cell formation, important in bone marrow transplantation and recovery from radiation-induced bone marrow failure.

11 Aug 2016

Olympics officials find potential new trend in doping among athletes

Olympics officials already contending with the illegal use of steroids among athletes are now being proactive about a potential new trend in performance enhancement: gene doping.

10 Aug 2016

SBP researchers discover potential drug target for treatment of type 2 diabetes

Researchers at the Sanford Burnham Prebys Medical Discovery Institute (SBP) have identified a new potential target for drugs to prevent type 2 diabetes. A paper published today in the Journal of Clinical Investigation shows that blocking a cellular glucose sensor in muscle improves insulin responsiveness.

10 Aug 2016

Research findings could lead to development of improved breast cancer drugs

Biomedical scientists have revealed the inner workings of a group of proteins that help to switch critical genes on and off during blood-cell production, in a finding that could lead to the development of new and improved cancer drugs.

9 Aug 2016

Triple therapy approach helps Type 1 diabetes patients improve blood sugar control, lose weight

A combination of three medications—dapagliflozin, liraglutide and insulin—helped people with Type 1 diabetes improve blood sugar control and lose weight, according to a new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism.

5 Aug 2016

Researchers shed light on mechanism for inducing memory B cell differentiation

A group of researchers at Immunology Frontier Research Center (IFReC), Osaka University and RIKEN Center for Integrative Medical Sciences jointly clarified the mechanism for inducing germinal-center B cells' differentiation into memory B cells, immune cells that remember antigens, at the molecular level.

2 Aug 2016