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Modified form of poliovirus shows potential as cancer vaccine in animal studies

A modified form of poliovirus, pioneered at Duke Cancer Institute as a therapy for glioblastoma brain tumors, appears in laboratory studies to also have applicability for pediatric brain tumors when used as part of a cancer vaccine.

31 Jan 2020

Prostate cancer is the most commonly diagnosed cancer in England

In the health agency’s report, there were 49,029 diagnoses made in 2018, which is about 8,000 more than the previous year, surpassing breast cancer with 47,476 cases. Lung cancer followed with 38,996 cases. The new data reveals that there were more cancers detected in 2018 in men than in women, with a total of 15,228 cases and 151,452, respectively.

28 Jan 2020

Study reveals new "crosstalk" between intestinal microbes and developing thymic cells

Newborns face unique immunological challenges immediately after birth. As they depart a relatively sterile fetal environment, they are abruptly exposed to a multitude of foreign antigens, the major burden of which is in the form of the microbiota newly colonizing the gastrointestinal tract.

24 Jan 2020

Drug profiling and gene editing method open new avenues in the development of CAR T-cell therapy

Researchers have discovered ways to boost CAR T-cell therapy.

21 Jan 2020

Discovery of new killer T-cell offers hope of a 'one-size-fits-all' cancer therapy

Researchers at Cardiff University have discovered a new type of killer T-cell that offers hope of a "one-size-fits-all" cancer therapy.

21 Jan 2020

Lab tests reveal that newly discovered T-cell can kill various types of cancer

Scientists have discovered a T-cell receptor that has proven effective in targeting a variety of cancers in mice and in human cells within the lab.

21 Jan 2020

Enzymes that cannibalize each other and promote cancer

A new study to be published this week in the journal The Proceedings of the National Academy of Sciences in the week of January 20, 2020. shows that certain human enzymes play dual roles in health and disease. Not only do they promote the occurrence of cancer and some other illnesses, they also eliminate one another rather like cannibals. The researchers hope this behaviour can be exploited to prevent these enzymes from causing human disease.

20 Jan 2020

Genetically engineered mosquitoes halt Dengue spread

A new study published in the journal PLOS Pathogens in January 2020 reports the development of mosquitoes that have been genetically modified to resist infection by several types of the dengue virus. This is the first time ever that all types of the virus have been targeted by the engineering of the mosquito DNA. Covering all virus types is essential to achieve proper disease control.

16 Jan 2020

B cell count tells how certain cancers will respond to immunotherapy

Some melanomas, sarcomas and renal cell carcinomas, but not all, have been found to respond dramatically to new drugs called immune checkpoint blockers, which exploit the body’s known capability to mount an immune response against the foreign antigen-bearing tumor cells.

15 Jan 2020

Biomaterial-based vaccine has potential to completely eliminate AML cells

Acute myeloid leukemia (AML) is a deadly blood cancer that originates in the bone marrow and kills most of its victims within five years. Chemotherapy has been the standard AML treatment for over 40 years, and while it often causes the cancer to go into remission, it rarely completely eliminates the cancerous cells, which then lead to disease recurrence in nearly half of treated patients.

14 Jan 2020

Increased Vegetable Intake Fails to Slow Prostate Cancer Progression, Study Finds

Researchers in the United States have conducted a study investigating whether a telephone-based interventional program encouraging an increased intake of vegetables would slow disease progression among patients with early-stage prostate cancer.

14 Jan 2020

A protein found in ovarian cancer may contribute to neurodegeneration in Alzheimer's disease

Houston Methodist scientists identified a protein found in ovarian cancer that may contribute to declining brain function and Alzheimer's disease, by combining computational methods and lab research.

13 Jan 2020

Rejuvenating the BCG Vaccine

A new primate study published in the journal Nature in January 2020, reports that the almost century-old BCG vaccine against tuberculosis, may be used differently to achieve better protection against lung tuberculosis. While more work remains to be carried out before the findings can be accepted as the basis for clinical practice, they are extremely promising in the fight against this killer.

10 Jan 2020

Integral Molecular announces panel of P2X7 antibodies for autoimmune disorders

Integral Molecular, the leader in discovering antibodies against multipass membrane proteins, announces lead monoclonal antibodies (MAbs) against P2X7, a structurally complex ion channel that is the target for autoimmune disorders including atopic dermatitis and glomerulonephritis.

10 Jan 2020

Administering enzalutamide results in significant increase in PSMA density on tumor surface

When a non-scientist tries to imagine a scientist, the image that often arises is one of a somewhat remote, rather idealistic genius sitting alone in their room or laboratory and somehow discovering the most amazing things without every having contact with the 'normal' world.

9 Jan 2020

Breastfeeding mothers could naturally vaccinate their babies against malaria

In a world first, researchers from The University of Western Australia have taken the first step towards understanding whether it may be possible for breastfeeding mothers to naturally vaccinate their babies against malaria – one of the world’s deadliest contagious diseases.

9 Jan 2020

Researchers one step closer to developing vaccines that protect infants against infections

A new Penn Medicine study puts researchers within closer reach of vaccines that can protect infants against infections by overcoming a mother's antibodies, which are known to shut down immune defenses initiated by conventional vaccines.

9 Jan 2020

Growing influenza vaccines inside chicken eggs can make them less effective, say some experts

Flu season is underway in the Northern Hemisphere, sickening millions of people and in rare cases, causing hospitalization or death. The best prevention is a flu shot, but it's not unusual for these vaccines to be less effective than intended. Some researchers suspect that the common practice of producing vaccines in chicken eggs could be partially to blame, according to an article in Chemical & Engineering News (C&EN), the weekly newsmagazine of the American Chemical Society.

8 Jan 2020

Study shows potential new approach to treating two common subtypes of lymphoma

A study at The University of Texas MD Anderson Cancer Center demonstrated a potential new approach to treating two of the most common subtypes of lymphoma through manipulation of molecular programs controlled by the cAMP-response element binding protein.

8 Jan 2020

Novel nanoparticle vaccine provides long-lasting protection against influenza virus

A novel nanoparticle vaccine that combines two major influenza proteins is effective in providing broad, long-lasting protection against influenza virus in mice, showing promise as a universal flu vaccine, according to a study by the Institute for Biomedical Sciences at Georgia State University.

7 Jan 2020

Antigen News and Research

Modified form of poliovirus shows potential as cancer vaccine in animal studies

Prostate cancer is the most commonly diagnosed cancer in England

Study reveals new "crosstalk" between intestinal microbes and developing thymic cells

Drug profiling and gene editing method open new avenues in the development of CAR T-cell therapy

Discovery of new killer T-cell offers hope of a 'one-size-fits-all' cancer therapy

Lab tests reveal that newly discovered T-cell can kill various types of cancer

Enzymes that cannibalize each other and promote cancer

Genetically engineered mosquitoes halt Dengue spread

B cell count tells how certain cancers will respond to immunotherapy

Biomaterial-based vaccine has potential to completely eliminate AML cells

Increased Vegetable Intake Fails to Slow Prostate Cancer Progression, Study Finds

A protein found in ovarian cancer may contribute to neurodegeneration in Alzheimer's disease

Rejuvenating the BCG Vaccine

Integral Molecular announces panel of P2X7 antibodies for autoimmune disorders

Administering enzalutamide results in significant increase in PSMA density on tumor surface

Breastfeeding mothers could naturally vaccinate their babies against malaria

Researchers one step closer to developing vaccines that protect infants against infections

Growing influenza vaccines inside chicken eggs can make them less effective, say some experts

Study shows potential new approach to treating two common subtypes of lymphoma

Novel nanoparticle vaccine provides long-lasting protection against influenza virus

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