Cancer Immunotherapy News and Research

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Restoring beneficial gut microbes to enhance the efficacy of cancer immunotherapy

The gut microbiome-;the collection of bacteria, viruses, fungi, and other microorganisms that reside in our gastrointestinal tracts-;can impact us in a variety of different ways, from our metabolism to our mood.

9 Sep 2021

Researchers uncover underlying metabolic changes that are linked to COVID-19 severity

COVID-19 patients have differing immune responses that lead to disease outcomes ranging from asymptomatic SARS-CoV-2 infection to death.

6 Sep 2021

CAR T cells expressing a natural RNA can activate the body’s own T cells against solid tumors

Chimeric antigen receptor (CAR) T cell therapy, which uses engineered T cells to treat certain types of cancers, has often been a challenging approach to treating solid tumors. CAR T cells need to recognize a specific target on cancer cells to kill them.

2 Sep 2021

New review looks at the bottlenecks and breakthroughs in cancer immunotherapy

After over a century of development, cancer immunotherapy (CIT) has risen to become a promising approach for treating cancer. Unlike conventional methods that try to kill cancer cells directly, CIT involves modifying or stimulating the immune system's natural ability to fight the disease. So far, various CIT treatments have shown remarkable results in terms of survival rates, and many new and combination strategies are currently under study.

1 Sep 2021

MSK researchers identify potential biomarker of response to checkpoint immunotherapy

In recent years, immune-based treatments for cancer have buoyed the hopes of doctors and patients alike. Drugs called immune checkpoint inhibitors have provided lifesaving benefits to a growing list of people with several types of cancer, including melanoma, lung cancer, bladder cancer, and many more.

25 Aug 2021

UCLA scientists receive $1 million translational award to advance CAR T cell therapy for rare melanomas

Scientists Dr. Cristina Puig-Saus and Dr. Daniel Shin from the UCLA Jonsson Comprehensive Cancer Center have received a $1 million Translational Research Award from the U.S. Department of Defense Melanoma Research Program to help advance the use of chimeric antigen receptor, or CAR, T cell therapy as a treatment for people with acral, mucosal and uveal melanomas.

24 Aug 2021

Researchers create a novel strategy for developing an effective TB vaccine

Innovators at Purdue University and Houston Methodist Research Institute have created a novel strategy for developing an effective vaccine for a widespread form of tuberculosis.

20 Aug 2021

Dysregulation of innate lymphoid cells drives colon cancer progression and immunotherapy resistance

An immune cell subset called innate lymphoid cells (ILC3s) protects against colorectal cancer, in part by helping to maintain a healthy dialogue between the immune system and gut microbes, according to a new study led by researchers at Weill Cornell Medicine and NewYork-Presbyterian. The finding opens the door to new strategies for treating this type of cancer.

17 Aug 2021

Combining inhibitor drug with immunotherapy agent improves response in cancer patients

Combining a histone deacetylase inhibitor drug with immunotherapy agents is safe, and may benefit some patients with advanced cancers that have not responded to traditional therapy, according to results of a phase 1 clinical trial led by researchers at the Johns Hopkins Kimmel Cancer Center, Bloomberg~Kimmel Institute for Cancer Immunotherapy and several other centers including University of Pittsburgh Cancer Institute, Yale Cancer Center and City of Hope in Los Angeles, which participated in study enrollment, and the University of Southern California and University College Cork in Ireland, which collaborated on analysis of the data.

16 Aug 2021

Immunotherapy pairs ultrasound with immune cells to destroy tumors without toxic side effects

Bioengineers at the University of California San Diego have developed a cancer immunotherapy that pairs ultrasound with cancer-killing immune cells to destroy malignant tumors while sparing normal tissue.

12 Aug 2021

Magnetic nanoparticles could enhance the efficacy of cancer immunotherapy

Boosting the function of natural killer cells with magnetic nanoparticles could make cancer immunotherapy more efficient.

6 Aug 2021

K-State research team aims to improve immunotherapy treatment for cancer patients

Immunotherapy can leverage the body's immune system to fight cancer. While excellent responses have been observed for some patients, a considerably larger number have received little benefit.

4 Aug 2021

New PET imaging method tracks immunotherapeutic efficacy in mouse models

Several cancer tumors grow through immunosuppression; that is, they manipulate biological systems in their microenvironments and signal to a specific set of immune cells--those that clear out aberrant cells--to stop acting. It is no wonder that immunotherapy designed to re-establish anti-tumor immunity is rapidly becoming the treatment of choice for these cancers.

2 Jul 2021

Researchers develop engineered yeast probiotic for treatment of inflammatory bowel disease

The world of microbes living in the human gut can have far-reaching effects on human health. Multiple diseases, including inflammatory bowel disease (IBD), are tied to the balance of these microbes, suggesting that restoring the right balance could help treat disease.

28 Jun 2021

Promising immunotherapy uses cancer-killing cells to destroy malignant tumors

Researchers at McMaster University have developed a promising new cancer immunotherapy that uses cancer-killing cells genetically engineered outside the body to find and destroy malignant tumors.

28 Jun 2021

Anti-cancer prodrug can benefit cancer patients

Unlike conventional cancer drugs that attack and kill cancer cells directly, anti-cancer immunotherapy, which kills cancer cells by strengthening the body's immunity, is a novel type of cancer treatment currently attracting increased attention. Unfortunately, a minority of cancer patients who have some degree of pre-existing immunity only benefit from anti-cancer immunotherapy.

28 Jun 2021

Study: A subset of patients with localized prostate cancer may benefit from immunotherapies

In recent years, cancer immunotherapy has been effective in treating patients with immunogenic, or so-called "hot" tumors with increased levels of inflammation and the presence of immune cells in and around the tumors.

24 Jun 2021

Cancer immunotherapy may self-limit its efficacy in fighting tumors, study finds

Cancer immunotherapy involving drugs that inhibit CTLA-4 also activates an unwanted response that may self-limit its efficacy in fighting tumors, according to a new study led by Francesco Marangoni, Ph.D., assistant professor of physiology & biophysics and member of the Institute for Immunology at the University of California, Irvine.

22 Jun 2021

UCSF launches new initiative to propel the development of living therapeutics

UC San Francisco is launching a new initiative to propel the development of living therapeutics - a category of treatments broadly defined as human and microbial living cells that are selected, modified, or engineered to treat or cure disease - and bring them quickly to patients.

14 Jun 2021

Common antidepressant drugs help the immune system to attack tumors in mice

A class of drug called monoamine oxidase inhibitors is commonly prescribed to treat depression; the medications work by boosting levels of serotonin, the brain's "happiness hormone."

10 Jun 2021

Cancer Immunotherapy News and Research

Restoring beneficial gut microbes to enhance the efficacy of cancer immunotherapy

Researchers uncover underlying metabolic changes that are linked to COVID-19 severity

CAR T cells expressing a natural RNA can activate the body’s own T cells against solid tumors

New review looks at the bottlenecks and breakthroughs in cancer immunotherapy

MSK researchers identify potential biomarker of response to checkpoint immunotherapy

UCLA scientists receive $1 million translational award to advance CAR T cell therapy for rare melanomas

Researchers create a novel strategy for developing an effective TB vaccine

Dysregulation of innate lymphoid cells drives colon cancer progression and immunotherapy resistance

Combining inhibitor drug with immunotherapy agent improves response in cancer patients

Immunotherapy pairs ultrasound with immune cells to destroy tumors without toxic side effects

Magnetic nanoparticles could enhance the efficacy of cancer immunotherapy

K-State research team aims to improve immunotherapy treatment for cancer patients

New PET imaging method tracks immunotherapeutic efficacy in mouse models

Researchers develop engineered yeast probiotic for treatment of inflammatory bowel disease

Promising immunotherapy uses cancer-killing cells to destroy malignant tumors

Anti-cancer prodrug can benefit cancer patients

Study: A subset of patients with localized prostate cancer may benefit from immunotherapies

Cancer immunotherapy may self-limit its efficacy in fighting tumors, study finds

UCSF launches new initiative to propel the development of living therapeutics

Common antidepressant drugs help the immune system to attack tumors in mice

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