Phenotype News and Research

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Higher intake of flavonols linked to lower risk of frailty onset in adults

This study aimed to investigate the association between dietary flavonoids, their subclasses, quercetin, and frailty onset in adults. The results suggest that higher intake of flavonols, particularly quercetin, may be associated with a lower risk of frailty onset.

17 Apr 2023

Study unearths 12 different cell types involved in the pathogenesis of coronary artery disease

A new study from the University of Eastern Finland identified 12 different cell types involved in the pathogenesis of coronary artery disease, CAD.

17 Apr 2023

Phenotype-tailored lifestyle interventions show promising weight loss results in obese adults

Researchers assess the effectiveness of a phenotype-tailored lifestyle intervention on weight loss in obese adults.

16 Apr 2023

Study endeavors to strengthen genomic diagnosis of rare pediatric diseases in the United Kingdom and Ireland

Researchers performed a large-scale sequencing study using data gathered over a decade from a previous study.

14 Apr 2023

COVID mRNA vaccines fall short in eliciting lung resident memory T cells compared to natural infection

Pieren, D. K. J., Kuguel, S. G., Rosado, J., Robles, A. G., Rey-Cano, J., Mancebo, C., Esperalba, J., Falcó, V., Buzón, M. J., & Genescà, M. (2023). Limited induction of polyfunctional lung-resident memory T cells against SARS-CoV-2 by mRNA vaccination compared to infection. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-37559-w, https://www.nature.com/articles/s41467-023-37559-w

10 Apr 2023

Interplay between Western diet, gut microbiota, and cancer development

In a review article published in the journal Seminars in Immunology, scientists have explored the relationship between the Western diet, gut microbiota, and cancer development.

4 Apr 2023

Study assesses the cellular and molecular immunopathology of post-COVID lung disease

Researchers assessed the cellular and molecular level immunopathology of PCLD.

4 Apr 2023

BU researcher wins $3.9 million NIH grant to develop novel therapeutic modalities for Alzheimer's

Julia TCW, PhD, assistant professor of pharmacology & experimental therapeutics at Boston University Chobanian & Avedisian School of Medicine, has received a five-year, $3.9 million grant from the National Institutes of Health's National Institute on Aging.

3 Apr 2023

Red blood cell hitch-hiking facilitates SARS-CoV-2 multi-organ spread

Researchers assessed the infectious capacity of severe acute respiratory syndrome coronavirus 2 in plasma and red blood cells.

3 Apr 2023

Utilizing a molecular syringe for the delivery of functional proteins into human cells with high efficiency

Researchers investigated the feasibility of utilizing a bacterial contractile injection system for programmable protein delivery.

31 Mar 2023

Using a selective dye to label macrophages associated with cancer progression

M1 and M2 are activated macrophages that protect our immune system and maintain homeostasis.

28 Mar 2023

Exploring the complexities of antimicrobial resistance forecasting

Researchers highlight the need for prioritizing research on antimicrobial-resistant organism forecasting.

23 Mar 2023

Menin protein protects against aging and cognitive decline

In a recent study published in the journal PLoS Biology, researchers from the University of Xiamen, China, explored the role of the hypothalamic menin in driving aging and associated cognitive decay.

23 Mar 2023

Pet dogs across the USA are becoming increasingly resistant to benzimidazole treatment

In a recent study published in the journal PLOS Pathogens, researchers in the United States of America (USA) and Canada found molecular evidence that the parasitic hookworms (Ancylostoma caninum) in pet dogs across the USA are becoming increasingly resistant to benzimidazole, a broad-spectrum anthelmintic drug used for infection control.

22 Mar 2023

Higher plasma caffeine concentrations might reduce body fat and type 2 diabetes risk

In a recent study published in the journal BMJ Medicine, researchers in the United Kingdom and Sweden investigated the probable causality of long-term serum caffeine concentrations on type 2 diabetes (T2D), adiposity, and major cardiovascular diseases (CVDs).

22 Mar 2023

Novel subset of memory B cells predicts long-lived antibody responses to influenza vaccination

Memory B cells play a critical role to provide long-term immunity after a vaccination or infection. In a study published in the journal Immunity, researchers describe a distinct and novel subset of memory B cells that predict long-lived antibody responses to influenza vaccination in humans.

22 Mar 2023

Tetravalent COVID vaccine provides broad antibody responses against SARS-CoV-2 variants in animal model

In a recent study posted to the bioRxiv* preprint server, researchers in Italy and the United States evaluated the efficacy and immunogenicity of an adjuvanted tetravalent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein subunit 1 (S1) COVID-19 vaccine.

21 Mar 2023

Research shows the role of PCYT2-mediated lipid synthesis in vertebrate muscle health

Muscle degeneration, the most prevalent cause of frailty in hereditary diseases and aging, could be caused by a deficiency in one key enzyme in a lipid biosynthesis pathway.

20 Mar 2023

New SARS-CoV-2 Omicron XBB.1.5 variant has high transmissibility and infectivity, study finds

COVID-19 has caused significant global panic after its rapid emergence more than 3 years ago. Although we now have highly effective vaccines against the SARS-CoV-2 virus, which causes COVID-19, scientists continue to study emerging SARS-CoV-2 variants in order to safeguard public health and devise global preventive strategies against emerging variants.

20 Mar 2023

Gut microbiomes and mental health: how do they interact?

A new study published in the journal Frontiers in Medicine reviewed recent literature on the link between gut microbiota, the brain, and neurological disorders.

19 Mar 2023

Phenotype News and Research

Higher intake of flavonols linked to lower risk of frailty onset in adults

Study unearths 12 different cell types involved in the pathogenesis of coronary artery disease

Phenotype-tailored lifestyle interventions show promising weight loss results in obese adults

Study endeavors to strengthen genomic diagnosis of rare pediatric diseases in the United Kingdom and Ireland

COVID mRNA vaccines fall short in eliciting lung resident memory T cells compared to natural infection

Interplay between Western diet, gut microbiota, and cancer development

Study assesses the cellular and molecular immunopathology of post-COVID lung disease

BU researcher wins $3.9 million NIH grant to develop novel therapeutic modalities for Alzheimer's

Red blood cell hitch-hiking facilitates SARS-CoV-2 multi-organ spread

Utilizing a molecular syringe for the delivery of functional proteins into human cells with high efficiency

Using a selective dye to label macrophages associated with cancer progression

Exploring the complexities of antimicrobial resistance forecasting

Menin protein protects against aging and cognitive decline

Pet dogs across the USA are becoming increasingly resistant to benzimidazole treatment

Higher plasma caffeine concentrations might reduce body fat and type 2 diabetes risk

Novel subset of memory B cells predicts long-lived antibody responses to influenza vaccination

Tetravalent COVID vaccine provides broad antibody responses against SARS-CoV-2 variants in animal model

Research shows the role of PCYT2-mediated lipid synthesis in vertebrate muscle health

New SARS-CoV-2 Omicron XBB.1.5 variant has high transmissibility and infectivity, study finds

Gut microbiomes and mental health: how do they interact?

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