Angiotensin News and Research

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Angiotensin is an oligopeptide in the blood that causes vasoconstriction, increased blood pressure, and release of aldosterone from the adrenal cortex. It is a powerful dipsogen. It is derived from the precursor molecule angiotensinogen, a serum globulin produced in the liver. It plays an important role in the renin-angiotensin system.

Telmisartan potent against stroke

Telmisartan, a drug widely used to help control blood pressure, may have uniquely potent activity in preventing stroke, according to a new study conducted in an animal model.

13 Dec 2007

Approval of Diovan (valsartan) in U.S. for hypertension in children and adolescents

Diovan (valsartan), an angiotensin receptor blocker or ARB, has been approved following a priority review by the U.S. Food and Drug Administration (FDA) for the treatment of high blood pressure in children and adolescents ages six to 16.

4 Dec 2007

Captopril may limit radiation kidney damage in bone marrow transplant patients

Researchers at the Medical College of Wisconsin in Milwaukee have found that the risk of radiation injury in normal tissue after exposure may be reduced by a drug in common use. Their study in press appears in the on line issue of the International Journal of Radiation Oncology, Biology and Physics.

15 Nov 2007

Potential block buster on the horizon - new vaccine to control high blood pressure

A vaccine that would help people control their blood pressure is showing promise in early trials.

7 Nov 2007

Novel approaches to hypertension control

A hypertension vaccine could be an important alternative to conventional drug therapy because of patients' inconsistent drug intake - if further research supports results from a small study testing the safety and tolerability of a vaccine.

6 Nov 2007

More effective method of treating high blood pressure

Scientists at Robarts Research Institute have developed a simplified and more effective method of treating high blood pressure.

6 Nov 2007

Common blood pressure medications ACEIs and ARBs provide equal control

Two common classes of blood pressure medications – angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) – are equally effective at controlling high blood pressure, according to a report released by the Agency for Healthcare Research and Quality, part of the U.S. Department of Health and Human Services.

5 Nov 2007

Hypertension drugs may prevent Alzheimer's Disease

New research is suggesting that some of the drugs commonly used to treat hypertension (high blood pressure) may offer another benefit.

28 Oct 2007

Blood levels of progesterone may impact blood vessel function

Blood levels of progesterone, a major female sex hormone, may play an important role in modifying vascular function in postmenopausal women, according to a new study accepted for publication in the Journal of Clinical Endocrinology & Metabolism (JCEM).

16 Oct 2007

Heart drug perindopril helps seniors get active

According to scientists from Dundee University in Scotland, when seniors were given a drug commonly prescribed for heart conditions they were able to do more exercise.

10 Oct 2007

Perindopril for improving physical function in elderly people

A decline in physical function with age is strongly associated with disability in later life.

9 Oct 2007

ACE inhibitor perindopril may help improve cardiac complications from Marfan syndrome

Preliminary research suggests that use of the ACE inhibitor perindopril, along with a beta-blocker, may help reduce cardiac measures such as aortic stiffness and dilation that are associated with the cardiac complications of Marfan syndrome, according to an article in the October 3 issue of JAMA.

3 Oct 2007

Reducing enlarged heart decreases risk of heart failure

For high-blood-pressure patients, preventing or reducing enlarged heart (left ventricular hypertrophy or LVH) reduces risk of heart failure.

13 Sep 2007

Gene-drug interactions that lower blood pressure

Patients with high blood pressure respond very differently to antihypertensive medication, making treatment selection tricky for physicians.

13 Sep 2007

Preventing enlarged heart reduces heart failure

For high-blood-pressure patients, preventing or reducing enlarged heart (left ventricular hypertrophy or LVH) reduces risk of heart failure. The study is published in the Sept. 4 Annals of Internal Medicine and led by physician-scientists at NewYork-Presbyterian Hospital/Weill Cornell Medical Center in New York City.

11 Sep 2007

Congestive heart failure is rare among leukemia patients who take imatinib

Congestive heart failure rarely occurs among leukemia patients who take imatinib, researchers at The University of Texas M. D. Anderson Cancer Center found after an exhaustive review of the detailed medical histories of 1,276 patients who enrolled in clinical trials for the drug.

10 Sep 2007

The burden of diabetes in heart disease in Europe

Diabetes is becoming one of the major health problems in the European and US populations. It is frequently associated with overweight, hypertension and high serum cholesterol levels, representing a dangerous combination of risk factors for the development of heart and vascular diseases.

2 Sep 2007

Blood pressure drugs cut death rate in diabetes

The largest-ever study of treatments for diabetes has shown that a fixed combination of two blood pressure lowering drugs reduces the risk of death, as well as the risks of heart and kidney disease. Results from the ADVANCE (Action in Diabetes and Vascular Disease) Study were presented today at the European Society of Cardiology Congress 2007 in Vienna.

2 Sep 2007

The first clinically available oral direct renin inhibitor shows promise in heart failure

Drugs that block a hormonal cascade, known as the renin-angiotensin-aldosterone system (RAAS), help patients with heart failure. Direct renin inhibitors (DRIs) block the RAAS at its first and rate-limiting step.

2 Sep 2007

Specific antagonism lowers blood pressure

High blood pressure (hypertension) is associated with an increased risk of heart attack and stroke, and the frequent use of drugs known as NSAIDs, for example to treat individuals with rheumatoid arthritis, can cause hypertension.

17 Aug 2007