Endocrine News and Research

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Findings increase understanding of how an organism's body size is determined and how the speed of its development is controlled

In particular, the work sheds light on the molecular and cellular pathways that act to convey information about a growing organism's size, as well as on pathways that use that information to correctly time critical transitional events during development.

26 Sep 2005

Increlex - first major innovation in 20 years for the treatment of growth failure

Rush University Medical Center is participating in a clinical trial to evaluate the potential benefit of the first major innovation in 20 years for the treatment of growth failure.

26 Sep 2005

Tobacco industry hindered federal and international regulations on pesticide use

The tobacco industry coordinated cross-industry campaigns to delay and weaken federal and international regulations on pesticide use, according to new findings by University of California - San Francisco (UCSF) researchers.

26 Sep 2005

Methoxychlor (MXC), a common insect pesticide may lead to reduced fertility in women

Methoxychlor (MXC), a common insect pesticide used on food crops, may interfere with proper development and function of the reproductive tract, leading to reduced fertility in women, researchers at Yale School of Medicine write in the August issue of Endocrinology.

19 Sep 2005

Methoxychlor (MXC) may interfere with proper development and function of the reproductive tract, leading to reduced fertility in women

The researchers found that MXC, which was manufactured as a safer replacement for the now-banned DDT, alters the estrogen-regulated gene Hoxa10 in the reproductive tract and reduces the ability of the uterus to support embryo implantation. The researchers used mice and then human cell lines to confirm their findings.

7 Sep 2005

New ways to enhance or block fertilization

Researchers have capitalized on the unique properties of a sperm cell to follow cell membrane fusion as it occurs during fertilization, tracking the full cascade of events for the first time. The findings could reveal new ways to enhance or block fertilization, as well as how to control the secretion of neurotransmitters and hormones such as insulin.

6 Sep 2005

SH2-B enhances brain's leptin sensitivity - may lead to clues for treatment of obesity and diabetes

What do laboratory mice at the University of Michigan Medical School have in common with millions of overweight Americans? Like many of us, these mice just can't stop eating.

18 Aug 2005

Researchers find drug targets for treating metabolic syndrome

Ongoing studies by researchers at UT Southwestern Medical Center and other institutions have uncovered the biochemical basis of many of the factors contributing to what is known as the metabolic syndrome, suggesting potential new drug targets for treating the condition.

11 Aug 2005

Switching treatment to the drug anastrozole after two years of tamoxifen is beneficial for women with early breast cancer

Switching treatment to the drug anastrozole after two years of tamoxifen can improve eventfree survival for postmenopausal women with early breast cancer, concludes a study in this week’s issue of The Lancet.

4 Aug 2005

Pedometers motivate walkers

Need motivation to walk 10,000 steps? Get a pedometer, says University of Tennessee professor Dixie Lee Thompson.

2 Aug 2005

$New protective drugs called bisphosphonates reduce pain and fractures in metastatic breast cancer$

New protective drugs called bisphosphonates reduce pain and fractures in metastatic breast cancer

When breast cancer spreads to bones, relatively new protective drugs called bisphosphonates can reduce skeletal damage, says a new systematic review of previous studies. While the new treatment approach does not improve survival rates, it can minimize disabling fractures, spinal cord compression and pain.

19 Jul 2005

Potential use of NH neurotransmitters as novel source for psychiatric drugs

Physiologists and medical researchers have long recognized the important endocrine roles played by the pituitary hormones oxytocin (OT) and vasopressin (VP) on peripheral systems in lactation, uterine contraction and urine concentration.

19 Jul 2005

Infertility may be becoming more of a man's problem than a woman's problem

Until now, approximately 40% of infertility cases have been linked to medical problems in men and 40% to medical problems in women, with the remaining 20% due to joint problems.

27 Jun 2005

Minimally invasive approach to removing diseased thyroids

An incision about half the length used for traditional surgery works just as well in removing diseased thyroids, researchers have found.

27 Jun 2005

Scientists prove that human embryonic stem cells can develop in the laboratory into the early forms of cells that eventually become eggs or sperm

Their work opens up the possibility that eggs and sperm could be grown from stem cells and used for assisted reproduction, therapeutic cloning and the creation of more stem cells for further research and for the improved treatments for patients suffering from a range of diseases.

19 Jun 2005

IGF-based growth hormone dosing could become a novel paradigm in treating growth hormone deficiency

A randomized University of California - Los Angeles (UCLA) study found that a new dosing paradigm can improve height outcomes in the treatment of children who have short stature due to growth hormone deficiency and idiopathic short stature.

6 Jun 2005

Latest research on men's health issues, treatments and lifestyle practices

Today, leading researchers are gathering at the annual meeting of The Endocrine Society in San Diego to present the latest research on men's health issues, treatments and lifestyle practices. New findings could help doctors identify risks and treat men's conditions more effectively.

6 Jun 2005

Suppression of growth hormone and related compounds beginning in early adulthood may delay the onset or progression of several types of cancer

A modest suppression of growth hormone and related compounds beginning in early adulthood may delay the onset or progression of several types of cancer, researchers from Wake Forest University School of Medicine and other centers reported today at ENDO 2005, the annual meeting of the Endocrine Society, in San Diego.

5 Jun 2005

Toxic chemicals that poisoned your great-grandparents may also damage your health

New U.S. research is suggesting that chemicals can change the way genes work and that toxic chemicals that poisoned your great-grandparents may also damage your health.

5 Jun 2005

Role of toxins in inherited disease

A disease you are suffering today could be a result of your great-grandmother being exposed to an environmental toxin during pregnancy.

3 Jun 2005

Endocrine News and Research

Findings increase understanding of how an organism's body size is determined and how the speed of its development is controlled

Increlex - first major innovation in 20 years for the treatment of growth failure

Tobacco industry hindered federal and international regulations on pesticide use

Methoxychlor (MXC), a common insect pesticide may lead to reduced fertility in women

Methoxychlor (MXC) may interfere with proper development and function of the reproductive tract, leading to reduced fertility in women

New ways to enhance or block fertilization

SH2-B enhances brain's leptin sensitivity - may lead to clues for treatment of obesity and diabetes

Researchers find drug targets for treating metabolic syndrome

Switching treatment to the drug anastrozole after two years of tamoxifen is beneficial for women with early breast cancer

Pedometers motivate walkers

New protective drugs called bisphosphonates reduce pain and fractures in metastatic breast cancer

Potential use of NH neurotransmitters as novel source for psychiatric drugs

Infertility may be becoming more of a man's problem than a woman's problem

Minimally invasive approach to removing diseased thyroids

Scientists prove that human embryonic stem cells can develop in the laboratory into the early forms of cells that eventually become eggs or sperm

IGF-based growth hormone dosing could become a novel paradigm in treating growth hormone deficiency

Latest research on men's health issues, treatments and lifestyle practices

Suppression of growth hormone and related compounds beginning in early adulthood may delay the onset or progression of several types of cancer

Toxic chemicals that poisoned your great-grandparents may also damage your health

Role of toxins in inherited disease

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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