Bioinformatics News and Research

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Bioinformatics is the application of information techniques for the storage, retrieval, and analysis of large quantities of biological data.

The effects of amino acid substitutions on the affinity of the SARS-CoV-2 spike RBD to the human receptor hACE2

Researchers performed a structural bioinformatics analysis to evaluate the binding energy of the SARS-CoV-2 Omicron variants of concern spike protein receptor-binding domain to human angiotensin-converting enzyme 2 receptor compared to other VOCs.

30 Aug 2022

Researchers find evidence of negative repercussions of immune history in SARS-CoV-2 infection

Researchers found proof of negative repercussions of immune history in SARS-CoV-2 infection.

30 Aug 2022

UB study reveals a mechanism of gene evolution generating mucin function

From the slime coating slugs to the saliva in our mouths, many slippery bodily fluids contain mucus. So how did this marvel of biology evolve?

26 Aug 2022

Penn-CHOP Kidney Innovation Center focuses on early detection, prevention, and treatment of kidney disease

In an effort to improve the lives of children and adults with kidney disease, Children's Hospital of Philadelphia and Penn Medicine are jointly launching the Penn-CHOP Kidney Innovation Center.

26 Aug 2022

Flipping the switch on retrons to combat antimicrobial resistance

In this interview, we speak to Dr. Jacob Bobonis about his new discovery regarding retrons and how they could be used to tackle antimicrobial resistance.

23 Aug 2022

Celebrating 10 Years of Global Research with Breast Cancer Now Tissue Bank

Breast Cancer Now Tissue Bank have just celebrated 10 years of groundbreaking breast cancer research. We spoke to Professor Louise Jones to find out more about this achievement!

22 Aug 2022

No one-size-fits-all AI program exists for all preventive treatments

A Rutgers analysis of dozens of artificial intelligence (AI) software programs used in precision, or personalized, medicine to prevent, diagnose and treat disease found that no program exists that can be used for all treatments.

18 Aug 2022

Researchers develop a novel method to screen publicly available raw WGS data of SARS-CoV-2

Researchers developed a novel method to screen publically available raw whole genome sequencing data of SARS-CoV-2 and identify mutations of interest more rapidly.

18 Aug 2022

New technique keeps the cells alive during RNA extraction

RNA sequencing allows scientists to study the expression of genes in a cell. Since messenger RNA (mRNA) is generated from a DNA gene, that information can be used to identify the original gene sequence and thus measure the activity of thousands of genes (i.e. the transcriptome) in these cells.

17 Aug 2022

KAUST bioscientists develop new method to study the bone marrow microenvironment in greater detail

Deep molecular analysis of the bone marrow microenvironment reveals that the cells regulating blood stem cell maintenance are more diverse than expected and have features likely to be conserved between species.

16 Aug 2022

Computational pipeline for the early identification of emerging SARS-CoV-2 variants

Researchers developed a computational pipeline for the early identification of emerging SARS-CoV-2 variants of interest by analyzing SARS-CoV-2 genome data and allocating risk scores on the basis of functional and epidemiological parameters.

16 Aug 2022

Older heart muscle cells accumulate new genetic mutations -; while losing the ability to repair them

Why does the risk of heart disease go up as we age? Known risk factors such as hypertension or high cholesterol don't explain all cases.

12 Aug 2022

Novel model reveals how genomic instability arises in histologically benign tissue

Understanding which cells give rise to which areas of cancer can improve our understanding of how a tumor has grown and developed, including how it has changed genetically, over time. This has been made possible using a new technique called spatial transcriptomics, which allows scientists to see what genetic changes take place without breaking up the tissue they're looking at.

11 Aug 2022

Gene expression in male and female brains become more similar with age, study says

When male and female fruit flies age, their brains become desexualized. Age-related changes take place in both sexes, but the male brain becomes feminized to a larger extent than the female brain becomes masculinized. This is the conclusion of a study performed by a research group at Linköping University. The findings are published in the journal Proceedings of the Royal Society of London B.

11 Aug 2022

Traditional Chinese medicine reduces severity of radiation-induced gastrointestinal mucositis in rats

For tens of thousands of Australians who receive radiotherapy as part of their cancer treatment, mucositis is a serious side effect that may cause inflammation, ulcers, diarrhea, nausea and vomiting, abdominal pain and bloating.

11 Aug 2022

Research reveals a gut-brain pathway that contributes to the development of Alzheimer’s disease

Research led by Drs. Yuhai Zhao and Walter J Lukiw at the LSU Health New Orleans Neuroscience Center and the Departments of Cell Biology and Anatomy, Neurology and Ophthalmology, reports for the first time a pathway that begins in the gut and ends with a potent pro-inflammatory toxin in brain cells contributing to the development of Alzheimer's disease (AD).

9 Aug 2022

Novel AI tools accurately predict the role of DNA’s regulatory elements

Newly developed artificial intelligence (AI) programs accurately predicted the role of DNA's regulatory elements and three-dimensional (3D) structure based solely on its raw sequence, according to two recent studies in Nature Genetics.

9 Aug 2022

Proof-of-concept model uses AI to combine multiple types of data to predict cancer outcomes

While it's long been understood that predicting outcomes in patients with cancer requires considering many factors, such as patient history, genes and disease pathology, clinicians struggle with integrating this information to make decisions about patient care.

8 Aug 2022

Discovery could prevent insulin resistance and have significant benefits for people with type 2 diabetes

In a potential game changer for patients with type 2 diabetes, a team of researchers at the Diabetes, Obesity, and Metabolism Institute (DOMI) at the Icahn School of Medicine at Mount Sinai has identified a therapeutic target for the preservation and regeneration of beta cells (β cells)-;cells in the pancreas that produce and distribute insulin.

4 Aug 2022

CHOP helps launch new computational platform to harmonize pediatric cancer data

Children's Hospital of Philadelphia has helped launch a new computational platform that will harmonize pediatric cancer data, allowing researchers, pharmaceutical companies, and advocacy groups to accelerate the pace of drug development for pediatric cancer.

4 Aug 2022

Bioinformatics News and Research

Further Reading

The effects of amino acid substitutions on the affinity of the SARS-CoV-2 spike RBD to the human receptor hACE2

Researchers find evidence of negative repercussions of immune history in SARS-CoV-2 infection

UB study reveals a mechanism of gene evolution generating mucin function

Penn-CHOP Kidney Innovation Center focuses on early detection, prevention, and treatment of kidney disease

Flipping the switch on retrons to combat antimicrobial resistance

Celebrating 10 Years of Global Research with Breast Cancer Now Tissue Bank

No one-size-fits-all AI program exists for all preventive treatments

Researchers develop a novel method to screen publicly available raw WGS data of SARS-CoV-2

New technique keeps the cells alive during RNA extraction

KAUST bioscientists develop new method to study the bone marrow microenvironment in greater detail

Computational pipeline for the early identification of emerging SARS-CoV-2 variants

Older heart muscle cells accumulate new genetic mutations -; while losing the ability to repair them

Novel model reveals how genomic instability arises in histologically benign tissue

Gene expression in male and female brains become more similar with age, study says

Traditional Chinese medicine reduces severity of radiation-induced gastrointestinal mucositis in rats

Research reveals a gut-brain pathway that contributes to the development of Alzheimer’s disease

Novel AI tools accurately predict the role of DNA’s regulatory elements

Proof-of-concept model uses AI to combine multiple types of data to predict cancer outcomes

Discovery could prevent insulin resistance and have significant benefits for people with type 2 diabetes

CHOP helps launch new computational platform to harmonize pediatric cancer data

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