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Insulin is a hormone that is needed to convert glucose, starches and other food into energy needed for daily life. Insulin allows cells to use glucose for fuel and is secreted by beta cells in the islets of Langerhans. The release of insulin from the pancreas is stimulated by increased blood glucose, vagal nerve stimulation, and other factors. Insulin is obtained from various animals and available in a variety of preparations. Commercial insulin preparations differ in a number of ways, including differences in the animal species from which they are obtained; their purity, concentration, and solubility; and the time of onset and duration of their biologic action. An oral hypoglycemic agent is not a form of insulin therapy.

Penn researchers identify genome-wide changes caused by high-fat diet

By comparing two strains of mice -- one that becomes obese and diabetic on a high-fat diet and another resistant to a high-fat regimen -- researchers from the Perelman School of Medicine at the University of Pennsylvania identified genome-wide changes caused by a high-fat diet.

8 Mar 2017

Researchers justify alternative theory about cause of type 1 diabetes

An international team of researchers led by City of Hope's Bart Roep, Ph.D., the Chan Soon-Shiong Shapiro Distinguished Chair in Diabetes and professor/founding chair of the Department of Diabetes Immunology, has been able to justify an alternative theory about the cause of type 1 diabetes (T1D) through experimental work.

28 Feb 2017

Researchers aim to develop sustained and controllable insulin release system for treatment of diabetes

The prevalence of diabetes has grown around the world over the past three decades. In 2016, the World Health Organization estimated that 422 million people had the disease as the rate of obesity also increased.

27 Feb 2017

Universal public coverage of essential medicines could save over $4 billion per year, study finds

Universal public coverage of 117 essential medicines could address the needs of most Canadians for pharmaceutical drugs, and possibly save more than $4 billion a year, according to a new study published http://www.cmaj.ca/site/press/cmaj.161082.pdf in CMAJ.

27 Feb 2017

Feast and famine diet may restore insulin production in diabetes

A landmark study conducted by the University of Southern California and published this week in the journal Cell provides hope for restoring insulin production in patients with diabetes. The study showed that when food is restored to mice on a very low calorie diet that mimics fasting, new insulin-producing cells develop.

24 Feb 2017

Physician-delivered step count prescription combined with use of pedometer can provide health benefits

A study from the Research Institute of the McGill University Health Centre shows that physician-delivered step count prescriptions, combined with the use of a pedometer, can lead to a 20 per cent increase in daily steps, as well as measurable health benefits, such as lower blood sugar and lower insulin resistance, for patients with hypertension and/or type 2 diabetes.

24 Feb 2017

Scientists establish ‘tipping point’ molecular link between blood sugar and Alzheimer's disease

For the first time a "tipping point" molecular link between the blood sugar glucose and Alzheimer's disease has been established by scientists, who have shown that excess glucose damages a vital enzyme involved with inflammation response to the early stages of Alzheimer's.

24 Feb 2017

BIDMC review focuses on neural circuitry of wakefulness and sleep

Sleep remains an enduring biological mystery with major clinical relevance, according to a review by clinician-researcher Thomas Scammell, MD, of Beth Israel Deaconess Medical Center (BIDMC) and colleagues.

23 Feb 2017

Epigenetic changes that affect formation of new muscle cells may be contributing factor to obesity

Obesity is associated with reduced muscle mass and impaired metabolism. Epigenetic changes that affect the formation of new muscle cells may be a contributing factor, according to new research from Lund University, Sweden.

22 Feb 2017

Anti-epilepsy medicine use during pregnancy does not harm overall health of children, study finds

Children whose mothers have taken anti-epilepsy medicine during pregnancy, do not visit the doctor more often than children who have not been exposed to this medicine in utero. This is the result of a new study from Aarhus.

21 Feb 2017

Mice study provides clues to how genetic variations in gut microbes influence metabolic disease

The community of microorganisms that resides in the gut, known as the microbiome, has been shown to work in tandem with the genes of a host organism to regulate insulin secretion, a key variable in the onset of the metabolic disease diabetes.

17 Feb 2017

Single high-fat meal can change energy metabolism of the liver, study finds

The global proliferation of overweight and obese people and people with type 2 diabetes is often associated with the consumption of saturated fats.

16 Feb 2017

Changes in size of mitochondria in subset of brain cells could be key to maintaining blood sugar

Keeping blood sugar levels within a safe range is key to managing both type 1 and type 2 diabetes. In a new finding that could lead to fewer complications for diabetes patients, Yale School of Medicine researchers have found that changes in the size of mitochondria in a small subset of brain cells play a crucial role in safely maintaining blood sugar levels.

15 Feb 2017

TSRI scientists target obesity-linked protein to prevent weight gain in animal models

Scientists are working to understand the mechanisms that make weight loss so complicated. Exercise burns calories, of course, but scientists are also looking at how the body burns more energy to stay warm in cold temperatures.

15 Feb 2017

Weight gain over course of life can increase risk of developing oesophageal and stomach cancers

People who are overweight in their twenties and become obese later in life may be three times more likely to develop cancer of either the oesophagus (food pipe) or upper stomach, according to a study published in the British Journal of Cancer today (Wednesday).

15 Feb 2017

Scientists identify genetic signature of risk for type 2 diabetes

Why do some people get Type 2 diabetes, while others who live the same lifestyle never do? For decades, scientists have tried to solve this mystery - and have found more than 80 tiny DNA differences that seem to raise the risk of the disease in some people, or protect others from the damagingly high levels of blood sugar that are its hallmark.

14 Feb 2017

Joslin Diabetes Center participating in two clinical trials to test artificial pancreas systems

Joslin Diabetes Center will take part in two clinical trials this year to test artificial pancreas systems designed to automatically monitor and regulate blood glucose levels in people with type 1 diabetes, which would replace traditional methods of managing the disease such as testing blood glucose levels by finger stick or using continuous glucose monitoring systems with separate, non-integrated delivery of insulin by either injections or a pump.

14 Feb 2017

New infusion therapy may help avoid debilitating symptoms in Parkinson's disease patients

Constant infusion of a drug now used intermittently to "rescue" patients with Parkinson's from bouts of immobility may also help avoid these debilitating symptoms and smooth out their movement throughout the day, physician-scientists say.

14 Feb 2017

New report shows how to manage patients with obesity by prescribing optimal medications

While diet, exercise and behavior modification are essential components of obesity management, a successful long-term weight loss strategy should also include avoiding or minimizing medication-related weight gain, according to a new report from Weill Cornell Medicine.

14 Feb 2017

Study finds reduction in HbA1c levels with in-home use of hybrid closed-loop insulin delivery system

A pivotal registration trial to evaluate in-home use of the Medtronic MiniMed(r) 670G hybrid closed-loop insulin delivery system over 3 months showed a significant reduction in HbA1c levels for both adolescents and adults with type 1 diabetes.

13 Feb 2017

Insulin News and Research

Further Reading

Penn researchers identify genome-wide changes caused by high-fat diet

Researchers justify alternative theory about cause of type 1 diabetes

Researchers aim to develop sustained and controllable insulin release system for treatment of diabetes

Universal public coverage of essential medicines could save over $4 billion per year, study finds

Feast and famine diet may restore insulin production in diabetes

Physician-delivered step count prescription combined with use of pedometer can provide health benefits

Scientists establish ‘tipping point’ molecular link between blood sugar and Alzheimer's disease

BIDMC review focuses on neural circuitry of wakefulness and sleep

Epigenetic changes that affect formation of new muscle cells may be contributing factor to obesity

Anti-epilepsy medicine use during pregnancy does not harm overall health of children, study finds

Mice study provides clues to how genetic variations in gut microbes influence metabolic disease

Single high-fat meal can change energy metabolism of the liver, study finds

Changes in size of mitochondria in subset of brain cells could be key to maintaining blood sugar

TSRI scientists target obesity-linked protein to prevent weight gain in animal models

Weight gain over course of life can increase risk of developing oesophageal and stomach cancers

Scientists identify genetic signature of risk for type 2 diabetes

Joslin Diabetes Center participating in two clinical trials to test artificial pancreas systems

New infusion therapy may help avoid debilitating symptoms in Parkinson's disease patients

New report shows how to manage patients with obesity by prescribing optimal medications

Study finds reduction in HbA1c levels with in-home use of hybrid closed-loop insulin delivery system

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