Human Leukocyte Antigen News and Research

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Roche's high-throughput sequencing technology used for high-resolution HLA genotyping

A study published this month in the journal Tissue Antigens reports that researchers at Roche Molecular Systems in Pleasanton, CA have used high-throughput sequencing technology from 454 Life Sciences, a Roche Company, to carry out high-resolution human leukocyte antigen (HLA) genotyping in research samples.

27 Oct 2009

Roche's Genome Sequencer FLX System used for critical immunogenetic study

A study published online today in the prestigious Nature Medicine journal reports that researchers at the Wisconsin National Primate Research Center have explored a new high-throughput method for decoding one of the most critical genomic regions for the immune system.

14 Oct 2009

New technique developed to assess individual's risk for type 1 diabetes

A sophisticated computational algorithm, applied to a large set of gene markers, has achieved greater accuracy than conventional methods in assessing individual risk for type 1 diabetes.

9 Oct 2009

Research on blood transfusions points to a potential risk of transfusing donated platelets

Doctors have noticed a pattern in performing bone marrow transplants as a cure for diseases involving bone marrow failure: more transfusions before a bone marrow transplant correlates with a higher likelihood of rejection, says James Zimring, MD, PhD, assistant professor of pathology and laboratory medicine at Emory University School of Medicine.

12 Aug 2009

Amazonian tribe sheds light on causes of heart attacks and strokes in developed countries

Heart attacks and strokes — the leading causes of death in the United States and other developed countries — may have been rare for the vast majority of human history, suggests a study to be published in PLoS ONE on Tuesday, August 11.

10 Aug 2009

Future of organ transplantation - microscopic beads that create "designer " immune cells

The future of organ transplantation could include microscopic beads that create "designer" immune cells to help patients tolerate their new organ, Medical College of Georgia researchers say.

6 Jul 2009

New test detects genetic and chromosomal abnormalities in embryos - ready for clinical trials

One-step screening for both genetic and chromosomal abnormalities has come a stage closer as scientists announced that an embryo test they have been developing has successfully screened cells taken from spare embryos that were known to have cystic fibrosis.

30 Jun 2009

Woman's placenta new source for harvesting stem cells

A groundbreaking study conducted by Children's Hospital & Research Center Oakland is the first to reveal a new avenue for harvesting stem cells from a woman's placenta, or more specifically the discarded placentas of healthy newborns.

23 Jun 2009

Discovery of genetic cause for primary biliary cirrhosis

Researchers have discovered a novel molecular path that predisposes patients to develop primary biliary cirrhosis, a disease that mainly affects women and slowly destroys their livers. Primary biliary cirrhosis has no known cause.

27 May 2009

Study reveals current multi-component vaccines may need reworking

Current strategies for designing vaccines against HIV and cancers, for instance, may enable some components in multi-component vaccines to cancel the effect of others on the immune system, eliminating their ability to provide protection, according to an article to be published shortly in the Proceedings of the National Academy of Sciences (PNAS).

7 May 2009

Mutations that help HIV hide undermine the virus's ability to replicate

When HIV infects a cell, a complex of human immune proteins called HLA (short for human leukocyte antigen) alert killer T cells by displaying bits of the virus on the surface of the cell. The T cells recognize these HIV fragments and mobilize an attack.

13 Apr 2009

Genetic risk factors play role in autoantibody-negative rheumatoid arthritis

During the past few years, several new genetic risk factors for rheumatoid arthritis (RA) have been identified.

8 Apr 2009

Trial shows safety of pre-transplant expansion of umbilical cord blood stem cells

Taking blood stem cells collected from an umbilical cord into the lab and expanding their number before transplanting them to replace a patient's blood supply is as safe as a standard cord blood transplant, researchers reported at the 50th Annual Meeting of the American Society of Hematology.

8 Dec 2008

Human Leukocyte Antigen News and Research

Roche's high-throughput sequencing technology used for high-resolution HLA genotyping

Roche's Genome Sequencer FLX System used for critical immunogenetic study

New technique developed to assess individual's risk for type 1 diabetes

Research on blood transfusions points to a potential risk of transfusing donated platelets

Amazonian tribe sheds light on causes of heart attacks and strokes in developed countries

Future of organ transplantation - microscopic beads that create "designer " immune cells

New test detects genetic and chromosomal abnormalities in embryos - ready for clinical trials

Woman's placenta new source for harvesting stem cells

Discovery of genetic cause for primary biliary cirrhosis

Study reveals current multi-component vaccines may need reworking

Mutations that help HIV hide undermine the virus's ability to replicate

Genetic risk factors play role in autoantibody-negative rheumatoid arthritis

Trial shows safety of pre-transplant expansion of umbilical cord blood stem cells

Study points to one cause of higher rates of transplanted kidney rejection in blacks

Statistical modeling improves quality of laboratory data

Northwestern Memorial trial may wean kidney transplant patients off antirejection drugs

Experimental procedure induces tolerance to mismatched kidney transplants

Role of genetics in multiple sclerosis

Discovery of way to match pathogens to their antibodies

Omega-3 fatty acids may reduce type 1 diabetes risk in children

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