Cancer Immunotherapy News and Research

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PICI awards $3 million to support early career cancer researchers

From improving immunotherapy response in childhood cancer patients, to better understanding how cancer's spread to the liver affects the body's immune system, to helping T cells stay energized to fight cancer, The Parker Institute for Cancer Immunotherapy (PICI)'s 2021 class of early career researchers award recipients are pursuing ideas that have the potential to change the face of oncology.

3 Mar 2021

Studies reveal the promise of newly engineered bispecific antibodies against tumor cells

Three studies - one each in Science, Science Translational Medicine, and Science Immunology - reveal the promise of newly engineered bispecific antibodies, including by demonstrating their power against previously inaccessible tumor cell targets for the first time, in two cases.

2 Mar 2021

Researchers develop mutant gene-targeted immunotherapy approach to fight cancers

A novel targeted immunotherapy approach developed by researchers at the Ludwig Center, the Lustgarten Laboratory, and Bloomberg~Kimmel Institute for Cancer Immunotherapy at the Johns Hopkins Kimmel Cancer Center employs new antibodies against genetically altered proteins to target cancers.

1 Mar 2021

Tumors use unique mechanism to switch on regulatory T cells for protection

Immunologists at St. Jude Children's Research Hospital have discovered that tumors use a unique mechanism to switch on regulatory T cells to protect themselves from attack by the immune system.

24 Feb 2021

AI-based 3D holographic microscopy found to be better at analyzing cancer immunotherapy

Live tracking and analyzing of the dynamics of chimeric antigen receptor (CAR) T-cells targeting cancer cells can open new avenues for the development of cancer immunotherapy.

24 Feb 2021

Study reveals how cancer cells escape death by lymphocytes

Immunotherapy continues to show exciting promise in more effectively combating several tumor types. Many current strategies focus on ensuring the efficient delivery of active cytotoxic cells directly to tumors.

24 Feb 2021

Novel hydrogel slowly releases RNA nanovaccines to shrink tumors

Messenger RNA (mRNA) vaccines to prevent COVID-19 have made headlines around the world recently, but scientists have also been working on mRNA vaccines to treat or prevent other diseases, including some forms of cancer.

17 Feb 2021

Study suggests a new way to personalize anti-CTLA-4 therapy for cancers

A Ludwig Cancer Research study has identified a novel mechanism by which a type of cancer immunotherapy known as CTLA-4 blockade can disable suppressive immune cells to aid the destruction of certain tumors.

15 Feb 2021

Research shows how chemicals in the tumor microenvironment enable cancer to evade attack

A paper published today in Nature shows how chemicals in the areas surrounding tumors--known as the tumor microenvironment--subvert the immune system and enable cancer to evade attack. These findings suggest that an existing drug could boost cancer immunotherapy.

15 Feb 2021

Scientists discover new immunotherapy target for malignant brain tumors

Scientists say they have discovered a potential new target for immunotherapy of malignant brain tumors, which so far have resisted the ground-breaking cancer treatment based on harnessing the body's immune system.

15 Feb 2021

New gut microbiome-based approach may have translational potential for cancer immunotherapy

Scientists from Nanjing University and the University of Macau have devised a new approach to extend the survival of transplanted probiotics in vivo, enhancing the efficacy of cancer chemo-/immunotherapies in mice.

11 Feb 2021

Inherited genetic variation may affect the response to cancer immunotherapy

For all their importance as a breakthrough treatment, the cancer immunotherapies known as checkpoint inhibitors still only benefit a small minority of patients, perhaps 15 percent across different types of cancer.

10 Feb 2021

Study reveals why Black men with prostate cancer have greater survival benefits from immunotherapy

Black men die more often of prostate cancer yet, paradoxically, have greater survival benefits from immunotherapy treatment.

10 Feb 2021

Biomarkers could help discriminate cancer therapy-associated kidney injury from other causes

A study by Mayo Clinic researchers published in Kidney International Reports finds that immune checkpoint inhibitors, may have negative consequences in some patients, including acute kidney inflammation, known as interstitial nephritis. Immune checkpoint inhibitors are used to treat cancer by stimulating the immune system to attack cancerous cells.

3 Feb 2021

Advances in tumor models could expand effectiveness of cancer immunotherapy

Scientists are hoping advances in cancer research could lead to a day when a patient's own immune system could be used to fight and destroy a wide range of tumors.

3 Feb 2021

Breast cancer‐on‐a‐chip to test the effectiveness of checkpoint inhibitor drugs

There are many mechanisms by which the body responds to foreign invaders. One of these involves the T-cells of the immune system, which have a number of different proteins on their surface called "checkpoint proteins."

2 Feb 2021

Study: Targeting glycoprotein could improve response to cancer immunotherapy

It was an unexpected discovery that started with an analysis of more than 1,000 genes. The question: why game-changing cancer immunotherapy treatments work for only a fraction of patients.

28 Jan 2021

Insight into cancer cells' own first aid could provide the basis for new immunotherapy

Insight into cancer cells' own first aid could help the development of a new type of treatment. Johanna Olweus and her team at the UiO (University of Oslo) and the OUS (Oslo University Hospital) are important contributors to this study, which has been published in Nature.

27 Jan 2021

IU researchers identify how breast cancer cells evade immune attacks

Researchers at the Indiana University Melvin and Bren Simon Comprehensive Cancer Center have identified how breast cancer cells hide from immune cells to stay alive. The discovery could lead to better immunotherapy treatment for patients.

27 Jan 2021

Study describes a safe potential therapeutic tool for liver regeneration

A new study led by researchers at the Center for Regenerative Medicine at Boston University School of Medicine (BUSM) and Boston Medical Center (BMC) now describes a safe new potential therapeutic tool for the recovery of liver function in chronic and acute liver diseases.

27 Jan 2021

Cancer Immunotherapy News and Research

PICI awards $3 million to support early career cancer researchers

Studies reveal the promise of newly engineered bispecific antibodies against tumor cells

Researchers develop mutant gene-targeted immunotherapy approach to fight cancers

Tumors use unique mechanism to switch on regulatory T cells for protection

AI-based 3D holographic microscopy found to be better at analyzing cancer immunotherapy

Study reveals how cancer cells escape death by lymphocytes

Novel hydrogel slowly releases RNA nanovaccines to shrink tumors

Study suggests a new way to personalize anti-CTLA-4 therapy for cancers

Research shows how chemicals in the tumor microenvironment enable cancer to evade attack

Scientists discover new immunotherapy target for malignant brain tumors

New gut microbiome-based approach may have translational potential for cancer immunotherapy

Inherited genetic variation may affect the response to cancer immunotherapy

Study reveals why Black men with prostate cancer have greater survival benefits from immunotherapy

Biomarkers could help discriminate cancer therapy-associated kidney injury from other causes

Advances in tumor models could expand effectiveness of cancer immunotherapy

Breast cancer‐on‐a‐chip to test the effectiveness of checkpoint inhibitor drugs

Study: Targeting glycoprotein could improve response to cancer immunotherapy

Insight into cancer cells' own first aid could provide the basis for new immunotherapy

IU researchers identify how breast cancer cells evade immune attacks

Study describes a safe potential therapeutic tool for liver regeneration

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